Search results for " severity"

showing 10 items of 284 documents

Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units

2021

Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. I…

Drug Resistancemedicine.disease_causeSeverity of Illness Indexlaw.invention0302 clinical medicineENTEROBACTERIACEAElawDrug Resistance Multiple BacterialMedicine and Health SciencesPharmacology (medical)Cross InfectionbiologyBacterialAntimicrobialIntensive care unitAnti-Bacterial AgentsCommunity-Acquired InfectionsEuropeIntensive Care UnitsAnti-Bacterial Agents; Community-Acquired Infections; Critical Illness; Cross Infection; Europe; Humans; Intensive Care Units; Intraabdominal Infections; Microbial Sensitivity Tests; Peritonitis; Sepsis; Severity of Illness Index; Drug Resistance Multiple BacterialESCHERICHIA-COLI030220 oncology & carcinogenesisKLEBSIELLA-PNEUMONIAEBLOOD-STREAM INFECTIONSPYELONEPHRITISMultiplemedicine.medical_specialtyCritical IllnessMicrobial Sensitivity TestsPeritonitisEnterococcus faecalisNO03 medical and health sciencesIntra‑abdominal InfectionsAntibiotic resistanceFOODSepsisIntensive careInternal medicinemedicineHumansFLUOROQUINOLONE RESISTANCEPseudomonas aeruginosabusiness.industrySeptic shockMORTALITYbiology.organism_classificationmedicine.diseaseRISK-FACTORSIntraabdominal Infectionsbusiness030217 neurology & neurosurgeryEnterococcus faecium
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Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease

2009

BACKGROUND: The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the basal ganglia to the thalamus and the cortical motor areas. However, not only striatothalamocortical motor circuits but also other interconnected pathways could be implicated in its pathogenesis. METHODS: In a series of experiments, we applied repetitive transcranial magnetic stimulation (rTMS) over the lateral cerebellum in a group of patients with advanced Parkinson disease, to investigate whether modulation of cerebellothalamocortical circuits…

Dyskinesia Drug-InducedLevodopaCerebellummedicine.medical_treatmentCTBStmSeverity of Illness IndexrehabilitationNOLevodopaNeural PathwaySeverity of Illness Index; Analysis of Variance; Levodopa; Dyskinesia Drug-Induced; Humans; Cerebellum; Aged; Neural Inhibition; Thalamus; Motor Cortex; Parkinson Disease; Evoked Potentials Motor; Neural Pathways; Middle Aged; Neuronal Plasticity; Transcranial Magnetic StimulationThalamusCerebellumNeural PathwaysBasal gangliamedicineHumansEvoked PotentialsThalamuAgedAnalysis of VarianceNeuronal PlasticityDyskinesiaMotor CortexNeural InhibitionParkinson DiseaseMiddle AgedEvoked Potentials MotorTranscranial Magnetic StimulationAged; Analysis of Variance; Cerebellum; Drug-Induced Dyskinesia; Evoked Potentials; Motor; Humans; Levodopa; Middle Aged; Motor Cortex; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Parkinson Disease; Severity of Illness Index; Thalamus; Transcranial Magnetic StimulationTranscranial magnetic stimulationmedicine.anatomical_structureMotorDyskinesiaDrug-Inducedparkinson's diseaseSettore MED/26 - NeurologiaDrug-Induced DyskinesiaNeurology (clinical)Primary motor cortexmedicine.symptomPsychologyNeuroscienceHumanMotor cortexmedicine.drugNeurology
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Determinants of COVID-19 Vaccine Rollouts and Their Effects on Health Outcomes

2022

Background Vaccination against the coronavirus disease (SARS-CoV-2) is understood to be the key way out of the COVID-19 pandemic. Limited evidence exists on the determinants of vaccine rollouts and their health effects at the country level. Objective Examine the determinants of COVID-19 vaccine rollouts and their effects on health outcomes. Methods Ordinary least squares regressions with standard errors clustered at the country level for Cross-section and Panel daily data of vaccinations and various health outcomes (new COVID-19 cases, fatalities, intensive care unit (ICU) admissions) for an unbalanced sample of about 200 countries during the period 16 December 2020 to 20 June 2021. Results…

