Search results for " secondary"
showing 10 items of 692 documents
Convergence for varying measures in the topological case
2023
In this paper convergence theorems for sequences of scalar, vector and multivalued Pettis integrable functions on a topological measure space are proved for varying measures vaguely convergent.
On the Dimension of Kakeya Sets in the First Heisenberg Group
2021
We define Kakeya sets in the Heisenberg group and show that the Heisenberg Hausdorff dimension of Kakeya sets in the first Heisenberg group is at least 3. This lower bound is sharp since, under our definition, the $\{xoy\}$-plane is a Kakeya set with Heisenberg Hausdorff dimension 3.
Spatial Besov regularity for stochastic partial differential equations on Lipschitz domains
2010
We use the scale of Besov spaces B^\alpha_{\tau,\tau}(O), \alpha>0, 1/\tau=\alpha/d+1/p, p fixed, to study the spatial regularity of the solutions of linear parabolic stochastic partial differential equations on bounded Lipschitz domains O\subset R^d. The Besov smoothness determines the order of convergence that can be achieved by nonlinear approximation schemes. The proofs are based on a combination of weighted Sobolev estimates and characterizations of Besov spaces by wavelet expansions.
History teaching in Finnish general upper secondary schools: Objectives and practices
2019
In Finland, the trend towards a new kind of history teaching emphasizing the understanding of historical knowledge and historical thinking skills began in the mid-1990s, when history teaching objectives were defined much more broadly in the curriculum than previously. In this article, we examine how, in over twenty years since the changes in curriculum objectives were made, general upper secondary school teachers have come to value the curriculum objectives of history teaching and how these have impacted on their teaching. The data for this article were collected by a semi-structured survey in 2016. Using counts, percentages, means, standard deviations and medians, a descriptive exploration…
An empirical test of neighbourhood effect and safe-site effect in abandoned Mediterranean vineyards
2011
The importance of both neighbourhood effect and safe-site effect for the colonization of Mediterranean old fields by woody plants was investigated. Using a transect approach, we recorded colonization of 21 species of woody plants on abandoned, terraced vineyards on Pantelleria Island (Sicily) in dependence from neighbouring terraces in older succession stages (Maquis) and available safe sites for seedling establishment (former crop plant, terrace wall). With a paired design of four treatments, including presence/absence of adjacent older successional stages, and North-/South-facing slopes, a neighbourhood effect could be shown for both expositions if the transect started from an adjacent fi…
Fluidizing the Membrane by a Local Anesthetic: Phenylethanol Affects Membrane Protein Oligomerization
2010
The exact mechanism of action of anesthetics is still an open question. While some observations suggest specific anesthetic-protein interactions, nonspecific perturbation of the lipid bilayer has also been suggested. Perturbations of bilayer properties could subsequently affect the structure and function of membrane proteins. Addition of the local anesthetic phenylethanol (PEtOH) to model membranes and intact Escherichia coli cells not only affected membrane fluidity but also severely altered the defined helix-helix interaction within the membrane. This experimental observation suggests that certain anesthetics modulate membrane physical properties and thereby indirectly affect transmembran…
(19)F NMR screening of unrelated antimicrobial peptides shows that membrane interactions are largely governed by lipids.
2014
AbstractMany amphiphilic antimicrobial peptides permeabilize bacterial membranes via successive steps of binding, re-alignment and/or oligomerization. Here, we have systematically compared the lipid interactions of two structurally unrelated peptides: the cyclic β-pleated gramicidin S (GS), and the α-helical PGLa. 19F NMR was used to screen their molecular alignment in various model membranes over a wide range of temperatures. Both peptides were found to respond to the phase state and composition of these different samples in a similar way. In phosphatidylcholines, both peptides first bind to the bilayer surface. Above a certain threshold concentration they can re-align and immerse more dee…
Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix.
1990
The processes of transcription and posttranscription are assumed to proceed in close association with the nuclear matrix. In this study we demonstrated that Tat, the trans-activating protein from human immunodeficiency virus type 1 (HIV-1), binds both to the TAR region of the nascent HIV mRNAs and the nuclear matrix with high affinity. Both North/Western blotting experiments and nitrocellulose binding studies revealed that Tat binds with an association constant (K alpha) of approximately 1 x 10(9) M-1 to the TAR segment of HIV RNA; binding of Tat to this sequence which is present between position 32 and 82 downstream from the TATA box was also confirmed by gel retardation assays. Binding of…
Induction of immunologic memory following primary vaccination with the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate …
2011
Background Induction of immunologic memory was assessed following primary vaccination with 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV). Methods Infants were randomized (1:1) to receive 3 doses of PHiD-CV or 7vCRM (7-valent CRM197-conjugated pneumococcal conjugate vaccine [PCV]) at 2, 3, and 4 months of age followed by 23-valent pneumococcal polysaccharide vaccine (23vPS) booster dose at 11 to 14 months of age. Pneumococcal geometric mean antibody concentrations (GMCs) and opsonophagocytic activity (OPA) geometric mean titers were measured. Results Postprimary immune responses were consistent with those in previous PHiD-CV and 7vCRM studies…
Immunogenicity of routinely used childhood vaccines when coadministered with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D…
2009
Background The choice of non-typeable Haemophilus influenzae Protein D as main carrier protein in the candidate 10-valent pneumococcal conjugate vaccine (PHiD-CV, GlaxoSmithKline Biologicals), was driven in part to avoid carrier-mediated suppression and possible bystander interference with coadministered vaccines. Immunogenicity data from 3 primary and 2 booster vaccination studies were assessed for possible impacts of PHiD-CV coadministration on immune responses to routinely administered childhood vaccines, in comparison to 7-valent pneumococcal conjugate vaccine (7vCRM) coadministration. Methods Randomized, controlled studies in which PHiD-CV or 7vCRM vaccines were coadministered with DTP…