Search results for " s.p.a."

Complejos de ligandos azamacrocíclicos como miméticos de enzimas con actividad antioxidante

2019

The imbalance between the generation and clearance of reactive oxygen species (ROS) causes oxidative stress, which is related to a variety of health issues that include neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease. In order to remove ROS, living organisms have developed a battery of protective enzymes, such as superoxide dismutases (SODs). Although SOD enzymes have shown therapeutic efficacy, their use has severe drawbacks such as the absence of oral activity, immunogenicity, short half-life and low cell permeability. Therefore, low-molecular weight mimetics may offer better outcomes regarding properties such as lack of antigenicity, good tissue penetrance, high s…

External and internal elimination of supernumerary larvae in the whitefly parasitoid Eretmocerus mundus Mercet (Hymenoptera: Aphelinidae)

2008

Abstract The solitary parasitoid Eretmocerus mundus Mercet (Hymenoptera: Aphelinidae) is one of the key biological control agents of the whitefly Bemisia argentifolii Bellows & Perring, also known as B. tabaci (Gennadius) B-biotype (Homoptera: Aleyrodidae). We present new information on its biology, and particularly about larval elimination during the first instar in cases of superparasitism. For the first time, physical elimination of supernumerary larvae was observed, both outside and inside the host. These findings are documented with confocal microscopy images and video recordings. We observed more than 350 B. argentifolii nymphs, parasitized with one, two or more than two larvae. Physi…

Nuevos ligandos poliamínicos de tipo escorpiando para aplicaciones biomédicas

2016

La presente Tesis Doctoral nace en el marco del proyecto Consolider titulado “Aplicación de la Química Supramolecular al Diseño, Síntesis y Estudio de Compuestos Bioactivos de Acción Antiinflamatoria, Antitumoral o Antiparasitaria” (CSD2010-00065, BOE del 27 de febrero de 2010). El principal objetivo de este proyecto era la formación en España de un grupo de investigación multidisciplinar dedicado a la Química Médica Supramolecular (SUPRAMED, www.supramedic.com) que centraría sus esfuerzos, como su nombre indica, en el desarrollo de nuevos agentes terapéuticos con actividad antiparasitaria, antiinflamatoria o antitumoral. Como miembro investigador en este proyecto (dentro del grupo de Quími…

Simone Weil. L’infinito invocare: bellezza e soprannaturale

2001

Fungal root endophyte associations of plants endemic to the Pamir Alay Mountains of Central Asia.

2011

The fungal root endophyte associations of 16 species from 12 families of plants endemic to the Pamir Alay Mountains of Central Asia are presented. The plants and soil samples were collected in Zeravshan and Hissar ranges within the central Pamir Alay mountain system. Colonization by arbuscular mycorrhizal fungi (AMF) was found in 15 plant species; in 8 species it was of the Arum type and in 4 of the Paris type, while 3 taxa revealed intermediate arbuscular mycorrhiza (AM) morphology. AMF colonization was found to be absent only in Matthiola integrifolia, the representative of the Brassicaceae family. The AM status and morphology are reported for the first time for all the species analyzed a…

The genetic heritage of Alpine local cattle breeds using genomic SNP data

2020

Abstract Background Assessment of genetic diversity and population structure provides important control metrics to avoid genetic erosion, inbreeding depression and crossbreeding between exotic and locally-adapted cattle breeds since these events can have deleterious consequences and eventually lead to extinction. Historically, the Alpine Arc represents an important pocket of cattle biodiversity with a large number of autochthonous breeds that provide a fundamental source of income for the entire regional economy. By using genotype data from medium-density single nucleotide polymorphism (SNP) arrays, we performed a genome-wide comparative study of 23 cattle populations from the Alpine Arc an…

Binding Profiles of Self-Assembled Supramolecular Cages from ESI-MS Based Methodology

2018

Confined molecular environments have peculiar characteristics that make their properties unique in the field of biological and chemical sciences. In recent years, advances in supramolecular capsule and cage synthesis have presented the possibility to interpret the principles behind their self‐assembly and functions, which has led to new molecular systems that display outstanding properties in molecular recognition and catalysis. Herein, we report a rapid method based on ESI‐MS to determine the binding profiles for linear saturated dicarboxylic acids in a series of different cages. The cages were obtained by self‐assembly of modified tris(pyridylmethyl)amine (TPMA) complexes and diamines cho…

IS CALORIMETRY A CRUCIAL TECHNIQUE FOR STUDYING INNOVATIVE NANOMATERIALS?

2012

It is well known that calorimetry is a powerful technique to determine the complete energetics of interaction processes. Unfortunately, over the years the calorimetry has been applied to restricted fields so that it has been underemployed in studying smart nanomaterials (polypseudorotaxanes, polymeric aggregates, surface functionalized nanoparticles, nanocomposites, etc.) to which a tremendous scientific interest has been recently addressed. Within this topic some relevant recent results from our laboratory will be described in the following. As concerns the supramolecular chemistry field, we exploited strategies to design stable and stimuli responsive polypseudorotaxanes based on cyclodext…

Calorimetry: a Valuable Tool for Emerging Smart Nanomaterials

2012

It is well known that calorimetry is a powerful technique to determine the complete energetics (standard free energy, enthalpy and entropy) of interaction processes. We are now assisting to the increment of the use of nano-calorimetry, which appears rather versatile because it can evidence weak interactions quickly and accurately and, furthermore, needs very small amounts of material. Unfortunately, over the years the calorimetry has been applied to restricted fields so that it has been underemployed in studying smart nanomaterials (polypseudorotaxanes, polymeric aggregates, surface functionalized nanoparticles, nanocomposites, etc.) to which a tremendous scientific interest has been recent…

Nitrogen-Doped Carbon Nanodots-Ionogels: Preparation, Characterization, and Radical Scavenging Activity

2018

Hybrid diimidazolium-based ionogels were obtained by dispersing nitrogen-doped carbon nanodots (NCNDs) in ionic liquid (IL) solutions and by using dicationic organic salts as gelators. The properties of the NCND-ionogels were studied in terms of thermal stability, mechanical strength, morphology, rheological, and microscopic analyses. Insights into the formation of the hybrid soft material were attained from kinetics of sol-gel phase transition and from estimating the size of the aggregates, obtained from opacity and resonance light-scattering measurements. We demonstrate that, on one hand, NCNDs were able to favor the gel formation both in the presence of gelating and nongelating ILs. On t…