Search results for " reproducibility"

showing 10 items of 77 documents

Validity of the Novel Taiwan Lymphoscintigraphy Staging and Correlation of Cheng Lymphedema Grading for Unilateral Extremity Lymphedema

2018

Objective: The aim was to validate the new Taiwan Lymphoscintigraphy Staging, correlate it with Cheng Lymphedema Grading (CLG) and evaluate the treatment outcomes of unilateral extremity lymphedema. Background: No consensus has been reached for diagnosis and staging for patients with lymphedema among medical specialties. Methods: We included 285 patients with unilateral extremity lymphedema using lymphoscintigraphy. Lymphoscintigraphy was correlated to clinical symptoms and signs, and classified into normal lymphatic drainage, partial obstruction, and total obstruction. Inter- and intraobserver reliability of Taiwan Lymphoscintigraphy Staging, correlation between Taiwan Lymphoscintigraphy S…

Malemedicine.medical_specialtyValidation studyextremity lymphedemaTreatment outcomeTaiwanMEDLINEbreast cancer-related lymphedema030230 surgery03 medical and health scienceslymphoscintigraphy0302 clinical medicinehemic and lymphatic diseasesmedicineHumansLymphedemaGrading (tumors)breast cancer-related lymphedema; extremity lymphedema; lymphatic microsurgery; lymphedema diagnosis; Cheng Lymphedema Grading System; lymphoscintigraphy; Extremities; Female; Humans; Lymphedema; Lymphoscintigraphy; Male; Middle Aged; Reproducibility of Results; TaiwanExtramuralbusiness.industryReproducibility of ResultsExtremitiesMiddle Agedmedicine.diseaselymphatic microsurgeryhumanitiesbody regionsLymphedema030220 oncology & carcinogenesisCheng Lymphedema Grading SystemFemaleSurgeryRadiologylymphedema diagnosibusinessBreast Cancer Related Lymphedema
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Echocardiographic and lung ultrasound characteristics in ambulatory patients with dyspnea or prior heart failure.

2013

Purpose Lung ultrasound (LUS) represents a novel, noninvasive method in the assessment of extravascular lung water. We investigated the utility of LUS in ambulatory subjects with dyspnea or prior heart failure (HF). Methods We studied 81 ambulatory subjects with HF history or dyspnea who underwent transthoracic echocardiography (TTE) with LUS of 8 zones. Subjects with heart transplantation or pulmonary conditions known to interfere with LUS were excluded. A reviewer blinded to the clinical data performed echocardiographic measurements and quantified B-lines (reverberation artifacts arising from the pleural line). Results Of 81 subjects, 74 (91%) (median age 66 years, 39% men, median left ve…

Malemedicine.medical_specialtymedicine.medical_treatmentBlood PressureRisk AssessmentSensitivity and SpecificityNuclear Medicine and ImagingInternal medicinemedicine.arterymedicineAmbulatory CareHumansRadiology Nuclear Medicine and imagingSingle-Blind MethodLungDyspnea; Echocardiography; Heart failure; Lung ultrasound; Aged; Ambulatory Care; Blood Pressure; Dyspnea; Echocardiography; Extravascular Lung Water; Female; Heart Failure; Humans; Lung; Male; Middle Aged; Prognosis; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Single-Blind Method; Stroke Volume; Cardiology and Cardiovascular Medicine; Radiology Nuclear Medicine and ImagingAgedHeart transplantationHeart FailureLung ultrasoundEjection fractionbusiness.industryReproducibility of ResultsStroke VolumeStroke volumeMiddle Agedmedicine.diseasePrognosisBlood pressureDyspneaEchocardiographyHeart failureAmbulatoryPulmonary arteryExtravascular Lung WaterCardiologyVentricular pressureFemaleRadiologyCardiology and Cardiovascular MedicinebusinessEchocardiography (Mount Kisco, N.Y.)
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Mixed-model of ANOVA for measurement reproducibility in proteomics

2009

This work is a statistical analysis of reproducibility of a MALDI-TOF mass spectrometry experiment. Its aim is to evaluate measurement variability and compare peak intensities from two types of MALDI-TOF platforms. We compared and commented on the abilities of Principal Component Analysis and mixed-model analysis of variance to evaluate the biological variability and the technical variability of peak intensities in different patients. The properties and hypotheses of both methods are summarized and applied to spectra from plasma of patients with Hodgkin lymphoma. Principal Component Analysis checks rapidly the balance between the two variabilities; however, a mixed-model analysis of varianc…

