Search results for " rese"
showing 10 items of 14841 documents
The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment
2019
Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This…
Comparing the Effect of Product-Based Metrics on the Translation Process
2021
Characteristics of the translation product are often used in translation process research as predictors for cognitive load, and by extension translation difficulty. In the last decade, user-activity information such as eye-tracking data has been increasingly employed as an experimental tool for that purpose. In this paper, we take a similar approach. We look for significant effects that different predictors may have on three different eye-tracking measures: First Fixation Duration (duration of first fixation on a token), Eye-Key Span (duration between first fixation on a token and the first keystroke contributing to its translation), and Total Reading Time on source tokens (sum of fixations…
Dealing with viewers’ complaints: Role, visibility and transparency of PSB Ombudsmen in ten European countries
2017
The article shows the results of a comparative analysis of the complaints management mechanisms offered by ten European Public Service Broadcasting (PSB) systems on their corporate websites. Using a qualitative methodology, it maps the procedures and evaluates the visibility, transparency and dissemination of results. The findings show, firstly, great diversity in terms of responsible election and management, despite the converging media governance. Also noteworthy is the margin of substantial improvement in the transparency and dissemination possibilities, specially relating to the interaction offered by the digital environment. Among the ten public corporations analysed, the BBC is the be…
A two-phase insertion technique of unexpected customers for a dynamic dial-a-ride problem
2006
Abstract This work deals with a dynamic dial-a-ride problem with time window constraints. In particular, new unplanned requests for service may arise at a vehicle stop and the driver must decide in real-time whether to accept or reject them. For this problem, we have developed a two-phase insertion algorithm based on route perturbations: the first phase, which is run off-line when the vehicle moves between two successive stops, aims at creating a feasible neighborhood of the current route; while the second phase, which is run in real-time every time a new request occurs, inserts, when possible, the delivery stop of the new customer in the current route.
Minimizing fleet operating costs for a container transportation company
2006
Abstract This paper focuses on a fleet management problem that arises in container trucking industry. From the container transportation company perspective, the present and future operating costs to minimize can be divided in three components: the routing costs, the resource (i.e., driver and truck) assignment costs and the container repositioning costs (i.e., the costs of restoring a given container fleet distribution over the serviced territory, as requested by the shippers that own the containers). This real-world problem has been modeled as an integer programming problem. The proposed solution approach is based on the decomposition of this problem in three simpler sub-problems associate…
The fate of patients with locally advanced bladder cancer treated conservatively with neoadjuvant chemotherapy, extensive transurethral resection and…
1998
Purpose: The authors assessed the results of bladder preservation for infiltrating bladder cancer. The potential for neoadjuvant chemotherapy followed by extensive transurethral resection and radiation therapy was evaluated in 40 patients with T2-T4a G2-G3 bladder carcinoma. Materials and Methods: From 1983 to 1995, 40 patients with bladder cancer underwent bladder-sparing treatment, consisting of neoadjuvant chemotherapy, extensive transurethral resection, and radiation therapy. Most patients had T3G3 cancer. A deep transurethral resection biopsy was performed before and after chemotherapy, and an extensive transurethral resection was repeated at the end of radiation therapy. Thirty patien…
Clinical Potential of Circulating Cell-Free DNA (cfDNA) for Longitudinally Monitoring Clinical Outcomes in the First-Line Setting of Non-Small-Cell L…
2022
Background: Despite the increasing implementation of targeted and immunotherapy-based treatments, the prognosis of patients with advanced NSCLC remains dismal. We prospectively evaluated longitudinal plasma cfDNA kinetics as an early marker of therapeutic efficacy in patients with advanced NSCLC undergoing standard first-line treatments. Methods: From February 2020 to May 2022, treatment-naïve patients with advanced NSCLC were consecutively enrolled at the Medical Oncology Unit of the Paolo Giaccone University Hospital, Palermo (Italy). We quantified cfDNA in terms of ng/μL using a QubitTM dsDNA HS Assay Kit. The agreement between the cfDNA and radiologic response was evaluated from…
Divergent Patterns and Trends in Breast Cancer Incidence, Mortality and Survival Among Older Women in Germany and the United States
2020
Background: Breast cancer treatment has changed tremendously over the last decades. In addition, the use of mammography screening for early detection has increased strongly. To evaluate the impact of these developments, long-term trends in incidence, mortality, stage distribution and survival were investigated for Germany and the United States (US). Methods: Using population-based cancer registry data, long-term incidence and mortality trends (1975&ndash
Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments
2021
Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting quality of life and overall survival in cancer patients. Pre-clinical studies have shown that blocking activin receptor type 2 (ACVR2) or its ligands and their downstream signaling can preserve muscle mass in rodents bearing experimental cancers, as well as in chemotherapy-treated animals. In tumor-bearing mice, the prevention of skeletal and respiratory muscle wasting was also associated with improved survival. However, the definitive proof tha…
Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs
2014
Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the size for potential applications in nanomedicine, in either disease diagnosis or therapy. This is of particular interest for research in cancer, also because the vast majority of existing data on EV are coming from pre-clinical and clinical oncology. We know that the microenvironmental features of cancer may favor cell-to-cell paracrine communication through EV, but EV have been purified, characterized, and quantified from plasma of tu…