Economics and Econometricsand (iii) COVID-19 cases in neighboring countries can lead to an increase in a country's domestic caseload and hamper efforts in taming its own local outbreak. Conclusions: By providing an early broad overview of the quantitative empirical estimates of the determinants of vaccine rollouts and the effects of COVID-19 vaccines our paper can help policymakers make informed decisions about local and global distributions of vaccines as well as related policy tools such as containment measure.Coronavirus disease 2019 (COVID-19)business.industryHealth PolicyNational accountsOutbreakGeneral Medicine(ii) vaccine deployment significantly reduces new COVID-19 infections Intensive Care Unit (ICU) admissions and fatalities and is more effective when coupled with stringent containment measures or when a country is experiencing a large outbreakVaccination against the coronavirus disease (SARS-CoV-2) is understood to be the key way out of the COVID-19 pandemic. Limited evidence exists on the determinants of vaccine rollouts and their health effects at the country level. Objective: Examine the determinants of COVID-19 vaccine rollouts and their effects on health outcomes. Methods: Ordinary least squares regressions with standard errors clustered at the country level for Cross-section and Panel daily data of vaccinations and various health outcomes (new COVID-19 cases fatalities intensive care unit (ICU) admissions) for an unbalanced sample of about 200 countries during the period 16 December 2020 to 20 June 2021. Results: We find evidence that: (i) early vaccine procurement domestic production of vaccines the severity of the pandemic a country's health infrastructure and vaccine acceptance are significant determinants of the speed of vaccination rolloutHealth outcomesIntensive care unitlaw.inventionVaccinationProcurementlawEnvironmental healthPandemicGeneral Earth and Planetary SciencesMedicinebusinessGeneral Environmental ScienceIMF Working Papers
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Do fire severity effects on soil change in space and time in the short-term? What ash tells us

2013

n the absence of data, the impact of fire, especially wildfires, is measured analysing the fire severity. This post-fire assessment is very useful because allow to identify the degree of destruction imposed by the fire. Among the techniques used to determine fire severity, ash colour is often used, that permit identify the degree of organic matter consumption (darker ash uncompleted combustion, lighter ash completed combustion). The objective of this paper was observed if fire severity changes in space and time, according to ash colour analysis, applying an index. The ash colour analysis was carried out one and fifteen days after the fire. In this area we identified ash with four different …

Fire severity indexAsh colorFire severitytechnology industry and agriculturemacromolecular substancesAsh redistributionlcsh:Science (General)complex mixturesSpatial correlationlcsh:Q1-390
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Factors influencing psychological well-being in patients with Parkinson's disease.

2017

Background Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale. Objectives To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates. Methods This article reports data of patients' perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional study conducted in Italian PD patients (FORTE Study). We tested possible relatio…

Genetics and Molecular Biology (all)MaleParkinson's diseaseEmotionsPoison controlSocial Scienceslcsh:MedicinePathology and Laboratory MedicineBiochemistrySeverity of Illness IndexAged; Depression; Fatigue; Female; Humans; Italy; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)0302 clinical medicineMathematical and Statistical TechniquesQuality of lifeSurveys and QuestionnairesMedicine and Health SciencesMedicinePsychologySurveys and Questionnaire030212 general & internal medicinelcsh:ScienceDepression (differential diagnoses)FatigueMultidisciplinaryMovement DisordersDepressionNeurodegenerative DiseasesParkinson DiseaseMiddle AgedPsychiatric Status Rating ScalehumanitiesNeurologyItalyPhysical SciencesFemaleStatistics (Mathematics)Clinical psychologyResearch ArticleHumanResearch and Analysis Methods03 medical and health sciencesSigns and SymptomsDiagnostic MedicineSeverity of illnessInjury preventionMental Health and PsychiatryHumansStatistical MethodsAgedPsychiatric Status Rating Scalesparkinson's disease quality of lifeAnalysis of VarianceBiochemistry Genetics and Molecular Biology (all)business.industryMood Disorderslcsh:RBeck Depression InventoryBiology and Life Sciencesmedicine.diseaseHealth CareAgricultural and Biological Sciences (all)Psychological well-beingAged; Depression; Fatigue; Female; Humans; Italy; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Quality of Life; Severity of Illness Index; Surveys and QuestionnairesQuality of Lifelcsh:QbusinessSleep Disorders030217 neurology & neurosurgeryMathematicsPLoS ONE
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Adverse Clinical Events and Mortality During Hospitalization and 3 Months After Discharge in Cognitively Impaired Elderly Patients