Mixed modelProteomicsQuality Control030213 general clinical medicine[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]ProteomeBiophysicsAnalytical chemistryProteomicsBiochemistryMass Spectrometry03 medical and health sciences0302 clinical medicineStatisticsHumans030304 developmental biologyMathematicsMeasurement variabilityMeasurement reproducibility0303 health sciencesReproducibilityAnalysis of VariancePrincipal Component AnalysisComputersReproducibility of ResultsVariance (accounting)Blood ProteinsHodgkin DiseaseSpectrometry Mass Matrix-Assisted Laser Desorption-IonizationPrincipal component analysisAnalysis of varianceAdsorptionPeptidesSoftware
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A human post-mortem brain model for the standardization of multi-centre MRI studies

2015

Multi-centre MRI studies of the brain are essential for enrolling large and diverse patient cohorts, as required for the investigation of heterogeneous neurological and psychiatric diseases. However, the multi-site comparison of standard MRI data sets that are weighted with respect to tissue parameters such as the relaxation times (T1, T2) and proton density (PD) may be problematic, as signal intensities and image contrasts depend on site-specific details such as the sequences used, imaging parameters, and sensitivity profiles of the radiofrequency (RF) coils. Water or gel phantoms are frequently used for long-term and/or inter-site quality assessment. However, these phantoms hardly mimic t…

Models Anatomicmedicine.medical_specialtyNeurologyCognitive NeuroscienceModels NeurologicalMulti-centre MRI studies; Post-mortem brain; Quantitative MRI; Standardization; Aged; Artifacts; Brain; Female; Humans; Magnetic Resonance Imaging; Multicenter Studies as Topic; Phantoms Imaging; Reproducibility of Results; Models Anatomic; Models Neurological; Postmortem Changes; Cognitive Neuroscience; Neurology; Medicine (all)Cognitive neuroscienceImaging phantomPhantomsImagingWhite matterModelsPost-mortem brainmedicineHumansMulticenter Studies as TopicMagnetization transferMulti-centre MRI studiesAgedmedicine.diagnostic_testbusiness.industryPhantoms ImagingMedicine (all)AnatomicBrainReproducibility of ResultsMagnetic resonance imagingHuman brainQuantitative MRIMagnetic Resonance ImagingStandardizationmedicine.anatomical_structureNeurologyPostmortem ChangesNeurologicalFemaleBrainstemNuclear medicinebusinessArtifacts
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Highly selective detection of Epinephrine at oxidized Single-Wall Carbon Nanohorns modified Screen Printed Electrodes (SPEs)

2014

Oxidized Single-Wall Carbon Nanohorns (o-SWCNHs) were used, for the first time, to assemble chemically modified Screen Printed Electrodes (SPEs) selective towards the electrochemical detection of Epinephrine (Ep), in the presence of Serotonine-5-HT (S-5HT), Dopamine (DA), Nor-Epineprhine (Nor-Ep), Ascorbic Acid (AA), Acetaminophen (Ac) and Uric Acid (UA). The Ep neurotransmitter was detected by using Differential Pulse Voltammetry (DPV), in a wide linear range of concentration (2-2500 μM) with high sensitivity (55.77 A M(-1) cm(-2)), very good reproducibility (RSD% ranging from 2 to 10 for different SPEs), short response time for each measurement (only 2s) and low detection of limit (LOD=0.…

Neurotransmitters; Screen Printed Electrodes (SPEs); Selective detection; SWCNHs; Biosensing Techniques; Electrochemical Techniques; Electrodes; Epinephrine; Limit of Detection; Nanostructures; Oxidation-Reduction; Reproducibility of Results; Biophysics; Biomedical Engineering; Biotechnology; Electrochemistry; Medicine (all)NanostructureEpinephrineScreen Printed Electrodes (SPEs)ElectrodeBiophysicsAnalytical chemistryBiomedical EngineeringReproducibility of ResultBiosensing TechniquesElectrochemistryNanomaterialsSWCNHs; Screen Printed Electrodes (SPEs); Neurotransmitters; Selective detectionBiosensing TechniqueSelective detectionLimit of DetectionElectrochemistrySWCNHSettore CHIM/01 - Chimica AnaliticaNeurotransmitterElectrodesDetection limitSWCNHsReproducibilityElectrochemical TechniqueChemistryMedicine (all)Reproducibility of ResultsGeneral MedicineElectrochemical TechniquesNeurotransmittersAscorbic acidNanostructuresLinear rangeBiophysicElectrodeDifferential pulse voltammetryOxidation-ReductionNuclear chemistryBiotechnology
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Surrogate endpoints for overall survival in digestive oncology trials: which candidates? A questionnaires survey among clinicians and methodologists

2010

Abstract Background Overall survival (OS) is the gold standard for the demonstration of a clinical benefit in cancer trials. Replacement of OS by a surrogate endpoint allows to reduce trial duration. To date, few surrogate endpoints have been validated in digestive oncology. The aim of this study was to draw up an ordered list of potential surrogate endpoints for OS in digestive cancer trials, by way of a survey among clinicians and methodologists. Secondary objective was to obtain their opinion on surrogacy and quality of life (QoL). Methods In 2007 and 2008, self administered sequential questionnaires were sent to a panel of French clinicians and methodologists involved in the conduct of …

