6533b832fe1ef96bd129a4b2
RESEARCH PRODUCT
How to find the Ariadne's thread in the labyrinth of salvage treatment options for metastatic colorectal cancer?
Christian RolfoAntonio RussoMarc PeetersGiuseppe Brontesubject
Oncologymedicine.medical_specialtyLung NeoplasmsColorectal cancerSettore MED/06 - Oncologia Medicamedicine.medical_treatmentClinical BiochemistrySalvage treatmentTumor burdenalgorithm chemotherapy metastatic colorectal cancer salvage treatment target therapySystemic therapyResectionInternal medicineDrug DiscoveryAntineoplastic Combined Chemotherapy ProtocolsmedicineHepatectomyHumansMolecular Targeted TherapyPneumonectomyBiologyPharmacologySalvage TherapyChemotherapybusiness.industryPatient SelectionTumor shrinkageLiver NeoplasmsMetastasectomymedicine.diseasedigestive system diseasesNeoadjuvant TherapyClinical trialTreatment OutcomeChemotherapy AdjuvantCritical PathwaysHuman medicinebusinessColorectal NeoplasmsEngineering sciences. TechnologyAlgorithmsdescription
Abstract: Since a chance for cure was found out in metastatic colorectal cancer (mCRC) patients undergoing a resection of liver and lung metastases, high tumor shrinkage by chemotherapy regimens and their combination with targeted agents have been addressed in potentially resectable mCRC. However, most mCRC patients cannot reach this opportunity because of tumor burden or metastatic sites. For these patients a salvage systemic therapy could be offered to prolong survival. To date, a huge number of clinical trials provided some evidences for the achievement of this goal. A lot of chemotherapeutic regimens in combination with biological therapies are now available. We tried to propose a simple way to choose the best options and to plan an optimal sequence of treatments. This tool could help the oncologists worldwide to better and easily manage mCRC patients who need salvage systemic therapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 |