Search results for " resolution"
showing 10 items of 1159 documents
Candida antarctica Lipase A-Based Enantiorecognition of a Highly Strained 4-Dibenzocyclooctynol (DIBO) Used for PET Imaging
2020
The enantiomers of aromatic 4-dibenzocyclooctynol (DIBO), used for radiolabeling and subsequent conjugation of biomolecules to form radioligands for positron emission tomography (PET), were separated by kinetic resolution using lipase A from Candida antarctica (CAL-A). In optimized conditions, (R)-DIBO [(R)-1, ee 95%] and its acetylated (S)-ester [(S)-2, ee 96%] were isolated. In silico docking results explained the ability of CAL-A to differentiate the enantiomers of DIBO and to accommodate various acyl donors. Anhydrous MgCl2 was used for binding water from the reaction medium and, thus, for obtaining higher conversion by preventing hydrolysis of the product (S)-2 into the starting materi…
. New ground-based lidar enables volcanic CO2 flux measurements
2015
AbstractThere have been substantial advances in the ability to monitor the activity of hazardous volcanoes in recent decades. However, obtaining early warning of eruptions remains challenging, because the patterns and consequences of volcanic unrests are both complex and nonlinear. Measuring volcanic gases has long been a key aspect of volcano monitoring since these mobile fluids should reach the surface long before the magma. There has been considerable progress in methods for remote and in-situ gas sensing, but measuring the flux of volcanic CO2—the most reliable gas precursor to an eruption—has remained a challenge. Here we report on the first direct quantitative measurements of the volc…
Exposure assessment of mycotoxins in food and biological samples through high resolution mass spectrometry-based strategies
2022
Las micotoxinas son metabolitos secundarios tóxicos producidos por varios géneros de hongos y que se encuentran frecuentemente en productos alimenticios. La ingestión de micotoxinas puede provocar la aparición de un amplio abanico de efectos perjudiciales para la salud. Con el objetivo de reducir el impacto sanitario debido a la ingesta de productos contaminados por micotoxinas, la Comisión Europea estableció la Regulación No 1881/2006, donde se fijan límites máximos para ciertas micotoxinas en varias tipologías de productos alimenticios. Como herramienta complementaria, el Panel de Contaminantes en la Cadena Alimentaria (CONTAM Panel) han propuesto valores de ingesta diaria tolerable, que …
Conflicts and Negotiations in the Intergenerational Succession of Family Firms: A Literature Review.
2019
This chapter intends to stimulate a serious debate on the topic of conflict in family businesses and the theory of negotiation as a tool to resolve these conflicts. The methodology is based on the survey of the main literature on these topics. Despite the literature on conflict management is highly developed as well as the literature in family business, scholars and researchers have not yet deepened several areas of conflict management in family businesses, so the two fields of literature are yet not well integrated, showing a potential for future research avenues. We then propose a research agenda identifying the issues and research gaps that should be explored by researchers to reach a de…
Evaluation of Anal Sphincter with High Resolution Anorectal Manometry and 3D Reconstruction in Patients with Anorectal Malformation
2023
Background: Patients with anorectal malformation (ARM) need long-term follow-up, in order to evaluate fecal continence; the main predictors of longer-term success are the type of ARM, associated anomalies and sacral integrity. Three-Dimensional High Resolution Anorectal Manometry (3D-HRAM) gives detailed information on pressure on the anal complex profile. Our objective was to analyze anal sphincter activity in ARM patients with 3D-HRAM establishing the correlation between manometric and clinical data. Methods: Forty ARM patients were submitted to 3D-HRAM: manometric, anatomical and clinical scores were correlated with each other and with the bowel management response (BM). Results: A posit…
Comparison of the accumulation of fibre breaks occurring in a unidirectional carbon/epoxy composite identified in a multi-scale micro-mechanical mode…
2010
National audience; A model to predict fibre break accumulation that takes into account all physical phenomena at the origin of the fibre break (i.e. the random nature, stress transfer due to breaks, fibre debonding and viscosity of the matrix) shows clearly that the failure of a unidirectional composite structure results in the formation of random fibre breaks which at higher loads coalesce into clusters of broken fibres. The object of the study is to experimentally confirm this scenario. Many techniques exist to detect the failure of carbon fibre composites, however none of them offer a resolution that allows this goal to be achieved in a non-destructive manner and in three dimensions. Hig…
Handling of Small Scale Structures of the Irradiance Field for Solar Energy System Analysis – A Review
2016
Abstract Satellite derived irradiance information currently approaches a status as standard input for solar energy system analysis. Due to intrinsic limitations in spatial and temporal resolution, these data fail to give information of the full dynamics of the irradiance field in space and time. The analysis of systems with sensibility to details of the temporal evolution of the irradiance field and systems with sensibility to the spatial inhomogeneity of the field require knowledge of its fine-structured. Thus, methods for a respective enhancement of the satellite derived data are needed. This contribution presents various approaches discussed for setting up respective input data.
Chronic neural probe for simultaneous recording of single-unit, multi-unit, and local field potential activity from multiple brain sites
2017
Drug resistant focal epilepsy can be treated by resecting the epileptic focus requiring a precise focus localisation using stereoelectroencephalography (SEEG) probes. As commercial SEEG probes offer only a limited spatial resolution, probes of higher channel count and design freedom enabling the incorporation of macro and microelectrodes would help increasing spatial resolution and thus open new perspectives for investigating mechanisms underlying focal epilepsy and its treatment. This work describes a new fabrication process for SEEG probes with materials and dimensions similar to clinical probes enabling recording single neuron activity at high spatial resolution.Polyimide is used as a bi…
High Resolution-magic Angle Spinning NMR Study of Olive Leaves
2013
In recent years HR-MAS 1H NMR spectroscopy has proven to be a useful tool for the rapid determination of the metabolic profile of several solid and semisolid foods, such as fruits and vegetables, cheese and meat. Olive leaves are today recognized as direct sources of bioactive compounds and natural antioxidants (flavonoids, secoiridoids) suitable as food additives, and their extracts form the basis of beauty care products and pharmaceutical supplements. Thus, olive leaves are emerging as a new and potentially important product for olive tree growing regions. In this report we present the application of 1H and 13C HR-MAS 1D and 2D NMR spectroscopy for the characterization and analysis of tri…
Monitoring deforestation and forest degradation linking high-resolution satellite data and field data in the context of REDD+. A case of Tanzania
2017
El principal objetivo de este doctorado es apoyar el desarrollo de un sistema nacional de monitoreo forestal en Tanzania para informar sobre las emisiones actuales e históricas derivadas de la deforestación y la degradación forestal. El marco de la tesis se centra específicamente en el emergente contexto internacional de la iniciativa REDD + (Reducción de Emisiones por Deforestación y Degradación) de las Naciones Unidas, bajo la cual los países pueden obtener subsidios financieros para demostrar que están reduciendo sus emisiones de carbono de tierras forestales con respecto a su práctica histórica reciente. La investigación se centró en cinco áreas de investigación: La parte (1) revisa los…