Search results for " tg"

showing 10 items of 56 documents

Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells

2004

The objective of our study was to determine the regulatory effects that endogenous transforming growth factor beta (TGFbeta) exerts on T cells in the pathogenesis of collagen-induced arthritis (CIA). CIA was induced in transgenic mice expressing a dominant negative TGFbeta type II receptor in T cells under the control of the human CD2 promoter. Clinical and histological arthritis scores were determined and experiments on disease induction and the healing phase of disease were performed. The proliferation and cytokine production of draining lymph node cells in vitro were analyzed. Transgenic mice were more susceptible to induction of CIA. The overall incidence was higher in transgenic mice t…

T-LymphocytesMice Inbred StrainsMice Transgenictransgenic miceTh1 CellsArthritis ExperimentalSeverity of Illness Indexdominant negative TGFβ type II receptorArthritis RheumatoidMiceMice Inbred DBATransforming Growth Factor betaAnimalsCytokinesCattleDisease SusceptibilityLymph NodesCollagen Type IICells CulturedCrosses GeneticResearch ArticleIFNγCell ProliferationArthritis Research & Therapy
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Cytokine Polymorphism in Takotsubo Cardiomyopathy

2014

IMIN11. Cytokine Polymorphism in Takotsubo Cardiomyopathy P. Di Gangi1, L. Scola1, S. Giambanco1, M. Bova1, G. Santini1, L. Vaccarino1, C. R. Balistreri1, D. Lio1, P. Assennato1, S. Novo1, G. Novo1 1University of Palermo, Palermo, Italy Background: Takotsubo (TT) cardiomyopathy is characterised by an acute left ventricular dysfunction triggered by emotional or physical stresses. Clinically, the syndrome is characterised by acute symptoms mimicking acute infarction without relevant electrocardiographic and biochemical markers of myocardial damage changes. Stressful events inducing an excess catecholamine release and myocardial β-adrenergic receptors (β-AR) seem to play a major role in TT. Ac…

Takotsubo (TT) cardiomyopathy ADRB-1 (rs1801253) IL–1A (rs1800587) IL-1B (rs16944) (rs1143634) IL-6 (rs1800795) TNF-α(rs1800629) TGF- β(rs1800471) IL-10 (rs1800872) (rs1800871) (rs1800896) MAL (rs8177374) and TLR-4 polymorphisms
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Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids

2014

The increasing interest in Graphene oxide (GO) is due to many issues: the presence of both sp2-conjugated atoms and oxygen-containing functional groups provides a strong hydrophilicity and the possibility to further functionalize it with other molecules (i.e. π-π interactions covalent attachment etc.) [1]. Furthermore since the GO is biocompatible and noncytotoxic many studies have been recently focused on the development of GO-based nanodevices for bioimaging DNA detection drug delivery. Due to their low cytotoxicity and large internal surface area silica nanoparticles have been taken into account as promising material for biolabeling and drug loading/delivery. Particular consideration has recently been demonstrated for GO-silica composites because of the potentialities for electrical applications their chemical inertia and stability toward ions exposure. The possibility to combine the extraordinary properties of GO and silica offers several advantages for the realization of nanoprobes for biological applications and of biosensor [12]. The strategy for the fabrication of GO-nanosilica nanohybrids can be schematized as follows: (i) synthesis of GO by oxidizing graphite powder with the method described by Marcano et al. [3] (ii) Preparation of oxygen-loaded silica nanoparticles by thermal treatments in controlled atmosphere in order to induce high NIR emission at 1272 nm from high purity silica nanoparticles. (iii) preparation of GrO-silica nanohybrid films via rapid solvent casting in water. The nanohybrids were tested by XPS FTIR Raman analysis UV photoluminescence analysis TGA Zeta potential measurements electrical tests AFM and SEM. Several nanohybrids were prepared by combining two different typologies of GO and two different samples of silica.
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Thermogravimetric analysis. A tool to evaluate the ability of mixtures in consolidating waterlogged archaeological woods

