Search results for " relations"

showing 10 items of 6439 documents

Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action

2015

Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…

trypanosomiasisStereochemistrysleeping sicknessCathepsin LDrug Evaluation PreclinicalChemistry Techniques SyntheticInhibition kineticsCysteine Proteinase InhibitorsBiochemistryCathepsin BInhibitory Concentration 50Structure-Activity RelationshipinhibitorsDrug DiscoveryHumansMoietyMolecular Targeted TherapyGeneral Pharmacology Toxicology and PharmaceuticsIC50Volume concentrationrhodesainPharmacologyChemistryOrganic ChemistryDual modeDipeptidesTrypanocidal AgentsCombinatorial chemistryMolecular Docking SimulationCysteine EndopeptidasesKineticsdipeptidyl enoatesTrypanosomiasis AfricanDocking (molecular)Molecular MedicineCysteine thiolateChemMedChem
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The role of tennis coaches in regulating their players' emotional states : an exploratory study

2014

During the past few decades, the ability to perceive, understand, and regulate emotions efficiently has received widespread attention in sport settings (Hanin, 2000; 2004; Robazza, Pellizzari, & Hanin, 2004). Moreover, this line of research has mainly focused on the intrapersonal aspect of emotions. The aim of the present study was to examine the role of tennis coaches in regulating their players’ emotional states. The present study explored (a) tennis players’ emotional states related to their best and worst performances, (b) coaches’ accuracy in assessing players’ emotional experiences within these performances, and (c) self- and interpersonal emotional regulation strategies of tennis coa…

tunneälytunteetpelaajatemotional regulationtennispsykososiaaliset tekijätemotional intelligencecoach-athlete relationshipemotionsvalmentajatpsychobiosocial state
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From Rationality to Emotionally Embedded Relations: Envy as a Signal of Power in Stakeholder Relations

2015

Although stakeholder salience theory has received a great deal of scholarly attention in the business ethics and management literature, the theory has been criticized for overemphasizing rationality in managerial perceptions. We argue that it is important to better understand what socially constructed emotions signal in business relations, and we posit the role of envy as a discursive resource used to signal and construct the asymmetrical power relations between small business owner–managers and their stakeholders. Our study is based on a qualitative study on discursive accounts elicited from 33 interviews with small business owner–managers in Finland. Our study makes two primary contributi…

tunteetkateusStakeholder relationsSmall business
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Gendered Work-life Ideologies among IT Professionals

2022

The study investigates the discourses IT professionals use to produce work–life relations. We focus on work–life ideologies and explore the agencies produced, as well as whether and how they are gendered. Our data were collected in interviews with 24 women and men working in the IT industry in Finland. Our results show, first, that work–life relations were constructed discursively through two different work–life ideologies, and second, that these ideologies produced different gendered agencies in reconciling work with life. In our study, work–life talk produced different positions for women and men, which were influenced by gendered norms and social expectations. We conclude that gendered a…

työelämän suhteetyhteensovittaminenwork-life relationsperhe-elämädiscoursessukupuolisukupuolittuminenwork-life ideologiesIT professionalstasa-arvosukupuoliroolittyöelämädoing genderFinlandtietotekniikka-alavapaa-aika
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A different glimpse into mobilities: On the interrelations between daily spatial mobility and social mobility

2017

We explore the link between daily spatial mobility and social mobility, taking changes in the contemporary labor market and family as examples. We propose a new theoretical approach to mobility that is defined as a productive force of social labor. Analyzing the relationship between daily spatial mobility and social mobility, we show that spatial mobility has become a strategy of compensation for the lack of social mobility. Explanations for the increase in daily spatial mobility are also provided. Lastly, we reveal how spatial mobility has the capacity to produce major social change, taking the family as an example. peerReviewed

työvoiman liikkuvuusCultural StudiesMobilitiesproductive force of social labormobilities05 social sciences0507 social and economic geographyta5142050801 communication & media studiesspatial mobilitySocial mobilitysosiaalinen liikkuvuusManagement Information Systemsliikkuvuus0508 media and communicationsSpatial mobilityPolitical Science and International RelationsSociologyEconomic geographysocial mobility050703 geographyInformation SystemsThe Information Society
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Working while studying: does it lead to greater attachment to the regional labour market?