OncologyCancer ResearchTime FactorsDigestive System Neoplasms[ SDV.CAN ] Life Sciences [q-bio]/Cancer0302 clinical medicineQuality of lifeSurveys and QuestionnairesMedicine030212 general & internal medicineMESH: Treatment OutcomeResponse rate (survey)MESH : Evidence-Based MedicineClinical Trials as TopicEvidence-Based MedicineMESH: Endpoint DeterminationMESH: Research DesignMESH : QuestionnairesMESH : Research Designlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens3. Good healthMESH: Reproducibility of Resultsmedicine.anatomical_structureTreatment OutcomeOncologyResearch Design030220 oncology & carcinogenesisData Interpretation StatisticalMESH: Survival AnalysisMESH : Disease-Free SurvivalMESH : Endpoint DeterminationFranceMESH : Time FactorsResearch Articlemedicine.medical_specialtyMESH: Clinical Trials as TopicEndpoint DeterminationRectum[SDV.CAN]Life Sciences [q-bio]/CancerMESH : Treatment Outcomelcsh:RC254-282Disease-Free Survival03 medical and health sciences[SDV.CAN] Life Sciences [q-bio]/CancerInternal medicineGeneticsHumansMESH : Data Interpretation StatisticalMESH : FranceSurvival analysisMESH: Humansbusiness.industrySurrogate endpointMESH: Digestive System NeoplasmsMESH : Reproducibility of ResultsMESH: QuestionnairesMESH : HumansMESH: Time FactorsCancerReproducibility of ResultsMESH: Quality of LifeMESH : Quality of Lifemedicine.diseaseSurvival AnalysisMESH : Clinical Trials as TopicMESH: FranceLocalized diseaseEndpoint DeterminationMESH: Disease-Free SurvivalQuality of LifeMESH : Digestive System NeoplasmsMESH : Survival AnalysisbusinessMESH: Data Interpretation StatisticalMESH: Evidence-Based MedicineBMC Cancer
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Development and Validation of a New Prognostic System for Patients with Hepatocellular Carcinoma

2016

Background Prognostic assessment in patients with hepatocellular carcinoma (HCC) remains controversial. Using the Italian Liver Cancer (ITA.LI.CA) database as a training set, we sought to develop and validate a new prognostic system for patients with HCC. Methods and Findings Prospective collected databases from Italy (training cohort, n = 3,628; internal validation cohort, n = 1,555) and Taiwan (external validation cohort, n = 2,651) were used to develop the ITA.LI.CA prognostic system. We first defined ITA.LI.CA stages (0, A, B1, B2, B3, C) using only tumor characteristics (largest tumor diameter, number of nodules, intra- and extrahepatic macroscopic vascular invasion, extrahepatic metas…

OncologyMaleTime FactorsDatabases FactualCancer Treatmentlcsh:MedicinePredictive Value of TestPediatricsBiochemistryGeographical locationsNeoplasms Multiple PrimaryDecision Support Technique0302 clinical medicineInterquartile rangeRetrospective StudieMultiple PrimaryRisk FactorsNeoplasmsMedicine and Health SciencesEthnicitiesPublic and Occupational HealthLiver DiseasesLiver NeoplasmsChild HealthGeneral MedicineMiddle AgedPrognosisItalian PeopleTumor BurdenQuartileOncologyCirrhosisItalyLiver Neoplasm030220 oncology & carcinogenesisPredictive value of testsCohortPerspectiveHong Kong030211 gastroenterology & hepatologyFemaleSurvival Analysialpha-FetoproteinsHumanBiotechnologymedicine.medical_specialtyCarcinoma HepatocellularAsiaTime FactorSettore MED/12 - GASTROENTEROLOGIAAged; Carcinoma Hepatocellular; Databases Factual; Decision Support Techniques; Female; Humans; Italy; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Neoplasms Multiple Primary; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; Survival Analysis; Taiwan; Time Factors; Tumor Burden; alpha-Fetoproteins; Biotechnology; Biochemistry; Molecular Biology; Cell BiologyTaiwanReproducibility of ResultGastroenterology and HepatologyCarcinomasRisk AssessmentDecision Support Techniques03 medical and health sciencesDatabasesDiagnostic MedicinePredictive Value of TestsInternal medicineGastrointestinal TumorsmedicineHumansNeoplasm Invasivenessalpha-FetoproteinMolecular BiologySurvival analysisFactualAgedNeoplasm StagingRetrospective StudiesNeoplasm InvasivenePerformance statusbusiness.industryRisk Factorlcsh:RCarcinomaCancers and NeoplasmsReproducibility of ResultsRetrospective cohort studyHepatocellularHepatocellular CarcinomaCell BiologySurvival AnalysisBCLC StageSurgeryPeople and PlacesPopulation Groupingsbusiness
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Assessment of the 4-factor score: Retrospective analysis of 586 CLL patients receiving ibrutinib. A campus CLL study

