Search results for " tolerance"
showing 10 items of 760 documents
Regulatory (suppressor) T cells in peripheral allograft tolerance and graft-versus-host reaction.
2004
Among the mechanisms capable of inducing peripheral tolerance, regulatory (suppressor) T cells (Treg) probably play a key role in the control of both reactivity to self-antigens and alloimmune response. Augmentation or manipulation of Treg could improve organ allograft survival or control graft-versus-host disease, thus resulting in operational tolerance. The role of this immunomanipulation as one method of inducing tolerance has yet to be clearly defined.
Immune regulation by regulatory T cells: implications for transplantation.
2003
Item does not contain fulltext The induction of antigen-specific T cell tolerance and its maintenance in the periphery are critical for the immune system to prevent autoaggressive immune responses. Our current state of knowledge about the immunoregulatory mechanisms responsible for T cell tolerance in the periphery offers new possibilities for immunomodulation to prevent transplant rejection as well as to diminish autoimmune reaction or chronic allergy. There is growing evidence that dendritic cells, besides their well-known T cell stimulatory functions, also maintain and regulate T cell tolerance in the periphery. This control function is exerted by certain maturation stages and subsets of…
Different strategies to achieve Pb-tolerance by the two Trebouxia algae coexisting in the lichen Ramalina farinacea.
2012
Lichen thalli are permeable to airborne substances, including heavy metals, which are harmful to cell metabolism. Ramalina farinacea shows a moderate tolerance to Pb. This lichen comprises two Trebouxia phycobionts, provisionally referred to as TR1 and TR9, with distinct physiological responses to acute oxidative stress. Thus, there is a more severe decay in photosynthesis and photosynthetic pigments in TR1 than in TR9. Similarly, under oxidative stress, antioxidant enzymes and HSP70 protein decrease in TR1 but increase in TR9. Since Pb toxicity is associated with increased ROS formation, we hypothesized greater Pb tolerance in this phycobiont. Accordingly, the aim of the present study was …
Are long-haul truck drivers unusually alert? A comparison with long-haul airline pilots.
2020
Abstract Background Recent studies suggest heavy vehicle drivers self-estimate their sleepiness unexpectedly low during night duties. The present study compared sleepiness ratings of long-haul truck drivers with those of long-haul airline pilots during night and non-night duties. In addition, the correspondence between self-rated manifest and predicted latent sleepiness was examined in the two groups. Methods Twenty-two drivers and 33 pilots participated. Their working hours, sleep, on-duty sleepiness, and use of sleepiness countermeasures were measured in naturalistic conditions. Predictions of latent sleepiness were based on the measurements of working hours and sleep using the Sleep/Wake…
Accumulation of sleep loss among shift-working truck drivers.
2021
Sleep loss is known to contribute to road traffic accidents. Professional drivers are vulnerable to curtailment of sleep due to long driving bouts and shift work. To fill in the gap in the literature related to the buildup of sleep loss in irregular shift systems, we recorded the sleep and working hours of 47 shift-working long-haul truck drivers during a two-week period. Sleep (time in bed) was verified by actigraphy and sleep logs. Sleepiness was measured using the Karolinska Sleepiness Scale (KSS). Individual sleep need was based on self-assessments. We examined the accumulated sleep versus self-reported sleep need across the study period, using midnights as points of observation, and th…
Secure, dependable and publicly verifiable distributed data storage in unattended wireless sensor networks
2010
Published version of an article from the journal : Science in China, Series F: Information Sciences. The original publication is available at Spingerlink. http://dx.doi.org/10.1007/s11432-010-0096-7 In unattended wireless sensor networks (UWSNs), sensed data are stored locally or at designated nodes and further accessed by authorized collectors on demand. This paradigm is motivated by certain scenarios where historical or digest data (e.g., average temperature in a day), instead of real-time data, are of interest. The data are not instantly forwarded to a central sink upon sensing, thereby saving communication energy for transmission. Such a paradigm can also improve data survivability by m…
Active-passive control strategy for adjacent buildings
2011
Author's version of a chapter in the book: 2011 Proceedings of the American Control Conference. Also available from the publisher at: http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=05991059 In this paper, a control strategy to mitigate the vibrational response of adjacent buildings under seismic excitation is presented. The proposed strategy combines inter-building passive actuators with active actuators placed in the building stories. The main ideas are presented by means of a simplified two-building model; however, a semi-decentralized overlapping approach via the inclusion principle has been used to impose a proper information exchange structure suitable for wireless control of larg…
Riska tolerances dzimumu un paaudžu atšķirības ieguldījumu produktu iegādē
2021
Šajā pētījumā autore izvērtē riska tolerances saikni ar tādiem faktoriem kā dzimums, vecums un finanšu kompetences, veicot respondentu aptauju 2021.gada aprīlī Latvijā un Igaunijā. Pētījumā tiek izmantota I.Wahl un E.Kircher 2020.gada pētījuma metodoloģiju, apskatot četras riska tolerances kategorijas un to atšķirības, pieņemot lēmumus par ieguldījumu produktu iegādi. Pirmkārt, pētījums atklāj, ka pastāv būtiskas dzimumu atšķirības riska tolerancē, kur vīrieši visās četrās riska tolerances kategorijās uzrāda lielāku risku noturību salīdzinājumā ar sievietēm. Otrkārt, pētījuma dati liecina par to, ka pastāv negatīva saikne starp vecumu un riska noturību. Treškārt, finanšu izglītībai, bet vēl…
Reactive oxygen species activation of MAPK pathway results in VEGF upregulation as an undesired irradiation response
2013
Background Radioresistance limits the effectiveness of radiotherapy in head and neck squamous cell carcinoma. We previously demonstrated post-radiogenic mitogen-activated protein kinase (MAPK) pathway activation and vascular endothelial growth factor (VEGF) release resulting in reduced tumor cell response. Here, we examined the association of this mechanism with the induction of reactive oxygen species (ROS) under irradiation (IR). Methods Intracellular ROS after IR were measured. We modeled radiation-induced ROS by exposure of two SCC lines to H2O2 and evaluated the impact of irradiation and ROS on ERK phosphorylation by Western blot, immunohistochemistry, and ELISA. Results We found eleva…
A VLSI for deskewing and fault tolerance in LVDS links
2005
The device presented at this work is a switch implemented in a 0.35 mum CMOS process for compensating the skew which affects parallel data signal transmissions and for providing fault tolerance in large scale scalable systems, for instance used in trigger farms for high energy physics experiments. The SWIFT chip (SWItch for Fault Tolerance) is part of a cluster built around commercially components which has been inspired by the LHCb experiment. The skew is extremely important because it directly affects the sample window available to the receiver logic and either forces to use quality and expensive cables in order to minimize its effects or reduces the maximum signal transmission range or d…