2017

This chapter studies the link between working while studying and migration. Understanding this link is important because policy-makers are often calling for actions that would cut down the hours students spend on working to shorten the graduation time. The chapter’s analysis focuses on graduates from Finnish universities, polytechnics and vocational schools in 1991–2004. It uses rich register-based longitudinal microdata constructed by Statistics Finland, and find a negative relationship between working while studying and graduate migration. An increase in student employment can thus partly explain the decline in geographic mobility among Finnish graduates from higher education.

työvoiman liikkuvuusGeographic mobilityLabour economicsHigher educationbusiness.industrystudyinglabour mobilitytyömarkkinattyöRegional economicsNegative relationshiptyössäkäyntiMicrodata (HTML)Political scienceVocational educationlabour marketsopiskeluHuman geographytyövoimabusinessGraduation
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Posting and agency work in British construction and hospitality: the role of regulation in differentiating the experiences of migrants

2017

This article engages with IHRM debates on the transnational regulation of labour, exploring how migration policy and work fragmentation affect employment dynamics in multi-employer settings. It dra...

työvoiman liikkuvuusconstructionOrganizational Behavior and Human Resource ManagementLabour economicsStrategy and ManagementmigrationEuroopan unioniHospitalityfragmentationManagement of Technology and Innovation0502 economics and businessEconomicsagency workerspostingBusiness and International Managementbusiness.industry05 social sciences050209 industrial relationsta5142regulationhospitalityPublic relationsmuuttoliikeIndustrial relationsEUbusiness050203 business & managementThe International Journal of Human Resource Management
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Agency of labour in a flexible pan-European labour market : a qualitative study of migrant practices and trade union strategies in the Netherlands

2015

Regulatory frameworks on intra-EU mobility and flexible cross-border employment relations have stimulated competition on labour costs by recruiting migrants via cheaper labour market regimes. While it allows firms to remunerate migrants under different terms and conditions, blurring regulatory boundaries also generates opportunities for non-compliance, resulting in violations of migrant labour rights across Europe. Against this background, this thesis explores the agency of labour, more specifically of temporary migrant workers and unions, and the ways they cope with and respond to the competitive dynamics of the pan- European labour market. This study draws on 90 qualitative interviews wit…

työvoiman liikkuvuusvapaa liikkuvuusPaneurooppatyövoimapolitiikkaPaneurooppa-liiketyömarkkinasopimuksetDutch industrial relationstyöperäinen maahanmuuttohalpatyövoimaAlankomaattyömarkkinattoimijuustyömarkkinapolitiikkamaahanmuuttajatulkomainen työvoimatyömarkkina-asematrade unionsagencysiirtolaispolitiikkamigrant workerEurooppasiirtotyöläisetmigrant organisingposted worktyömarkkinajärjestöt
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The Promise and Deception of Participation in Welfare Services for Unemployed Young People

2018

This study examined the role of welfare services in the participative citizenship of young people under 30 years of age outside the labour market. Thematic content analysis of the government’s white papers regarding participation policies, as well as participatory action research projects in two Finnish towns, were used to identify factors that enable or hinder participation for this group of service users. The paradigm of participation was critically examined with reference to the theoretical framework of Max Horkheimer and Theodor Adorno’s “dialectic of Enlightenment”, which proposes the parallel existence of the promise and the deception of Enlightenment. The results indicated that user …

unemploymentdialectic of Enlightenmentmedia_common.quotation_subjectParticipatory action researchtyömarkkinatyoung peoplelcsh:Social SciencesosallistaminennuoretMedia TechnologyDemocratizationSociologymedia_commonosallistuminenGovernmentSocial workbusiness.industrywelfare serviceshyvinvointipalvelutPublic relationsDeceptiontyöttömyysparadigm of participationlcsh:HWorkfareWorkforceThematic analysisbusinessCritical Social Work
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Social Media as Platform for Stimulating Urban Changes

2016

Images have always been an important part of city planning – current images of place, images with planned improvements, maps and sketches. Some time ago all that was a private property of stakeholders like planner and client. But nowadays this confidentiality rather much has vanished – no copyrights or competition is noteworthy. Plans do not have their privacy anymore. They are exposed even before they got implemented. This article will display why city planners share the images of their ideas, of their dreams in public (mostly in blogs and social networks) – why it is important for them and what kind of feedback they are waiting for. This article is based on case study where 12 respondents…

urban plannerscomputer.software_genrevisual imaginationRather muchlcsh:Communication. Mass mediaCompetition (economics)city planningUrban planningConfidentialitySocial mediaindirect communicationlcsh:B1-5802computer.programming_languageMultimediacommunicationbusiness.industrylcsh:Philosophy (General)RealisationGeneral MedicinePublic relationsPlannerlcsh:P87-96imagesGeographyPrivate propertybusinesscomputeridea sharingCoactivity: Philosophy, Communication
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