Search results for " traffic"
showing 10 items of 384 documents
Biodistribution, Uptake and Effects Caused by Cancer-derived Extracellular Vesicles
2015
Extracellular vesicles (EVs) have recently emerged as important mediators of intercellular communication. They are released in the extracellular space by a variety of normal and cancerous cell types and have been found in all human body fluids. Cancer-derived EVs have been shown to carry lipids, proteins, mRNAs, non-coding and structural RNAs and even extra-chromosomal DNA, which can be taken up by recipient cells and trigger diverse physiological and pathological responses. An increasing body of evidence suggests that cancer-derived EVs mediate paracrine signalling between cancer cells. This leads to the increased invasiveness, proliferation rate and chemoresistance, as well as the acquisi…
Efectos de la exposición crónica al etanol sobre el tráfico intracelular y citoesqueleto como factores implicados en la migración neuronal
2013
El consumo de etanol durante la gestación puede inducir una serie de alteraciones graves en el desarrollo del feto, la manifestación más extrema da lugar al Síndrome Alcohólico Fetal (SAF). La exposición prenatal al alcohol es la causa conocida y, además evitable, más importante de retraso mental en el mundo occidental. Además de déficits cognitivos, los niños con SAF presentan múltiples anomalías estructurales en el sistema nervioso central, como reducción de la masa cerebral, y a nivel celular, daños en la migración neuronal, en el proceso de formación de espinas dendríticas y establecimiento de sinapsis. En la actualidad, los mecanismos moleculares implicados en la teratogénesis inducida…
A fatal iatrogenic right vertebral injury after transoral odontoidectomy and posterior cervical stabilization for a type II odontoid fracture.
2014
Abstract The authors present a singular case of an iatrogenic right vertebral artery injury, involving a 67 year-old man, who reported a type II odontoid fracture (Anderson and D'Alonzo Classification) and posterior atlantoaxial dislocation following a road traffic accident. A small injury involving the right vertebral artery occurred as a consequence of transoral odontoidectomy and posterior cervical stabilization. It was caused by bone spicules of spinal origin and their presence was confirmed by the histological section of the right vertebral artery at the level of C1–C2. The case confirms how iatrogenic vertebral artery injuries during cervical spine surgery may be potentially lethal, e…
Il ruolo dell'organizzazione criminale nel contrasto al traffico illecito di tabacchi lavorati esteri
2019
the paper intends to analyze the features of the Italian criminal law on cigarette smuggling. The domestic system faces the illicit tobacco trade in a very peculiar way, especially if compared with the criminal law of other European countries (e.g. Germany, Greece, Portugal and Spain). The Italian strict regulation (artt. 291 bis, ter, quarter T.U.D.) could appear also unreasonable if set side by side with the domestic legislation on smuggling of goods. Indeed, the latter is characterized by a large use of administrative sanctions instead of the severe criminal penalties related to the cigarette smuggling. The paper aims at demonstrating that the domestic firm method is based on the will to…
Toward Livable City Centers. Hebron as a Case Study
2012
City centers of Palestinian cities face many urban planning problems; the downtown city is mostly crowded especially in the last few years, because of the increasing population of the cities and the daily migration of the residents from the nearby villages. Everyone can touch the traffic jam problem, the bad quality of urban spaces, the lack of gardens and open spaces in the city center. All this affects negatively the citizens of the city, feeling uncomfortable in the city center. Thus, this study comes to light to draw guidelines to create a comfortable and livable urban environment for people in the city center and to develop the city center to a more environmental, functional, beautiful…
Efficient and accurate methodology for solving multiserver retrial systems
2005
Proposed is a novel methodology for solving retrial systems which is based on the aggregation of levels of the Markov model beyond a given one. Its evaluation concludes that it is more accurate than previous approximations while requiring a low computational cost.
A measurement-based study on the correlations of inter-domain Internet application flows
2014
Internet traffic characterization has a profound impact on network engineering and traffic identification. Existing studies are often carried out on a per-flow basis, focusing on the properties of individual flows. In this paper, we study the interaction of Internet traffic flows and network features from a complex network perspective, focusing on six types of applications: P2P file sharing, P2P stream, HTTP, instant messaging, online games and abnormal traffic. With large-volume traffic flow records collected through proprietary line-speed hardware-based monitors, we construct flow graphs of these different application types. Based on the flow graphs, we calculate the correlation coefficie…
How neurophysiological measures can be used to enhance the evaluation of remote tower solutions
2019
New solutions in operational environments are often, among objective measurements, evaluated by using subjective assessment and judgment from experts. Anyhow, it has been demonstrated that subjective measures suffer from poor resolution due to a high intra and inter-operator variability. Also, performance measures, if available, could provide just partial information, since an operator could achieve the same performance but experiencing a different workload. In this study, we aimed to demonstrate: (i) the higher resolution of neurophysiological measures in comparison to subjective ones; and (ii) how the simultaneous employment of neurophysiological measures and behavioral ones could allow a…
Identification of differential risk hotspots for collision and vehicle type in a directed linear network
2019
Traffic accidents can take place in very different ways and involve a substantially distinct number and types of vehicles. Thus, it is of interest to know which parts of a road structure present an overrepresentation of a specific type of traffic accident, specially for some typologies of collisions and vehicles that tend to trigger more severe consequences for the users being involved. In this study, a spatial approach is followed to estimate the risk that different types of collisions and vehicles present in the central area of Valencia (Spain), considering the accidents observed in this city during the period 2014-2017. A directed spatial linear network representing the non-pedestrian ro…