Search results for " transplantation."
showing 9 items of 1389 documents
Impact of Obesity in Kidney Diseases.
2021
The clinical consequences of obesity on the kidneys, with or without metabolic abnormalities, involve both renal function and structures. The mechanisms linking obesity and renal damage are well understood, including several effector mechanisms with interconnected pathways. Higher prevalence of urinary albumin excretion, sub-nephrotic syndrome, nephrolithiasis, increased risk of developing CKD, and progression to ESKD have been identified as being associated with obesity and having a relevant clinical impact. Moreover, renal replacement therapy and kidney transplantation are also influenced by obesity. Losing weight is key in limiting the impact that obesity produces on the kidneys by reduc…
external iliac artery pseudoaneurysm complicating renal transplantation
2008
Repeated kidney re-transplantation—the Eurotransplant experience: a retrospective multicenter outcome analysis
2020
Transplant international (2020). doi:10.1111/tri.13569
A Patient with Sickle Cell Disease and Recurrent Venous Thromboembolism after Renal Transplantation
2022
Venous thromboembolism (VTE) is a life-threatening complication, especially in case of recurrence. The appropriate duration of anticoagulant treatment following the first event is crucial. Risk factors that increase the risk of recurrence of VTE are many, and include medications, kidney disease, renal transplantation (RT), and a diagnosis of sickle cell disease (SCD). There are currently no guidelines that define the duration of anticoagulant therapy after the first event in a patient with RT. We report a case of recurring episodes of VTE after RT in a SCD patient. Our case suggests that the use of a long-term anticoagulant treatment may be recommended in patients with SCD and RT after the …
Hepatocyte transplantation, a step forward?
2019
Hepatocyte transplantation emerged a few decades ago as a possible strategy to overcome some of the limitations of liver transplantation, among them the availability of organ donors and the functional quality of grafts. Nowadays, allogenic cell transplantation is still to be confirmed as a viable therapeutic option for patients with hereditary metabolic liver diseases. Although we have now overseen 5 decades of basic and animal research in the field, the number of successfully treated patients remains low. Limitations in cell engraftment and selective proliferation of transplanted cells remain a constraint to the generalized use of this therapeutic approach.
How important is the role of iterative liver direct surgery in patients with hepatocellular carcinoma for a transplant center located in an area with…
2022
IntroductionHepatocellular carcinoma (HCC) accounts for nearly 90% of primary liver cancers, with estimates of over 1 million people affected by 2025. We aimed to explore the impacting role of an iterative surgical treatment approach in a cohort of HCC patients within the Milan criteria, associated with clinical risk factors for tumor recurrence (RHCC) after liver transplant (LT) and loco-regional therapies (LRT), as well as liver resection (LR) and/or microwave thermal ablation (MWTA).MethodsWe retrospectively analyzed our experience performed during an 8-year period between January 2013 and December 2021 in patients treated for HCC, focusing on describing the impact on preoperative end-st…
Impacto del quimerismo hematopoyético precoz en el injerto tras trasplante alogénico de progenitores de sangre de cordón umbilical de donante no empa…
2013
El trasplante de sangre de cordón umbilical (TSCU) ha experimentado un auge muy importante en los últimos años como alternativa a la médula ósea y sangre periférica, debido a la dificultad de encontrar donantes altruistas de estas fuentes de progenitores hematopoyéticos. Los datos clínicos disponibles hasta la fecha muestran una supervivencia libre de enfermedad similar a la observada con el trasplante de médula ósea (TMO) o sangre periférica (TSP). Sin embargo, como consecuencia de la baja dosis celular contenida en la SCU, la tasa de fallo de injertos es más elevada y el tiempo hasta la recuperación de la neutropenia más prolongado. Gran parte de la investigación en el terreno del TSCU se…
Non-HLA Antibodies in Hand Transplant Recipients Are Connected to Multiple Acute Rejection Episodes and Endothelial Activation
2022
The role of anti-HLA antibodies in transplant rejection is well-known but the injury associated with non-HLA antibodies is now widely discussed. The aim of our study was to investigate a role of non-HLA antibodies in hand allografts rejection. The study was performed on six patients after hand transplantation. The control group consisted of: 12 kidney transplant recipients and 12 healthy volunteers. The following non-HLA antibodies were tested: antibody against angiotensin II type 1 receptor (AT1R-Ab), antibody against endothelin-1 type-A-receptor (ETAR-Ab), antibody against protease-activated receptor 1 (PAR-1-Ab) and anti-VEGF-A antibody (VEGF-A-Ab). Chosen proinflammatory cytokines (Il-1…
Pēcoperācijas perioda izvērtējums pēc radzenes transplantācijas vispārējā anestēzijā
2020
Bakalaura darba tēma ir “Pēcoperācijas perioda izvērtējums pēc radzenes transplantācijas vispārējā anestēzijā”. Darba tēmas aktualitāte ir tajā, ka radzenes transplantācijas operācijas visā pasaulē un Latvijā tiek veiktas arvien vairāk, tāpēc ir būtiski novērtēt pēcoperācijas periodu pēc šīm operācijām, lai izvērtēt aprūpes procesu, pacientu sūdzības un dokumentācijas kvalitāti un nepieciešamības gadījumā veikt uzlabojums. Darba mērķis ir izvērtēt pēcoperācijas periodu pacientam pēc radzenes transplantācijas operācijas vispārējā anestēzijā. Bakalaura darba mērķa saniegšanai autore izvirzija sekojošus darba uzdevumus - apkopot un analizēt zinātnisko literatūru par radzenes transplantāciju un…