Search results for " relationships"
showing 10 items of 317 documents
Synthesis of 8-aminomorphans with high KOR affinity
2021
2-Azabicyclo[3.3.1]nonanes (morphans) with a (3,4-dichlorophenyl)acetyl group at 2-position and a pyrrolidino moiety at 8-position were designed as conformationally restricted analogs of piperidine-based KOR agonists. The synthesis started with 4-oxopiperidine-2-carboxylic acid comprising 13 reaction steps. At first the ketone 10 was transformed into diester 7 bearing a propionate side chain. Dieckmann condensation of diester 7 to afford bicyclic enolester 14 and subsequent Krapcho deethoxycarbonylation represent the key steps of the synthesis. The enantiomeric pyrrolidines (1S,5R,8R)-5a and (1R,5S,8S)-5a were separated by chiral HPLC. The eutomer (1S,5R,8R)-5a showed high KOR affinity (K-i…
Il Disegno sostenibile ante litteram dell’architettura: la “Casa a ville sovrapposte” di Figini e Pollini a Milano
2022
Can drawing be taken as an exploratory key to study a symbolic building of Italian Rationalism? This paper will attempt to do so on the Casa a ville sovrapposte in Via dell'Annunciata in Milan, designed by Figini and Pollini in the 1930s. This famous building could constitute the reversal of the established paradigm according to which rationalist buildings are always detached from the urban context of which they are part. The use of drawing as a cognitive tool can help us decode the complex of different instances underlying the design of this emblematic building of the early 20th century in Italy, including the designers’ intention to integrate nature into living, almost in an ante litteram…
Le recrutement des jeunes docteurs dans le secteur privé
2007
This paper explores the relationship between the characteristics of the doctoral training and the recruitment of young PhDs in the private sector in France. We used information from a national representative survey of 1246 PhDs graduated in 2001 and interviewed in 2004. We focus on the recruitment and PhD returns among research-based jobs and non-research jobs in the private sector. Our econometrics results show that access and wages in the R&D jobs strongly depends on previous labour experience during the PhD (participation in a research contract, private funding for the PhD). In addition, we find that PhD students who expressed a preference for academia pay a wage penalty when they access…
Los documentales científicos como instrumentos de educación para la sostenibilidad
2010
El objeto de este trabajo se centra en analizar el papel que están jugando y pueden llegar a jugar los documentales científicos que se difunden ampliamente a través de la TV, venta en quioscos, etc., en la formación de una ciudadanía consciente de los problemas a los que se enfrenta hoy la humanidad y preparada para participar en la adopción de las medidas necesarias
New molecular data attest to the absence of cospeciation patterns between Placobdella costata (Fr. Müller, 1846) (Hirudinea) and freshwater turtles (…
2021
The only Palearctic representative of the leech genus Placobdella Blanchard, 1893 is P. costata, an ectoparasite of freshwater turtles. To date, no conclusive evidence about the possible presence of coevolutionary patterns between this leech and its turtle hosts is available due to the paucity of DNA sequence data available for P. costata; moreover, comparative host data is also mostly lacking, making any inferences more difficult. The discovery of new populations of the species in northern Italy and Sicily allowed us to generate novel mitochondrial DNA sequences and to compare the topology of the resulting phylogenetic trees with the phylogeny of the turtle hosts occurring in the study are…
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor
2013
The Eph–ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to inhibit EphA2 activation in prostate cancer cells. Herein, we report the synthesis and biological evaluation of a set of cholanic acid derivatives obtained by conjugation of its carboxyl group with a panel of naturally occurring amino acids with the aim to improve EphA2 receptor inhibition. Structure-activity relationships indicate that conjugation of cholanic acid with linear amino acids of small size leads to effective EphA2 antagonists whereas …
Homopolymerization of styrenic monomers and their copolymerization with ethylene using group 4 non‐metallocene catalysts
2020
Homopolymerization of styrenic monomers (St, p ‐Me‐St, p ‐t Bu‐St, p ‐t BuO‐St) and their copolymerization with ethylene, with the use of [( t Bu2O2NN′)ZrCl]2(μ‐O) (1 ) and ( t Bu2O2NN′)TiCl2 (2 ), where t Bu2O2NN′ = Me2N(CH2)2N(CH2‐2‐O−‐3,5‐t Bu2‐C6H2)2, is explored in the presence of MMAO and (i Bu)3Al/Ph3CB(C6F5)4. The ethylene/styrenic monomers copolymerization with 1 /MMAO produces exclusively copolymers with high activity and good comonomer incorporation whereas the other catalytic systems yield mixtures of copolymers and homopolymers. The use of p ‐alkyl styrene derivatives instead of styrene raises the catalytic activity, comonomer incorporation and molecular weights of the copolyme…
Concurrent and lagged effects of counterdispositional extraversion on vitality
2020
Abstract There are two contrasting perspectives on the effects of state extraversion. One states that people benefit from behaving extraverted, regardless of their level of trait extraversion. The second entails that behaving concordant to one’s trait is natural while deviations from the trait level— counterdispositional behaviors—are effortful to maintain, leading to mental fatigue. We test the possibility that both perspectives are correct, with beneficial effects of high state extraversion showing immediately, while the depleting counterdispositional effects are delayed. Experience sampling data from 67 employees (N = 1,664), shows that extraverted behaviors are associated with high leve…
Extraversion and performance approach goal orientation : An integrative approach to personality
2019
Abstract Research shows that extraversion is unrelated to performance approach goal orientation, both at the trait- and the state-level. However, since previous studies have either focused on the trait- or the state-level, such a conclusion may be premature. Building upon the idea that acting against one’s trait consumes self-control resources, we reason that within-person deviations from one’s level of trait extraversion might negatively relate to performance approach goal orientation. Using experience sampling data from 47 employees across 10 days (N = 307), we found that deviations from one’s trait extraversion levels are associated with lower levels of performance approach goal orientat…
What are the risk and protective factors for the well-being of adolescents with CF?
2021
La fibrosis quística (FQ) es una enfermedad crónica y hereditaria que compromete la vida de quienes la padecen, y se hace especialmente importante su impacto en la adolescencia. El afrontamiento que estos pacientes y sus familiares hagan de estas circunstancias que les han tocado vivir, puede mejorar o empeorar el curso y desenlace de la enfermedad. El objetivo es conocer los factores de riesgo y protectores que influyen en el bienestar de los adolescentes con FQ. Para ello se realizó una búsqueda bibliográfica de la literatura científica siguiendo la guía PRISMA en las siguientes bases de datos: Web of Science, ProQuest y Scopus. Se incluyeron artículos centrados en factores psicológicos d…