Search results for " simple"

The Perception of Causality in Light of Process Ontology

2015

Human perception has an important emotional dimension. Besides having a “presentational” element that dominates the high cognitive activities of human beings, there are certain “densities of feelings,” which are inextricably intertwined with the presentational contents of our perceptual states. This does not mean that human perception is just instinctive, irrational, or intrinsically subjective. The Whiteheadian scheme allows us to determine the nature of the “emotional background” of perception without falling into the traps of subjectivism, representationalism, or substantialism. The feeling which I call “the sense of physicality” is just one of the elements of this emotional dimension in…

Deoxyribonucleases in Herpes simplex Virus Type 1 and 2 Infected Primary Rabbit Kidney Cells

1980

Abstract In primary rabbit kidney cells infected with herpes simplex virus four different neutral deoxyribonuclease activities can be detected by means of the deoxyribonuclease assay in DNA-containing polyacrylamide gels following their separation by discelectrophoresis. The method is suitable to follow independently the change in each activity of the different enzymes using only about 5 × 105 cells for each assay during the time-course of infection. Under these conditions one enzyme activity is constant, two disappear while the activity of a fourth one present only in infected cells, increases.

Inhibition of herpesvirus DNA synthesis by 9-beta-D-arabinofuranosyladenine in cellular and cell-free systems.

1977

9-beta-D-Arabinofuranosyladenine 5'-triphosphate (ara-ATP) is an inhibitor both of DNA polymerase-alpha and -beta from noninfected rabbit kidney cells and of the DNA-dependent DNA polymerase induced by herpes simplex virus Type 1 (strain IES). The studies were performed with partially purified enzymes, and each of the different polymerase preparations contained only one DNA-dependent DNA polymerase species. These enzymes were inhibited in a competitive manner. The HSV-induced DNA-dependent DNA polymerase was 39-fold more sensitive to ara-ATP than was cellular DNA polymerase-beta and 116-fold more sensitive than cellular DNA polymerase-alpha. The affinity of the HSV-induced enzyme for ara-AT…

Phenotypic tradeoffs between egg number and egg size in three parasitic anisakid nematodes

2007

Phenotypic tradeoffs between number and size of eggs were tested in three component populations of three marine anisakid nematodes: Anisakis simplex, Pseudoterranova decipiens and Contracaecum osculatum. Body and uterine volumes (as proxies of female size), and egg number, mean egg volume and clutch volume (as descriptors of reproductive output) were measured in 50 females of each species. Evidence of a phenotypic tradeoff was detected only in A. simplex; the first time that has been found in a parasite population. Comparison of feasible values inferred from the van Noordwijk and de Jong's model and current data showed that interindividual variation in egg size was narrower than expected in…

Nuclear calcium signaling by inositol trisphosphate in GH3 pituitary cells

2008

It has been proposed that nuclear and cytosolic Ca2+ ([Ca2+]N and [Ca2+]C) may be regulated independently. We address here the issue of whether inositol trisphosphate (IP3) can, bypassing changes of [Ca2+]C, produce direct release of Ca2+ into the nucleoplasm. We have used targeted aequorins to selectively measure and compare the changes in [Ca2+]C and [Ca2+]N induced by IP3 in GH3 pituitary cells. Heparin, an IP3 inhibitor that does not permeate the nuclear pores, abolished the [Ca2+]C peaks but inhibited only partly the [Ca2+]N peaks. The permeant inhibitor 2-aminoethoxy-diphenyl-borate (2-APB) blocked both responses. Removal of ATP also inhibited more strongly the [Ca2+]C than [Ca2+]N pe…

Virus-nucleus interactions in late herpesvirus infection

2017

Herpes simplex virus 1 (HSV-1) on alfaherpesviruksiin kuuluva vaipallinen, kaksijuosteista DNA:ta sisältävä virus. Kosketus- ja pisaratartuntana herkästi leviävä HSV-1 on maailmanlaajuisesti huomattava taudinaiheuttaja, sillä virusta kantaa arviolta 67 % väestöstä. Tartunta on elinikäinen. Latentissa vaiheessa HSV-1:n genomi säilyy aistihermojen hermosolmukkeissa. Viruksen aktivoituminen lyyttiseen lisääntymiskiertoon oireilee tyypillisesti rakkuloina kasvojen iholla ja limakalvoilla. HSV-1:n genomin replikoituminen ja uusien viruskapsidien muodostuminen tapahtuvat isäntäsolun tumassa, jossa viruksen rakentumisalue laajenee infektion edetessä. Samalla isäntäsolun kromatiini tiivistyy ja pak…

EXPERIMENTAL INVESTIGATION OF DILUTE SOLID-LIQUID SUSPENSION IN AN UNBAFFLED STIRRED VESSELS BY A NOVEL PULSED LASER BASED IMAGE ANALYSIS TECHNIQUE

2009

The availability of experimental information on solid distribution inside stirred tanks is a topic of great importance in several industrial applications. The measurement of solid particle distribution in turbulent multiphase flow is not simple and the development of suitable measurement techniques is still in progress. In this work a novel non-intrusive technique for measuring particle concentration fields in solid-liquid systems is employed. The technique makes use of a laser sheet, a high sensitivity digital camera for image acquisition and a Matlab procedure for post-processing the acquired images. Experimental data are here obtained for the case of an unbaffled stirred tank. Stable tor…

Latent growth curve model e simplex model: un’applicazione allo studio del programma di intervento aprender a convivir

2014

Herpes Simplex Esophagitis in Immunocompetent Host: A Case Report

2009

Introduction. Herpes simplex esophagitis is well recognized in immunosuppressed subjects, but it is infrequent in immunocompetent patients. We present a case of HSE in a 53-year-old healthy man. Materials and Methods. The patient was admitted with dysphagia, odynophagia, and retrosternal chest pain. An esophagogastroduodenoscopy revealed minute erosive area in distal esophagus and biopsies confirmed esophagitis and findings characteristic of Herpes Simplex Virus infection. Results. The patients was treated with high dose of protonpump inhibitor, sucralfate, and acyclovir, orally, with rapid resolution of symptoms. Discussion. HSV type I is the second most common cause of infectious esophagi…

Herpes simplex virus type 1 and 2 in the adrenal glands: Replication and histopathology

1986

The adrenal glands were shown to be the most severely infected organs in the early phase of HSV-1 infections (up to 10 days p.i.) after i.p. infections in mice. Virus could be isolated from the adrenal glands as early as one hour after infection with pathogenic and apathogenic strains. Infection of the adrenal glands is a result of viremia. The content of HSV-1 (5 strains) was much higher in the adrenals than in spleen and liver. It peaked at 3-4 days p.i. compared to 1-2 days in spleen and liver. Only strain 17 syn+ produced low tissue titres in the adrenal glands. Morphologic alterations by HSV-1 infections commenced with distinct foci 2 days after infection in the zona fasciculata, detec…