2012

BACKGROUND: Controversial findings are reported on hospital outcome in cognitively impaired patients. The aim of this study was to explore mortality risk according to cognitive status during hospitalization and after 3 months in elderly patients. METHODS: Sixty-six internal medicine and geriatric wards in Italy participated in the "Registry Politerapie SIMI (REPOSI)" during 2010. Of the 1,380 in-patients, aged 65 and older enrolled, 1,201 were included. Cognition was evaluated with the Short Blessed Test (SBT). Logistic regression was used to evaluate the association of questionable and impaired cognition (according to SBT cutoff points) with mortality during hospitalization and at follow-u…

GerontologyMaleARDSTime FactorsSettore MED/09 - Medicina InternaActivities of Daily Living Aged Aged; 80 and over Cognition Disorders; diagnosis/mortality Female Geriatric Assessment; methods Hospital Mortality Hospitalization; statistics /&/ numerical data Humans Intelligence Tests Italy; epidemiology Logistic Models Male Odds Ratio Patient Discharge; statistics /&/ numerical data Risk Assessment; methods Risk Factors Severity of Illness Index Time Factorsdiagnosis/mortalitycognitively impaired patients; Registry Politerapie SIMI (REPOSI); Elderly patients;Logistic regressionSeverity of Illness IndexDementia; agingRisk FactorsActivities of Daily Living80 and overOdds RatioHospital MortalityAged 80 and overIntelligence TestsAdverse clinical eventsCognitionSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatrichePatient Dischargestatistics /&/ numerical dataHospitalizationItalyFemaleepidemiologyElderly patientmedicine.medical_specialtyelderly patientsRisk AssessmentOddsmethodsNOInternal medicinemedicineDementiaHumansRegistry Politerapie SIMI (REPOSI)Adverse effectGeriatric Assessmentcognitive functionAgedbusiness.industryagingOdds ratiocognitively impaired patientmedicine.diseasemortalityConfidence intervalhospital admissionLogistic ModelsAdverse clinical events; elderly patients; cognitive function; mortality; hospital admissionDementiaGeriatrics and GerontologybusinessCognition Disorders
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Implementation of the Frailty Index in hospitalized older patients: Results from the REPOSI register

2018

Abstract Background Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. Methods Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses. Variables recorded at the hospital admission (including socio-demographic, physical, cognitive, functional and clinical factors) were used to compute the FI. The prognostic impa…

GerontologyMaleMultivariate analysisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Internal MedicinePhysical and cognitive impairmentPsychological interventionPredictive Value of TestSeverity of Illness Index0302 clinical medicineInternal medicine and geriatric wardsInterquartile rangeFrailty Internal medicine and geriatric wards Multimorbidity Physical and cognitive impairment80 and overMedicine030212 general & internal medicineProspective StudiesHospital MortalityProspective cohort studyMultivariate AnalysiAged 80 and overFrailtyPrognosisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness IndexHospitalizationItalyPredictive value of testsRegression AnalysisFemaleSurvival AnalysiCohort studyHumanPrognosiFrail ElderlyFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness Index; Internal MedicineSocio-culturaleRegression Analysi03 medical and health sciencesPredictive Value of TestsSeverity of illnessInternal MedicineHumansGeriatric AssessmentSurvival analysisAgedbusiness.industryMultimorbiditySurvival AnalysisInternal medicine and geriatric wardProspective StudieMultivariate Analysisbusiness030217 neurology & neurosurgery
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Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas. The PRINTO multinational qual…

