Search results for " selection"
showing 10 items of 1271 documents
Does chemotherapy prevent HCV-related hepatocellular carcinoma? Cons.
2010
The accuracy and the reliability of well-recognized clinical, virologic, histologic, and molecular risk factors for hepatocellular carcinoma (HCC) are still insufficient. Thus, accurate risk prediction of cancer development in individual patients with the aim of selecting high risk cohorts of patients for HCC chemoprevention programs remains an elusive goal. Future directions in chemoprevention of HCC will be in the development of molecular risk models and of new chemopreventive agents. Studies examining multiple genes and proteins (genomics and proteomics) in the same HCCs will be required to evaluate this possibility thoroughly. A strategy aiming at preventing chronic liver disease of any…
Risk of lymph node metastasis in submucosal esophageal cancer: a review of surgically resected patients
2011
Endoscopic local procedures are increasingly applied in patients with superficial esophageal cancer as an alternative to radical oncologic resection. The objective of this article is to determine the risk of nodal metastases in submucosal (sm) esophageal cancer, comparing the two predominating histologic tumor types, squamous cell cancer (SCC) and adenocarcinoma (ADC).A query of PubMed, MEDLINE, Embase and Cochrane Library (1980-2009) using predetermined search terms revealed 675 abstracts, of which 485 full-text articles were reviewed. A total of 105 articles met the selection criteria. A review of article references and consultation with experts revealed additional articles for inclusion.…
How to find the Ariadne's thread in the labyrinth of salvage treatment options for metastatic colorectal cancer?
2014
Abstract: Since a chance for cure was found out in metastatic colorectal cancer (mCRC) patients undergoing a resection of liver and lung metastases, high tumor shrinkage by chemotherapy regimens and their combination with targeted agents have been addressed in potentially resectable mCRC. However, most mCRC patients cannot reach this opportunity because of tumor burden or metastatic sites. For these patients a salvage systemic therapy could be offered to prolong survival. To date, a huge number of clinical trials provided some evidences for the achievement of this goal. A lot of chemotherapeutic regimens in combination with biological therapies are now available. We tried to propose a simpl…
Pharmacogenetics of treatments for pancreatic cancer
2019
Introduction: Despite clinical efforts, pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The scarcity of effective therapies can be reflected by the lack of reliable biomarkers to adapt anticancer drugs prescription to tumors’ and patients’ features. Areas covered: Pharmacogenetics should provide the way to select patients who may benefit from a specific therapy that best matches individual and tumor genetic profile, but it has not yet led to gains in outcome. This review describes PDAC pharmacogenetics findings, critically reappraising studies on polymorphisms and -omics profiles correlated to response to gemcitabine, FOLFIRINOX, and nab-paclitaxel combinations, as well as l…
Transplantation in follicular lymphoma: not "yes or no" but "whom and when".
2013
After years of debate, the question as to what is the optimal use of transplantation strategies in indolent lymphoma remains controversial. In the July issue of Haematologica, a study was published by the EBMT Lymphoma Working Party that aims to define indications for hematopoietic stem cell
Traitement 3D de nuages de points basé sur la connaissance
2013
The modeling of real-world scenes through capturing 3D digital data has proven to be both useful andapplicable in a variety of industrial and surveying applications. Entire scenes are generally capturedby laser scanners and represented by large unorganized point clouds possibly along with additionalphotogrammetric data. A typical challenge in processing such point clouds and data lies in detectingand classifying objects that are present in the scene. In addition to the presence of noise, occlusionsand missing data, such tasks are often hindered by the irregularity of the capturing conditions bothwithin the same dataset and from one data set to another. Given the complexity of the underlying…
Joint Power Allocation and Link Selection for Multi-Carrier Buffer Aided Relay Network
2019
In this paper, we present a joint power allocation and adaptive link selection protocol for an orthogonal frequency division multiplexing (OFDM)-based network consists of one source node i.e., base station (BS), one destination node i.e., (MU) and a buffer aided decode and forward (DF) relay node. Our objective is to maximize the average throughput of the system via power loading over different subcarriers at source and relay nodes. A separate power budget is assumed at each transmitting node to make the system more practical. In order to form our solution more tractable, a decomposition framework is implemented to solve the mixed integer optimization problem. Further, less complex suboptim…
Distributed Resource Allocation for Energy Efficiency in OFDMA Multicell Networks with Wireless Power Transfer
2019
In this paper, an energy-efficient resource allocation problem is investigated for the wireless power transfer (WPT)-enabled OFDMA multicell networks. In the considered system, multiple base stations (BSs) with a large number of antennas are responsible to provide WPT in the downlink, and the users can recycle and utilize the received energy for uplink data transmission. The role of BS is to execute WPT; thus, there are no data transmissions in the downlink. A time-division protocol is considered to divide the time of downlink WPT and uplink wireless information transfer into separate time slots. With the objective to improve the energy efficiency, we propose the time, subcarrier, and power…
An user friendly Real Options based Model to Optimize Pharmaceutical R&D Portfolio
2013
Pharmaceutical industry pays great attention to its R&D process because it is a long, dynamic, very expensive, and uncertain process. On the other hand this process can be modelled as a step-wise process and each stage allows to achieve better information and generally lower uncertainty. In order to build up the best portfolio a tool able to capture the intrinsic flexible nature of the process should be selected: real options analysis has this characteristic but as widely demonstrated in literature, is narrowed to very limited cases because its perceived complexity. Basing on OptFolio, a model available in literature, this paper proposes an user friendly programming model based on Real Opti…
The labour market consequences of self-employment spells:European evidence
2008
Hundreds of thousands of Europeans enter self-employment each year, but because self-employment spells are typically brief, many of them exit soon after entry. We examine how those who return to paid-employment fare on the labour market using the European Community Household Panel (ECHP). Like earlier evidence for the US, ours indicate that, in general, brief spells of self-employment do not increase average hourly earnings upon return to paid-employment. For highly educated men, an additional year of self-employment actually decreases their earnings by 4-5% relative to a year of continued wage employment. We also find that brief spells of self-employment are associated with increased proba…