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L’incompletezza del patrimonio architettonico: testimonianze in terra cruda a Solunto
2015
L'incompletezza riassume la maggior parte delle caratteristiche fisiche e immateriali del patrimonio architettonico e produce due conseguenze principali: la sua elevata vulnerabilità e le difficoltà di comprensione. Questo tema offre anche una parola chiave per capire alcune situazioni critiche nei processi di conoscenza, conservazione e valorizzazione sul patrimonio architettonico. Le testimonianze di terra cruda superstiti a Solunto non sono tanto rilevanti per quantità e dimensione, ma forniscono un esempio lampante di questo tema. L’obiettivo di conservare questi pochi lacerti soluntini di architettura in crudo può assumere un maggior senso, se esso si collega, da un lato, alle potenzia…
Prime evidenze degli effetti delle nuove coperture sul microclima della Villa romana del Casale
2012
In September 2011 has started a new in situ microclimatic monitoring to detect the environmental conditions created by the new covering system of the Villa del Casale di Piazza Armerina (Sicily). The investigation regards sample room, on which the new covering system has been completed, and rooms that still are covered by the methacrylate old system, realized in the 60s, and so many times modified in the following decades. The comparison between the environmental parameters related to the existing covering system that, such as is demonstrated by the previous survey, causes undesired effect both for fruition and for conservation, and the data related to the new covering system, allow to veri…
La fase del Ibérico final en el asentamiento del Torrelló del Boverot (Almazora, Castellón): dos piezas cerámicas singulares
2000
Since the end of 1988, when excavation was resumed at the Torrelló del Boverot site in Almazora (Castellón), large amounts of material —mostly ceramics— have been recovered, dating from the end of the Iberian period, which, chronologically, marked the end of the village's life. This paper discusses two unusual ceramic pieces from this late period, documented during the excavations that took place in 1995, undertaken in the central area of the site. The records obtained in this work matches that of a batch of materials donated to the Museum of Almazora by the amateurs who excavated this village in the mid-1970s.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
2020
The effect of the polyanionic polymer of inorganic polyphosphate (polyP) involved in innate immunity on the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the cellular ACE2 receptor was studied. The RBD surface comprises a basic amino acid stretch of four arginine residues which interact with the physiological polyP (polyP40) and polyP3. Subsequently, the interaction of RBD with ACE2 is sensitively inhibited. After the chemical modification of arginine, an increased inhibition by polyP, at a 1 : 1 molar ratio (polyP : RBP), is measured already at 0.1 μg mL−1. Heparin was ineffective. The results suggest a potential therapeutic benefit of polyP against SARS-C…
Arginine-rich peptides are blockers of VR-1 channels with analgesic activity
2000
Vanilloid receptors (VRs) play a fundamental role in the transduction of peripheral tissue injury and/or inflammation responses. Molecules that antagonize VR channel activity may act as selective and potent analgesics. We report that synthetic arginine-rich hexapeptides block heterologously expressed VR-1 channels with submicromolar efficacy in a weak voltage-dependent manner, consistent with a binding site located near/at the entryway of the aqueous pore. Dynorphins, natural arginine-rich peptides, also blocked VR-1 activity with micromolar affinity. Notably, synthetic and natural arginine-rich peptides attenuated the ocular irritation produced by topical capsaicin application onto the eye…
Integrating genomic binding site predictions using real-valued meta classifiers
2008
Currently the best algorithms for predicting transcription factor binding sites in DNA sequences are severely limited in accuracy. There is good reason to believe that predictions from different classes of algorithms could be used in conjunction to improve the quality of predictions. In this paper, we apply single layer networks, rules sets, support vector machines and the Adaboost algorithm to predictions from 12 key real valued algorithms. Furthermore, we use a ‘window’ of consecutive results as the input vector in order to contextualise the neighbouring results. We improve the classification result with the aid of under- and over-sampling techniques. We find that support vector machines …
2016
Abstract. Through measurements of NO2, O3 and NO3 during the PARADE campaign (PArticles and RAdicals, Diel observations of mEchanisms of oxidation) in the German Taunus mountains we derive nighttime steady-state lifetimes (τss) of NO3 and N2O5. During some nights, high NO3 (∼ 200 pptv) and N2O5 (∼ 1 ppbv) mixing ratios were associated with values of τss that exceeded 1 h for NO3 and 3 h for N2O5 near the ground. Such long boundary-layer lifetimes for NO3 and N2O5 are usually only encountered in very clean/unreactive air masses, whereas the PARADE measurement site is impacted by both biogenic emissions from the surrounding forest and anthropogenic emissions from the nearby urbanised/industri…
Evaluation of Surface Temperature and Emissivity Derived from ASTER Data: A Case Study Using Ground-Based Measurements at a Volcanic Site
2010
Abstract The land surface temperature (LST) and emissivity (LSE) derived from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data were evaluated in a low spectral contrast volcanic site at an altitude of 2000 m on the island of Tenerife, Spain. The test site is almost flat, thermally homogeneous, and without vegetation cover or variation in its surface composition. ASTER data correspond to six scenes, under both day- and nighttime conditions during 2008. This case study analyzes the impacts of the sources of inaccuracies using the temperature–emissivity separation (TES) algorithm. Uncertainties associated with inaccurate atmospheric correction were minimized by means…
Deconvolution procedure of the UV-vis spectra. A powerful tool for the estimation of the binding of a model drug to specific solubilisation loci of b…
2015
UV-vis-spectra evolution of Nile Red loaded into Tween 20 micelles with pH and [Tween 20] have been analysed in a non-conventional manner by exploiting the deconvolution method. The number of buried sub-bands has been found to depend on both pH and bio-surfactant concentration, whose positions have been associated to Nile Red confined in aqueous solution and in the three micellar solubilisation sites. For the first time, by using an extended classical two-pseudo-phases-model, the robust treatment of the spectrophotometric data allows the estimation of Nile Red binding constant to the available loci. Hosting capability towards Nile Red is exalted by the pH enhancement. Comparison between bin…