Search results for " rese"
showing 10 items of 14841 documents
Sex differences in correlates of intermediate phenotypes and prevalent cardiovascular disease in the general population
2015
Background: There are marked sex differences in cardiovascular disease (CVD) manifestation. It is largely unknown how the distribution of CVD risk factors or intermediate phenotypes explain sex-specific differences. Methods and Results: In 5000 individuals of the population-based Gutenberg Health Study, mean age 55 ± 11 years, 51% males, we examined sex-specific associations of classical CVD risk factors with intima-media thickness, ankle-brachial index, flow-mediated dilation, peripheral arterial tonometry, echocardiographic, and electrocardiographic variables. Intermediate cardiovascular phenotypes were related to prevalent CVD [coronary artery disease, heart failure, stroke, myocardial i…
A 10-Week Block of Combined High-Intensity Endurance and Strength Training Produced Similar Changes in Dynamic Strength, Body Composition, and Serum …
2020
Purpose: To examine the potential sex differences in adaptations to combined endurance and strength training in recreationally endurance trained (eumenorrheic) women (n = 9) and men (n = 10). Methods: Isometric (ISOMmax) and dynamic bilateral leg press (1RM), countermovement jump (CMJ), running performance (3,000 m time trial), lean mass and body fat % (LEAN and FAT% determined by dual X-ray absorptiometry) as well as serum testosterone and cortisol (TES and COR, respectively, measured using hormone-specific immunoassay kits) were examined before a control period and pre, mid, and post a supervised 10-week combined high-intensity interval endurance training (4 × 4 min intervals and 3 × 3 × …
Sex Differences in the Physiological Network of Healthy Young Subjects
2021
Within human physiology, systemic interactions couple physiological variables to maintain homeostasis. These interactions change according to health status and are modified by factors such as age and sex. For several physiological processes, sex-based distinctions in normal physiology are present and defined in isolation. However, new methodologies are indispensable to analyze system-wide properties and interactions with the objective of exploring differences between sexes. Here we propose a new method to construct complex inferential networks from a normalization using the clinical criteria for health of physiological variables, and the correlations between anthropometric and blood tests b…
Huhut, unet, sodomiitit, moraalinvartijat, elämäkerrat, puhuttelusanat ja ammattinimikkeet
2022
Kirja Huhut, unet, sodomiitit, moraalinvartijat, elämäkerrat,puhuttelusanat ja ammattinimikkeet koostuu teoreettisista artikkeleista ja tutkielmista, joiden käsittelemät aikakaudet ulottuvat keskiajalta aina itsenäisyyden murrosvaiheisiin. Teemaa lähestytään yksilön ja yhteiskunnan välisten suhteiden ilmentymänä. Artlkkelit edustavat kunkin kirjoittajan tutkimussuuntausta. Näin ollen kyseessä on teos, jossa esitetään myös uusimman historiantutkimuksen tuloksia. Kirjoittajat ovat historiantutkijoita ja Jyväskylän maakunta-arkiston henkilökuntaa.
TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human
2021
TALPID3/KIAA0586 is an evolutionary conserved protein, which plays an essential role in protein trafficking. Its role during gastrointestinal (GI) and enteric nervous system (ENS) development has not been studied previously. Here, we analyzed chicken, mouse and human embryonic GI tissues with TALPID3 mutations. The GI tract of TALPID3 chicken embryos was shortened and malformed. Histologically, the gut smooth muscle was mispatterned and enteric neural crest cells were scattered throughout the gut wall. Analysis of the Hedgehog pathway and gut extracellular matrix provided causative reasons for these defects. Interestingly, chicken intra-species grafting experiments and a conditional knockou…
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
2012
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…
Space-by-Time Modular Decomposition Effectively Describes Whole-Body Muscle Activity During Upright Reaching in Various Directions
2017
The modular control hypothesis suggests that motor commands are built from precoded modules whose specific combined recruitment can allow the performance of virtually any motor task. Despite considerable experimental support, this hypothesis remains tentative as classical findings of reduced dimensionality in muscle activity may also result from other constraints (biomechanical couplings, data averaging or low dimensionality of motor tasks). Here we assessed the effectiveness of modularity in describing muscle activity in a comprehensive experiment comprising 72 distinct point-to-point whole-body movements during which the activity of 30 muscles was recorded. To identify invariant modules o…
Analysis and evaluation of the inclusive model in infant and primary centre support systems
2016
En esta investigación se analiza el funcionamiento y la organización de los sistemas de apoyo utilizados en centros de Educación Infantil y Primaria de la Comunidad Valenciana. Planteamos hasta qué punto los sistemas de apoyo en estos centros contribuyen a mejorar la organización de un sistema inclusivo que resulte accesible para todos. En el estudio de casos han participado 24 profesionales pertenecientes a cuatro centros que tienen diferentes modalidades de escolarización. Para la recogida de información, se han manejado instrumentos cualitativos como son la entrevista, la observación y el análisis documental. Según los datos obtenidos, los sistemas de apoyo no se ajustan de forma integra…
La influencia del estado del partido en la posesión del balón en el fútbol femenino de alto rendimiento
2020
[Abstract] The objective of this study was to examine the effect of the situational match status variable on the ball possession of the teams that participated in the 2015 FIFA Women’s World Cup. The 52 games played during the championship have been collected, and 3,740 ball possessions made by the teams were analyzed. The teams have been divided into successful and unsuccessful. Three types of analysis have been carried out: a univariate analysis for both groups with the categorical and continuous variables selected; a bivariate analysis, using chi-square tests and the exact Fischer test; and finally, a multivariable technique such as the decision trees was incorporated. The available resu…
Pasakas izmantošana 4-5 gadus vecuma bērnu skaitļu apguves veicināšanai
2017
Kvalifikācijas darbs izstrādāts par tēmu „Pasakas izmantošana 4-5 gadus vecuma bērnu skaitļu apguves veicināšanai”. Pētījums izstrādāts ar mērķi teorētiski pētīt un empīriski pamatot pasaku izmantošanas iespējas skaitļu apguves veicināšanai 4-5 gadus veciem bērniem un apkopot ieteikumus. Pētījums sastāv no divām daļām – teorētiskās un empīriskās. Teorētiskajā daļā, balstoties uz tādu autoru darbiem kā E. Krastiņa, R. Andersone, J. Mencis (2011), I. Lika (2003), G. Svence (1999), R. Ukstiņa (2003), L. Vengers (Венгер, 1986, 1988), N. Boilšunbova (Большунова, 2000), Ž. Piažē (Пиаже, 1997), A. Smoļenceva (Смоленцева, 2006), L. Fesjukova (Фесюкова, 2010), u.c. analizēti tādi jautājumi kā 4-5 ga…