2010

Waterlogged archaeological woods (Pinus pinaster, Ulmus cf. minor and Fagus sylvatica L.) were consolidated by using Colophony, Rosin 100, and a mixture of Poly(ethylene) glycol (PEG) 3000 and Poly(propylene) glycol (PPG) 425. The efficiency of the consolidants was estimated by determining the content entrapped into the cavity of degraded wood. For this purpose, thermogravimetry was demonstrated to be a reliable tool. In the case that the polymeric mixture was used for impregnation, it was also possible to discriminate the amount of PEG 3000 from that of PPG 425 captured by the wood capillaries. Regardless of the wood nature, all the consolidants were present in treated samples in large amo…

Thermogravimetric analysisEthyleneMaterials scienceAbsorption of waterbiologyRosinCondensed Matter Physicsbiology.organism_classificationArchaeologywood TGA polymerThermogravimetrychemistry.chemical_compoundFagus sylvaticachemistryPEG ratiomedicinePhysical and Theoretical ChemistryThermal analysismedicine.drug
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Thermo-oxidative ageing of an organo-modified clay and effects on the properties of PA6 based nanocomposites

2013

a b s t r a c t In this work a careful investigation on the degradation of an organically modified montmorillonite sample (Cloisite 15A) thermal treated under different atmospheres, namely nitrogen, air and oxygen enriched atmosphere was performed. The exposure time of the thermal treatment ranged between 5 and 300 min. The chemical composition evolution as function of the thermal treatment conditions of the clay organic modifier was monitored by means of combined thermogravimetry/Fourier transform infrared spectroscopy (TGA-FTIR). Moreover, the morphological behaviour of treated Cloisite 15A sam- ples as function of the time and of the decomposition atmosphere was investigated by X-ray dif…

Thermogravimetric analysisMaterials scienceNanocompositeMontmorillonite Organic modifier Degradation Nanocomposites TGA–FTIRThermal treatmentCondensed Matter PhysicsThermogravimetrychemistry.chemical_compoundMontmorillonitechemistryLimiting oxygen concentrationPhysical and Theoretical ChemistryFourier transform infrared spectroscopyComposite materialThermal analysisInstrumentation
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Structural Characterisation of Complex Layered Double Hydroxides and TGA-GC-MS Study on Thermal Response and Carbonate Contamination in Nitrate- and …

2015

Layered double hydroxides (LDHs) are versatile materials used for intercalating bioactive molecules in the fields of pharmaceuticals, nutraceuticals and cosmetics, with the purpose of protecting them from degradation, enhancing their water solubility to increase bioavailability and improving their pharmacokinetic properties and formulation stability. Moreover, LDHs are used in various technological applications to improve stability and processability. The crystal chemistry of hydrotalcite-like compounds was investigated by X-ray powder diffraction (XRPD), automated electron diffraction tomography (ADT) and thermogravimetric analysis (TGA)-GC-MS to shed light on the mechanisms involved in io…

Thermogravimetric analysishydrotalcytethermal responseInorganic chemistryIntercalation (chemistry)intercationsion exchangeengineering.materialCatalysischemistry.chemical_compoundCrystallinityAdsorptionlayered compoundsOrganic chemistryTGAHydrotalciteIon exchangeChemistryOrganic Chemistryelectron diffraction; intercations; ion exchange; layered compounds; structure elucidationstructure elucidationLayered double hydroxidesstructural characterization hydrotalcyte TGA GC-MS thermal response X-ray powderGeneral ChemistryX-ray powderstructural characterizationengineeringCarbonateelectron diffractionGC-MS
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Low hrTSH-Tg levels in patients affected by papillary thyroid microcarcinoma are influenced by pre-surgery L-thyroxine therapy.

