Search results for " topical"
showing 10 items of 97 documents
Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System.
2018
[EN] In this work, 6-phosphogluconic trisodium salt (6-PG(-)Na(+)) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan cross-linked with 6-PG(-)Na(+). This formulation is obtained by ionic interaction of cationic groups of polymer with anionic groups of the cross linker. These hydrogels are nontoxic, do not cause dermal irritation, are easy to extend, and have an adequate adhesion force to be applied as polymeric film over the skin. This AWN formulation exhibits a first order release kinetic and can be applied as drug vehicle for topical administration or as wound dressing for wound healing…
Comparison of two partial least squares infrared spectrometric methods for the quality control of pediculosis lotions.
2006
Two vibrational spectroscopy procedures have been developed and compared for the direct and simultaneous determination of piperonyl butoxide and tetramethrin, the active ingredients of alcoholic capillary lotions, for hair pediculosis diseases. Nine lotions, purchased from the Spanish market, were analyzed using both, attenuated total reflectance (ATR) and transmission FT-IR measurements, and based on the use of partial least squares (PLS) multivariate calibration. A reduced set of 15 matched standards (11 for calibration and 4 for validation) was employed using both measurement modes. The spectral wave number ranges between 1757 and 1712 cm(-1) was selected to determine tetramethrin by bot…
Polyaspartamide-polylactide electrospun scaffolds for potential topical release of Ibuprofen.
2012
In this work, the production and characterization of electrospun scaffolds of the copolymer α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-graft-polylactic acid (PHEA-g-PLA), proposed for a potential topical release of Ibuprofen (IBU), are reported. The drug has been chemically linked to PHEA-g-PLA and/or physically mixed to the copolymer before electrospinning. Degradation studies have been performed as a function of time in Dulbecco phosphate buffer solution pH 7.4, for both unloaded and drug-loaded scaffolds. By using an appropriate ratio between drug physically blended to the copolymer and drug-copolymer conjugate, a useful control of its release can be obtained. MTS assay on human dermal fi…
Lack of antiandrogenic effects of topical bifonazole on sebaceous glands and hairs in the hamster flank organ.
1993
The activity of topically applied bifonazole was evaluated in vivo in the three androgen-dependent structures of the hamster flank organ, i.e. the pigmented spot, sebaceous glands and hairs. Topical bifonazole in our experience did not demonstrate any morphological effect on sebaceous gland and hair even when applied in the dosage of 3 mg/cm<sup>2</sup>/day. On the basis of our morphometric results we can conclude that topically applied bifonazole does not interfere with cutaneous androgen metabolic transformations in the pilosebaceous unit of the flank organ.
Topical canrenoic acid. Quantification of the antiandrogenic activity in the hamster flank organ
1991
: The topical antiandrogenic activity of potassium canrenoate (CAK), compared with that of spironolactone (SP), was assayed in vivo in female golden Syrian hamsters whose flank organs were stimulated by subcutaneous administration of testosterone propionate. Sebaceous glands and hair were measured by a computerized image analyzer. Pigmented spots, sebaceous gland areas, and the diameter of hairs of the treated flank organs were smaller in the groups that received CAK (1·6 mg/day) and SP (0·4 mg/day). The authors' results showed that CAK may act as a topical antiandrogen on the hamster flank organ when applied in concentrations four times greater than the minimal active dosage of SP. Potassi…
Effects of essential oils of Origanum vulgare L. (Fam. Labiatee), Pelargonium odoratissimum L. (Fam. Geraniaceae) and Syzygium aromaticum L. (Fam. Mi…
2021
The cotton aphid, Aphis gossypii Glover (Homoptera: Aphidiidae), is a cosmopolitan and highly polyphagous species causing serious economic damage to numerous plants including Cucurbitaceae. The use of synthetic insecticides represent the main method of control of this aphid, often resulting in resistance to all the major insecticide group. The use of natural products, such as essential oils (EOs), has increased in recent years because they have advantages in reduction of this resistance. Within this research area, we have implement and evaluate the applications of EOs that aim at reinforcing knowledge on the control of this aphid. We investigated the topical application of the EOs of Origan…
Update on the Management of Pediatric Psoriasis: An Italian Consensus
2022
Introduction Psoriasis affects children with a considerable burden in early life. Treating pediatric psoriasis is challenging also because of the lack of updated specific guidelines. With the recent approval of several biologics for pediatric psoriasis and the ongoing COVID-19 pandemic, the management of young psoriatic patients is facing major changes. A revision of treatment recommendations is therefore needed. Methods In September 2021, a board of six Italian dermatologists convened to update treatment recommendations. The board issued evidence- and consensus-based statements covering relevant areas of pediatric psoriasis, namely: assessment of psoriasis severity, management of children …
Come si gioca ai gochi linguistici?
2014
This paper aims to rethink some features of Wittgenstein’s thought, examining in particular the notion of “language-game.” A discussion of this notion is a way of rethinking the role played by context in linguistic processes. It is a role that cannot be understood if we do not focus on the topic for which the “language game” is played. In particular some characteristics of “language game” will be examined: topicality, broader normativity and multimodality. These characteristics will be applied to some actual “language games” like the standingman of Istanbul.
Language Game: calculus or Pragmatic act?
2013
The authors have tried to make the potentiality inherent in the concept of the linguistic game evident by taking it back to its original context in the work of Wittgenstein. This paper aims to re-examine some features of Wittgenstein’s thought, considering in particular the notion of ‘language-game’. The authors believe that the language-game might play a role in overcoming once and for all the classic distinction between semantics and pragmatics. We deal with the exegetical discussion of the notion ‘language-game’ as it was interpreted in two different senses: as a synonym of calculus or as a minimal unit of linguistic activity that is directed to obtaining certain pragmatic effects in a s…
Protein materials as sustainable non- and minimally invasive strategies for biomedical applications
2022
Protein-based materials have found applications in a wide range of biomedical fields because of their biocompatibility, biodegradability and great versatility. Materials of different physical forms including particles, hydrogels, films, fibers and microneedles have been fabricated e.g. as carriers for drug delivery, factors to promote wound healing and as structural support for the generation of new tissue. This review aims at providing an overview of the current scientific knowledge on protein-based materials, and selected preclinical and clinical studies will be reviewed in depth as examples of the latest progress within the field of protein-based materials, specifically focusing on non- …