Search results for " regulation"
showing 7 items of 3187 documents
The endogenous retroviral insertion in the human complement C4 gene modulates the expression of homologous genes by antisense inhibition
2001
Intron 9 contains the complete endogenous retrovirus HERV-K(C4) as a 6.4-kb insertion in 60% of human C4 genes. The retroviral insertion is in reverse orientation to the C4 coding sequence. Therefore, expression of C4 could lead to the transcription of an antisense RNA, which might protect against exogenous retroviral infections. To test this hypothesis, open reading frames from the HERV sequence were subcloned in sense orientiation into a vector allowing expression of a beta-galactosidase fusion protein. Mouse L cells which had been stably transfected with either the human C4A or C4B gene both carrying the HERV insertion (LC4 cells), and L(Tk-) cells without the C4 gene were transiently tr…
The human autoantigen La/SS-B accelerates herpes simplex virus type 1 replication in transfected mouse 3T3 cells.
1998
SUMMARY Permanently transfected mouse cell lines which expressed different levels of the human autoantigen La/SS-B were infected with different strains of herpes simplex virus type 1, including the strains ANG, HSZP, 17syn+ and HFEM. During infection the localization of the human La protein was followed using an anti-La MoAb, which recognized only the human La protein but did not cross-react with either the endogenous mouse La protein or any viral encoded protein. After infection La protein was transported from the nucleus to the cytoplasm. The time course of translocation was dependent on the amount of human La protein expressed in the respective cell line. Moreover, acceleration of viral …
The role of the agreement as a tool for management of property relations in cases of cross border marriages and civil unions/partnerships registered …
2021
The essay examines the role of the agreement as a tool for managing property relationships in crossborder marriages and registered partnerships, in light of EU Regulations 1103 and 1104 of 2016, on the property regimes of international married or registered couples. The main prerogative of such acts is the recognition of the parties? freedom to choose the court and the applicable law. The law governing the matrimonial property regimes, or the property consequences of registered partnerships, has universal scope. This agreement in the form envisaged, which is backed by the need for legal certainty and predictability of the applicable rules, means that the spouses, in family problems which ha…
Deciding on the direction of career and life : personal goals, identity development, and well-being during the transition to adulthood
2017
Humans make efforts to manage their lives, and they do this by setting goals and making decisions. When they commit to their decisions, they construct their identity. This research aimed to study young people’s personal goal contents and appraisals, and how these constructs were related to identity and career identity development and subjective well-being. The theoretical basis of this research comprised the life-span model of motivation (Nurmi, 2004; Salmela-Aro, 2009), the conceptualisation of phase- adequate engagement (Dietrich, Parker, & Salmela-Aro, 2012), and the dual-cycle model of identity development (Luyckx, Goossens, Soenens, & Beyers, 2006; Luyckx et al., 2008). The data for th…
Modelling the influence of automaticity of behaviour on physical activity motivation, intention and actual behaviour
2014
In research and in practise social-cognitive models, such as the theory of planned behaviour (TPB), are used to predict physical activity behaviour. These models mainly focus on reflective cognitive processes. As a reflective process, intention is thought to be the most proximal predictor to behaviour. Nevertheless, research suggests that the relation between intention and actual behaviour, the so called intention-behaviour gap, is moderate. Many health-related actions in daily life are performed repetitively and with minimal forethought. In contrast to social-cognitive theories, dual-process theories suggest that behaviour is based on both reflective and automatic processes. Recent researc…
Etude en champ proche et champ lointain de surfaces métalliques : apport des microscopies à sonde locale à l'étude des étalons de masse
2005
Among the international system of units (SI) the kilogram is the only one which is still defined by a material artefact, the international prototype of the platinum iridium kilogram. The instability of mass standards is one of the major concerns of national metrology institutes and the subject of numerous studies. Interest in microscopic studies of surface quality of a mass has grown, as it is well known that surface roughness is a factor in determining the long-term stability of mass standards. This thesis is devoted to the study in near field and far field for determining the topography and roughness of metallic surfaces, in related with different institute, national and international met…
Latvijas nelegālā bezakcīzes alkohola aprite
2014
Elektroniskā versija nesatur pielikumus