2006

Tireoglobulin tg papillary carcinoma thyroidSettore MED/13 - Endocrinologia
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Differences of stabilized organic carbon fractions and microbiological activity along Mediterranean Vertisols and Alfisols profiles

2010

This study examined the chemical and structural properties of humic substances and microbiological activity in order to verify differences in carbon dynamics along soil profiles in two Vertisols (Typic Haploxerert and Xeric Epiaquert) and two Alfisols (Mollic Haploxeralf and Ultic Haploxeralf) developed under Mediterranean climate in Italy. Humification parameters, thermal methods, including differential scanning calorimetry (DSC) and thermogravimetry (TG), together with Fourier transform infrared (FT-IR) and fluorescence spectroscopies were used to characterize humic acids (HA). Microbiological activity of soils was assessed by basal respiration, metabolic quotient (qCO2) and Cmic:Corg rat…

Total organic carbonChemistrySoil ScienceMineralogyVertisolHumusThermogravimetrySettore AGR/14 - PedologiaSoil pHEnvironmental chemistrySoil waterAlfisolSoil horizonVertisols Alfisols Microbial indices DSC TG FT-IR Fluorescence spectra Humic acidsGeoderma
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TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

2007

The epithelial-to-mesenchymal transition (EMT) is a crucial process, occurring both during development and tumor progression, by which an epithelial cell undergoes a conversion to a mesenchymal phenotype, dissociates from initial contacts and migrates to secondary sites. We recently reported that in hepatocytes the multifunctional cytokine TGFβ induces a full EMT characterized by (i) Snail induction, (ii) E-cadherin delocalization and down-regulation, (iii) down-regulation of the hepatocyte transcriptional factor HNF4α and (iv) up-regulation of mesenchymal and invasiveness markers. In particular, we showed that Snail directly causes the transcriptional down-regulation of E-cadherin and HN…

Transcriptional ActivationTGFβFAK; MT; Src; TGFβ; Animals; Biomarkers Tumor; Cadherins; Cell Line; Cell Transformation Neoplastic; Enzyme Activation; Epithelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Hepatocytes; Liver Neoplasms; Mesoderm; Mice; Neoplasm Invasiveness; Signal Transduction; Transcriptional Activation; Transforming Growth Factor beta; Up-Regulation; src-Family Kinases; Cell BiologyCell LineMesodermFocal adhesionMiceTransforming Growth Factor betaBiomarkers TumorAnimalsHepatocyteNeoplasm InvasivenessNeoplasm InvasiveneEpithelial CellFocal Adhesion Protein-Tyrosine KinaseFAKbiologyAnimalCadherinLiver NeoplasmsMesenchymal stem cellEpithelial CellsCell BiologyTransforming growth factor betaTgf beta; fak; srcCadherinsUp-RegulationCell biologyEnzyme ActivationCell Transformation Neoplasticsrc-Family KinasesHepatocyte nuclear factor 4Liver NeoplasmTumor progressionMTFocal Adhesion Protein-Tyrosine KinasesCadherinHepatocytesCancer researchbiology.proteinsrc-Family KinaseSignal transductionSrcSignal TransductionProto-oncogene tyrosine-protein kinase SrcExperimental Cell Research
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Kriptovalūtu volatilitātes modelēšana un prognozēšana

2018

Maģistra darbā ir veikta GARCH volatilitātes modelēšana četrām, pēc tirgus kapitalizācijas, lielākajām kriptovalūtām: Bitcoin, Ethereum, Litecoin un Ripple. Darba empīriskajā daļā, tiek veikta kriptovalūtu GARCH, TGARCH, EGARCH un PGARCH modelēšana un prognozēšana izmantojot normālo un stjūdenta t sadalījumus, aplūkojot laika periodu no 07.08.2015 līdz 27.03.2018. Labākais modelis tiek noteikts salīdzinot trīs modeļu informācijas kritērijus un modeļu prognozes novērtējumus. Kaut arī stjūdenta t sadalījuma izmantošana uzlaboja modeļu novērtējumu visām četrām kriptovalūtām, tomēr tas ne vienmēr uzlaboja modeļa prognozi. Pēc iegūtajiem rezultātiem var secināt Ripple un Bitcoin EGARCH modeļi pā…

Volatilitātes modelēšana un prognozēšanaKriptovalūtaBitcoin Litecoin Ethereum RippleGARCH TGARCH EGARCH PGARCHEkonomika
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