Search results for " rese"

PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.

2011

We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…

Visual Contrast Modulates Operant Learning Responses in Larval Zebrafish.

2018

The larval zebrafish is a promising vertebrate model organism to study neural mechanisms underlying learning and memory due to its small brain and rich behavioral repertoire. Here, we report on a high-throughput operant conditioning system for zebrafish larvae, which can simultaneously train 12 fish to associate a visual conditioned pattern with electroshocks. We find that the learning responses can be enhanced by the visual contrast, not the spatial features of the conditioned patterns, highlighted by several behavioral metrics. By further characterizing the learning curves as well as memory extinction, we demonstrate that the percentage of learners and the memory length increase as the co…

Toimijuus korkeakoulutettujen suomen oppijoiden visuaalisissa narratiiveissa

2018

This socioculturally informed study explores how highly educated Finnish language learners represent their agency in visual narratives. Learners (n=59) were asked to draw two pictures of themselves as Finnish language users and provide verbal interpretations of the drawings. The aim of using visual narratives is to reach aspects such as feelings and beliefs which might be difficult to express verbally. The data were analyzed first by using visual grammar set out by Kress and van Leeuwen (2006) and secondly by content analysis. The findings suggest that learners saw Finnish language as a tool for oral communication. However, difficulties with speaking and listening appeared to restrict learn…

I look but do I see? : the application of visual design grammar in an introductory image analysis discussion course

2004

Explicit behavioral detection of visual changes develops without their implicit neurophysiological detectability

2011

Change blindness is a failure of reporting major changes across consecutive images if separated, e.g., by a brief blank interval. Successful change detection across interrupts requires focal attention to the changes. However, findings of implicit detection of visual changes during change blindness have raised the question of whether the implicit mode is necessary for development of the explicit mode. To this end, we recorded the visual mismatch negativity (vMMN) of the event-related potentials (ERPs) of the brain, an index of implicit pre-attentive visual change detection, in adult humans performing an oddball-variant of change blindness flicker task. Images of 500 ms in duration were prese…

Positive Effects of Videogame Use on Visuospatial Competencies: The Impact of Visualization Style in Preadolescents and Adolescents

2019

Use of videogames (VGs) is almost ubiquitous in preadolescents' and adolescents' everyday life. One of the most intriguing research topics about positive effects of VG use is about the domain of visuospatial competencies. Previous research show that training with videogames enables children and adolescents to improve their scores in visuospatial tests (such as mental rotation of shapes and cubes), and that such training could overcome gender differences in these domains. Our study aimed at (1) verifying the positive effects of videogame use in the visuospatial domain both for male and female adolescents and preadolescents and (2) verifying whether the visualization style (2D or isometric 3D…

Procedures for study of teaching practices. Literature Review

2012

Interest in studying teaching practices has increased, because of the need to evaluate teachers and dissatisfaction with the usual ways of doing it. Recent approaches with Value-Added Models, based on students’ results on achievement tests do not seem satisfactory. The article is based on a review of literature and classifies the approaches to practices in three groups: instruments based on information given by teachers; observation protocols; and approaches based on the analysis of products of the practices. Specific tools are described and advantages and disadvantages of the three approaches are discussed. El interés por las prácticas docentes ha aumentado, en parte por la necesidad de ev…

Vocational teachers' professional agency in the stream of change

2013

“Voz del alumnado”: hacer de los estudiantes participantes activos y responsables en los procesos formativos activados en la escuela y en la universi…

2017

"Voce degli studenti" è un movimento pedagogico nato negli anni novanta in alcuni paesi di lingua inglese (Stati Uniti, Canada, Inghilterra e Australia). Supporta la partecipazione attiva e responsabile degli studenti ai processi di formazione attivati nella scuola e nell'università. Per includere le voci degli studenti in questi processi, gli adulti (insegnanti e amministratori) devono riconoscere i loro diritti di essere ascoltati e rispettati come persone con interessi, bisogni di apprendimento e idee che possono risolvere i problemi della didattica scolastica/universitaria, della ricerca educativa e delle politiche culturali in cui si devono prendere decisioni che li riguardano. In ques…

Does using a visual-representation tool foster students’ ability to identify forces and construct free-body diagrams?

2013

Earlier research has shown that after physics instruction, many students have difficulties with the force concept, and with constructing free-body diagrams (FBDs). It has been suggested that treating forces as interactions could help students to identify forces as well as to construct the correct FBDs. While there is evidence that identifying interactions helps students in quantitative problem solving, there is no previous research investigating the effect of a visual-representation tool—an interaction diagram (ID)—on students’ ability to identify forces, and to construct the correct FBDs.We present an empirical study conducted in 11 Finnish high schools on students (n ¼ 335, aged 16) takin…