2006

OBJECTIVES: To compare health-related quality of life (HRQL) and to identify clinical determinants for poor HRQL of patients with juvenile idiopathic arthritis (JIA) coming from three geographic areas.METHODS: The HRQL was assessed through the Child Health Questionnaire (CHQ). A total of 30 countries were included grouped in three geographic areas: 16 countries in Western Europe; 10 in Eastern Europe; and four in Latin America. Potential determinants of poor HRQL included demographic data, physician's and parent's global assessments, measures of joint inflammation, disability as measured by Childhood Health Assessment Questionnaire (CHAQ) and erythrocyte sedimentation rate. Poor HRQL was de…

GerontologyQuality of lifeCross-Cultural ComparisonMalemedicine.medical_specialtyDisability; Juvenile idiopathic arthritis; Pain; Quality of life; Adolescent; Arthritis Juvenile; Child; Cross-Cultural Comparison; Cross-Sectional Studies; Disability Evaluation; Europe; Europe Eastern; Female; Humans; Latin America; Male; Pain Measurement; Severity of Illness Index; Quality of LifeAdolescentCross-sectional studyPainJuvenileEasternSeverity of Illness IndexDisability EvaluationQuality of life (healthcare)RheumatologySeverity of illnessmedicineGlobal healthHumansPharmacology (medical)Europe EasternChildPain MeasurementDisabilitybusiness.industryArthritisJuvenile idiopathic arthritismedicine.diseaseArthritis JuvenilehumanitiesEuropeCross-Sectional StudiesLatin AmericaHealth assessmentPhysical therapyFemalebusinessPsychosocialJuvenile rheumatoid arthritisCohort study
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182 Does emergency physician prehospital management improve outcome of severe blunt trauma?

2010

Severe blunt traumas are a leading cause of premature death and handicap. The benefit for the patient of pre-hospital management by emergency physicians remains under debate because of possible delayed hospital admission. This study aimed at comparing the impact of basic life support (BLS) performed by fire brigades with advanced life support (ALS) performed by SMUR (Service Mobile d9Urgences et de Reanimation) physicians, on 30-day mortality. The FIRST study (French Intensive Care Recorded Severe Trauma) is a French observational multicentric study designed in order to describe the modalities of severe blunt trauma management. The study population was composed of trauma patients over 18 ye…

Gynecologymedicine.medical_specialtyPediatricsbusiness.industryHealth PolicyUniversity hospitalSevere traumaBlunt traumaIntensive careHospital admissionmedicineInjury Severity ScoreMedical assessmentEmergency physicianbusinessBMJ Quality & Safety
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Psoriasis moderada-grave en pacientes pediátricos y jóvenes: experiencia en el registro BIOBADADERM

2022

Resumen {0>El debut de la psoriasis en la edad pediatrica, aunque generalmente leve, puede requerir tratamiento sistemico en las formas moderadas o graves de la enfermedad. Childhood-onset psoriasis generally follows an indolent course but patients with moderate or severe disease may require systemic treatment. El objetivo de este trabajo es analizar la frecuencia relativa, las caracteristicas de los pacientes, el tratamiento empleado y los eventos adversos (EA) observados a partir del registro BIOBADADERM en ninos y jovenes con psoriasis moderada-grave. The aim of this study was to determine the relative proportion of children and young people aged up to 21 years with moderate to severe ps…

Gynecologymedicine.medical_specialtybusiness.industryModerate to severe psoriasisSevere diseaseMean ageGeneral Medicinemedicine.diseaseBIOBADADERMPsoriasis Area and Severity IndexPsoriasisMedicinePsoriasisRegistrosInfanciabusiness
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