2021

Not Available

OncologyMalechronic B cell leukemiachronic lymphocytic leukemia; ibrutinib; 4-factor score; prognosis.Datasets as TopicSeverity of Illness Indexchemistry.chemical_compoundPiperidinesRetrospective analysisMulticenter Studies as TopicChronicLeukemiaHematologyMiddle AgedPrognosisLymphocyticProgression-Free SurvivalIbrutinibFemalemedicine.medical_specialtyreal-word studyFactor scoreAntineoplastic AgentsAdenine; Aged; Antineoplastic Agents; Datasets as Topic; Female; Follow-Up Studies; Humans; Leukemia Lymphocytic Chronic B-Cell; Male; Middle Aged; Multicenter Studies as Topic; Piperidines; Prognosis; Progression-Free Survival; Proportional Hazards Models; Protein Kinase Inhibitors; Reproducibility of Results; Retrospective Studies; Risk Assessment; Severity of Illness Index; Survival AnalysisRisk AssessmentNOibrutinibInternal medicineSeverity of illnessmedicineHumansProgression-free survivalProtein Kinase InhibitorsSurvival analysisAgedProportional Hazards ModelsRetrospective Studiesbusiness.industryProportional hazards modelAdenineB-CellReproducibility of ResultsRetrospective cohort studyAdenine; Aged; Antineoplastic Agents; Datasets as Topic; Female; Follow-Up Studies; Humans; Leukemia Lymphocytic Chronic B-Cell; Male; Middle Aged; Multicenter Studies as Topic; Piperidines; Prognosis; Progression-Free Survival; Proportional Hazards Models; Protein Kinase Inhibitors; Reproducibility of Results; Retrospective Studies; Risk Assessment; Survival Analysis; Severity of Illness IndexLeukemia Lymphocytic Chronic B-CellSurvival AnalysisSettore MED/15 - MALATTIE DEL SANGUEchemistrybusinesschronic lymphocytic leukaemiaFollow-Up Studies
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Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Ora…

2021

Background: The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results: Oral lichen planus pati…

OralSleep Wake DisordersCancer Researchmedicine.medical_specialtyanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbance; Anxiety; Case-Control Studies; Depression; Female; Humans; Pathology Oral; Reproducibility of Results; Sleep; Surveys and Questionnaires; Lichen Planus Oral; Sleep Wake DisordersinsomniaReproducibility of Resultoral lichen planuPathology and Forensic MedicineSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHEPittsburgh Sleep Quality Indexoral lichen planusstomatognathic systemSurveys and QuestionnairesInsomniamedicineNumeric Rating ScalePathologySurveys and QuestionnaireHumansanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbancemood disturbanceSleep disorderbusiness.industryDepressionEpworth Sleepiness ScaleLichen PlanusReproducibility of ResultsRating scales for depressionmedicine.diseaseanxietysleep disturbancehumanitiesstomatognathic diseasesOtorhinolaryngologyCase-Control StudiesPathology OralPhysical therapyPeriodonticsAnxietyOral lichen planusFemaleOral Surgerymedicine.symptomCase-Control StudiebusinessSleepHumanLichen Planus Oral
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Surgical time for graft preparation using different suture techniques

2016

Background: The purpose of the present study was to compare the operative time for graft prepa- ration using different techniques for graft sutur- ing. Material and methods: Flexor profundus tendons were harvested from fresh pig hind-leg trotters. Three different suture techniques were investigat- ed: the Krackow stitch (K), the Whipstitch (W), and the Modified Finger-Trap suture (MFT). Ten- dons were sutured starting at 10 mm from the dis- tal free end of the tendon. The suture configura- tions of the Krackow stitch and Whipstitch were completed with five suture throws. According to the MFT technique, the suture was wrapped five times around the tendon over a distance of 30 mm. The time re…

OrthodonticsSuturing techniques030222 orthopedicsmedicine.medical_specialtybusiness.industrymodified finger-trap suture time consuming krakow stitch whipstitchInterobserver reproducibilitySurgeryTendon03 medical and health sciencesSurgical time0302 clinical medicinemedicine.anatomical_structureSuture (anatomy)Settore MED/33 - Malattie Apparato LocomotoreMedicineOperative timeOriginal ArticleOrthopedics and Sports Medicine030212 general & internal medicinebusinessMuscle Ligaments and Tendons Journal
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