Search results for " tecniche"
showing 10 items of 317 documents
Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities
2020
Although improvement in early diagnosis and treatment ameliorated life expectancy of cancer patients, metastatic disease still lacks effective therapeutic approaches. Resistance to anticancer therapies stems from the refractoriness of a subpopulation of cancer cells—termed cancer stem cells (CSCs)—which is endowed with tumor initiation and metastasis formation potential. CSCs are heterogeneous and diverge by phenotypic, functional and metabolic perspectives. Intrinsic as well as extrinsic stimuli dictated by the tumor microenvironment (TME)have critical roles in determining cell metabolic reprogramming from glycolytic toward an oxidative phenotype and vice versa, allowing cancer cells to th…
Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells
2022
Despite advances in the curative approach, the survival rate of advanced colorectal cancer (CRC) patients is still poor, which is likely due to the emergence of cancer cell clones resistant to the available therapeutic options. We have already shown that CD44v6-positive CRC stem cells (CR-CSCs) are refractory toward standard anti-tumor therapeutic agents due to the activation of the PI3K pathway together with high HER2 expression levels. Tumor microenvironmental cytokines confer resistance to CR-CSCs against HER2/PI3K targeting by enhancing activation of the MAPK pathway. Here, we show that the CSC compartment, spared by BRAF inhibitor-based targeted therapy, is associated with increased ex…
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
2022
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce drug development periods and costs. Epidemiological and preclinical evidence support the antitumor activity of antipsychotic drugs. Herein, we dissect the mechanism of action of the typical antipsychotic spiperone in CRC. Spiperone can reduce the clonogenic potential of stem-like CRC cells (CRC-SCs) and induce cell cycle arrest and apoptosis, in both differentiated and CRC-SCs, at clinically relevant co…
Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
2022
The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.
Le chiese basiliane della Sicilia orientale
2008
La cibernetica e il ’68.
2010
Recensione a: M. Melot, Libro, fotografie di Nicolas Taffin, Edizioni Sylvestre Bonnard
2007
Effetto della dimensione dell'anello sulla conducibilità idraulica del suolo saturo misurata con la tecnica SFH
2009
Nel lavoro è stata esaminata la relazione tra la conducibilità idraulica del suolo saturo, Kfs, misurata in campo con la tecnica Simplified Falling Head (SFH) e la dimensione della superficie campionata con una singola prova. L’indagine è stata condotta in un suolo franco-sabbioso ed in uno franco-limoso, esplorando la medesima superficie complessiva (0.71 m2) con anelli di diametro compreso tra 0.15 e 0.30 m. Nel suolo franco-sabbioso, le misure di Kfs effettuate con gli anelli piccoli sono risultate significativamente più elevate di quelle ricavate con gli anelli grandi. In particolare, i valori medi hanno mostrato una discrepanza di un fattore 1.7 e il ricorso agli anelli piccoli ha dete…
Tecnologie e materiali innovativi per il restauro strutturale di edifici in c.a. di interesse storico – il teatro Finocchiaro a Palermo
2007
La premessa fondamentale per la redazione di un progetto di restauro è la conoscenza del fabbricato, oggetto di intervento, delle sue evoluzioni nel tempo, dei materiali e delle tecnologie impiegate durante la sua realizzazione. Soltanto l’approfondimento di questa fase preliminare salvaguarda il progettista dal commettere errori e valutazioni sbagliate circa i materiali e le tecnologie da impiegare nel rapporto di compatibilità con l’esistente che si va a modificare, spesso integrare, comunque alterare. Per il teatro Finocchiaro a Palermo si è resa necessaria un’attenta e minuziosa indagine preliminare, culminata nel rilievo geometrico della fabbrica, con particolare attenzione alla valuta…