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Characterization of DrosophilaHemoglobin
2002
In contrast to previous assumptions, the fruit fly Drosophila melanogaster possesses hemoglobin. This respiratory protein forms a monomer of about 17 kDa that is not exported into the hemolymph. Recombinant Drosophila hemoglobin displays a typical hexacoordinated deoxy spectrum and binds oxygen with an affinity of 0.12 torr. Four different hemoglobin transcripts have been identified, which are generated by two distinct promoters of the hemoglobin (glob1) gene but are identical in their coding regions. Putative binding sites for hypoxia-regulated transcription factors have been identified in the gene. Hemoglobin synthesis in Drosophila is mainly associated with the tracheal system and the fa…
Distribution of biomass and site location of combustion and gasification power plants in western Sicily
2012
The substitution of conventional fossil fuels with biomass for energy production results both in the reduction of greenhouse gases emissions and in the replacement of non-renewable energy sources. The use of biomass for energy production responds to the growing pressure of government policies towards the achievement of better environmental sustainability of power generation processes. This is particularly true for the agricultural areas of Sicily, where the realization of new economic dynamics can lead to development of a local economic system. However, at present, generating energy from biomass is rather expensive due to both technological limits related to low conversion efficiencies, and…
En contexte ou hors contexte : lecture des matériaux et lecture du bâti
2020
Le choix des matériaux occupe une place importante dans l’élaboration du projet architectural, et détermine des orientations essentielles pour le chantier, dans la réalisation de celui-ci, son organisation, voire sa progression. Loin de se résumer à un simple descripteur ou accessoire de la stratigraphie du bâtiment, les matériaux de construction sont avant tout le reflet d’une réalité complexe du chantier à la fois matérielle et immatérielle : projet, exigences et capacité financière du commanditaire, réseaux d’échange, environnement sollicité. Leur prise en compte dans l’analyse du bâti transcende la logique stratigraphique, en épaulant celle-ci là où elle fait défaut et en replaçant la r…
Mestieri e competenze nel cantiere di architettura in Sicilia tra Trecento e primo Cinquecento
2016
La documentazione archivistica ha fornito agli studiosi una solida base di dati per ricostruire il quadro delle professionalità operanti nel cantiere di architettura in Sicilia tra la fine del medioevo e il principio dell’età moderna. Un dato certo è innanzitutto l’esistenza di una organizzazione gerarchica che prevedeva almeno tre livelli. Al vertice della piramide si trova la figura del capomastro chiamato a dirigere l’opera e spesso ad assumere un ruolo di tipo “imprenditoriale”. Impegni e responsabilità sono spesso condivisi con un altro maestro, per ragioni di opportunità e per mantenere la libertà di contrarre più impegni lavorativi in contemporanea. Il livello immediatamente inferior…
Problematic internet use prior to and during the COVID-19 pandemic
2021
The health and socio-economic challenges arising from the COVID-19 pandemic have led to greater reliance on the internet to meet basic needs and responsibilities. Greater engagement in online activities may have negative mental and physical health consequences for some vulnerable individuals, particularly under mandatory self-isolation or ‘lockdown’ conditions. The present study investigated whether changes in levels of involvement in online activities during the COVID-19 pandemic (i.e., watching TV series,online sexual activities, video games, social networks, gambling, online shopping, and instant messaging) were associated with problematic internet use, as well as whether certain psychol…
Immediate 3-dimensional ridge augmentation after extraction of periodontally hopeless tooth using chinblock graft
2015
Background: The aim of the present study was to evaluate clinically and radiographically, the efficacy of immediate ridge augmentation to reconstruct the vertical and horizontal dimensions at extraction sites of periodontally hopeless tooth using an autogenous chin block graft. Material and Methods: A total of 11 patients (7 male & 4 female) with localized advanced bone loss around single rooted teeth having hopeless prognosis and indicated for extraction were selected for the study. The teeth were atraumatically extracted and deficient sites were augmented using autogenous chin block graft. Parameters like clinically soft tissue height - width and also radiographic ridge height -width were…
Stability and marginal bone loss in implants placed using piezoelectric osteotomy versus conventional drilling: systematic review and meta-analysis.
2021
Background The main objective of this systematic review was to compare primary and secondary implant stability between placement with piezoelectric osteotomy and conventional drilling, comparing marginal bone losses as a secondary objective. Material and Methods An electronic search was conducted using PubMed (MEDLINE), Scopus, and Cochrane Library (Wiley) databases, besides a manual search. Results A total of 153 articles were retrieved, 39 from Pubmed, 44 from Scopus, and 70 from the Cochrane Library. After removing duplicates, 112 articles (1 from the manual search) were screened, and 9 were finally selected for qualitative and statistical analyses. Conclusions Piezoelectric surgery is a…
Spatial Memory Drives Foraging Strategies of Wolves, but in Highly Individual Ways
2022
The ability of wild animals to navigate and survive in complex and dynamic environments depends on their ability to store relevant information and place it in a spatial context. Despite the centrality of spatial memory, and given our increasing ability to observe animal movements in the wild, it is perhaps surprising how difficult it is to demonstrate spatial memory empirically. We present a cognitive analysis of movements of several wolves (Canis lupus) in Finland during a summer period of intensive hunting and den-centered pup-rearing. We tracked several wolves in the field by visiting nearly all GPS locations outside the den, allowing us to identify the species, location and timing of ne…
Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents
2021
Three novel pyrazolo-[4,3-e][1,2,4]triazolopyrimidine derivatives (1, 2, and 3) were designed, synthesized, and evaluated for their in vitro biological activity. All three compounds exhibited different levels of cytotoxicity against cervical and breast cancer cell lines. However, compound 1 showed the best antiproliferative activity against all tested tumor cell lines, including HCC1937 and HeLa cells, which express high levels of wild-type epidermal growth factor receptor (EGFR). Western blot analyses demonstrated that compound 1 inhibited the activation of EGFR, protein kinase B (Akt), and extracellular signal-regulated kinase (Erk)1/2 in breast and cervical cancer cells at concentrations…
Sequential Reactions of Alkynes on an Iridium(III) Single Site
2017
Sequential insertion of terminal alkynes on IrIII cyclometalated complexes allow the formation of novel metallapolycycles in a controlled and efficient manner. ortho-Methylarylethynyl derivatives led to an unprecedented cascade combination of three fundamental processes (C−C bond formation, C(sp3)−H activation, and reductive coupling) on a single IrIII center, in a process compatible with functionalized biomolecules and photoactive substrates. The reaction with tert-butylacetylene led to a [6,5,4]-polycycle that incorporates an iridacyclobutenylidene in its structure. The sequence is a multicomponent reaction in which the metal not only promotes the different steps but also determines their…