Search results for " set"

Bel-Air, Sénas (Bouches-du-Rhône) : a Late Neolithic open-air settlement site on the eastern foot-slopes of the Massif des Alpilles. Preliminary resu…

2014

This article is the first presentation of the excavation results following the developer-led archaeological project carried out between July and August 2012 at the site of Bel-Air, Sénas, Bouches-du-Rhône. Our current understanding of the diverse archaeological remains show that a densely occupied settlement existed within a relatively short-lived period during the second phase of the Late Neolithic in Provence, between 2880 and 2490 BC. The occupation is characterised by several phases of activity, which are at this stage of research, difficult to refine, but all of them being associated with the Couronnien group.

Stationary sets and asymptotic behavior of the mean curvature flow with forcing in the plane

2020

We consider the flat flow solutions of the mean curvature equation with a forcing term in the plane. We prove that for every constant forcing term the stationary sets are given by a finite union of disks with equal radii and disjoint closures. On the other hand for every bounded forcing term tangent disks are never stationary. Finally in the case of an asymptotically constant forcing term we show that the only possible long time limit sets are given by disjoint unions of disks with equal radii and possibly tangent. peerReviewed

Stationary sets of the mean curvature flow with a forcing term

2020

We consider the flat flow approach for the mean curvature equation with forcing in an Euclidean space $\mathbb R^n$ of dimension at least 2. Our main results states that tangential balls in $\mathbb R^n$ under any flat flow with a bounded forcing term will experience fattening, which generalizes the result by Fusco, Julin and Morini from the planar case to higher dimensions. Then, as in the planar case, we are able to characterize stationary sets in $\mathbb R^n$ for a constant forcing term as finite unions of equisized balls with mutually positive distance.

Volume preserving mean curvature flows near strictly stable sets in flat torus

2021

In this paper we establish a new stability result for the smooth volume preserving mean curvature flow in flat torus $\mathbb T^n$ in low dimensions $n=3,4$. The result says roughly that if the initial set is near to a strictly stable set in $\mathbb T^n$ in $H^3$-sense, then the corresponding flow has infinite lifetime and converges exponentially fast to a translate of the strictly stable (critical) set in $W^{2,5}$-sense.

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

2017

Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also induced differentiation. From these, the secondary chemical screen identified SETD8, the H4K20me1 methyltransferase, as a druggable NB target. Functional studies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by decreasing p53K382me1, leading to activation of the p53 canonical pathway. I…

High-SETD8 inactivates p53 in neuroblastoma

2017

Differences in wage determination in the Eurozone: A challenge to the resilience of the common currency

2019

Abstract Different developments in wages and unit labor costs across countries can reduce the synchronization of business cycles within a currency area and therefore be a potential source of asymmetric shocks and/or asymmetric response to a common shock. In this paper, we use novel econometric methods to identify differences and similarities in wage determination across Eurozone countries. Results show that wages have different determinants across euro area countries, among which two relatively distinct groups can be identified. In particular, wages in Germany, Austria, Belgium, Luxembourg, the Netherlands and Finland behave more similarly, are less sticky and respond more to macroeconomic …

A fuzzy approach to multidimensional material deprivation measurement: the case of foreigners living in Italy

2014

This paper provides a new approach to the measurement of multidimensional material deprivation, based on partial order theory and on fuzzy set measurement. The main feature of the methodology is that the information needed for the deprivation assessment is extracted directly from the relational structure of the dataset, avoiding any kind of scaling and not proper aggregation procedure, so as to respect the measurement level of the data. An empirical illustration, using data from a special EU-SILC survey on migrants in Italy, provides a new insight on the material deprivation of foreigners living in Italy

Partial-order reduction for parity games and parameterised Boolean equation systems

2022

AbstractIn model checking, reduction techniques can be helpful tools to fight the state-space explosion problem. Partial-order reduction (POR) is a well-known example, and many POR variants have been developed over the years. However, none of these can be used in the context of model checking stutter-sensitive temporal properties. We propose POR techniques for parity games, a well-established formalism for solving a variety of decision problems, including model checking. As a result, we obtain the first POR method that is sound for the full modal $$\upmu $$ μ -calculus. We show how our technique can be applied to the fixed point logic called parameterised Boolean equation systems, which pro…

Monotone generalized nonlinear contractions and fixed point theorems in ordered metric spaces

2011

The purpose of this paper is to present some fixed point theorems for T -weakly isotone increasing mappings which satisfy a generalized nonlinear contractive condition in complete ordered metric spaces. As application, we establish an existence theorem for a solution of some integral equations.