Search results for "ètica"
showing 10 items of 343 documents
RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway.
2021
AbstractmRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1. Here we show that nucleocytoplasmic shuttling of several yeast mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is regulated by RNA-controlled binding of the karyopherin Kap120 to two nuclear localization sequences (NLSs) in Xrn1, location of one of which is conserved from yeast to human. The decaying RNA binds and masks NLS1, establishing a link between mRNA decay and Xrn1 shuttling. Preventing Xrn1 import, either by deleting KAP120 or mutating the two Xrn1 NLSs, compromises transcription and, unexpectedly, also cytoplas…
Editorial misconduct: the case of online predatory journals.
2021
The number of publishers that offer academics, researchers, and postgraduate students the opportunity to publisharticles and book chapters quickly and easily has been growing steadily in recent years. This can be ascribed to avariety of factors, e.g., increasing Internet use, the Open Access movement, academic pressure to publish, and theemergence of publishers with questionable interests that cast doubt on the reliability and the scientific rigor of thearticles they publish.All this has transformed the scholarly and scientific publishing scene and has opened the door to theappearance of journals whose editorial procedures differ from those of legitimate journals. These publishers arecalled…
La categoría de montaje en la construcción literaria
1987
El presente texto se aproxima a la literatura de vanguardia mediante el concepto de montaje, entendiéndolo como un principio operativo teórico que se extiende por las distintas artes.
Arithmetica / [Jordanus Nemorarius] ; Cum demonstrationibus Jacobi Fabri Stapulensis. Elementa musicalia ; Epitome in arithmeticam Boethii ; Rythmima…
1496
Sig. a-i8 Ll. gòt. - 2 tam. - Núm. de lín. variable. - Esp. o min. p. inic. - Grav. - Registre. - Text amb postil·les marginals. - Filigr.: gerro
Quadern de pràctiques de Mètodes en Biologia Molecular i Enginyeria Genètica
2011
El document inclou la descripció d'alguns experiments de laboratori sobre Enginyeria Genètica que són aplicables per a estudiants de graus de Bioquímica i Ciències Biomèdiques i de Biotecnologia El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València.
A View on the philosophy of music
2012
Philosophy of music is a second-level reflection on the nature of music and our experience of it. Music is a practice fraught with meaning and value in the lives of many people and occupies an important place in our artistic culture. However, it raises philosophical questions perhaps more difficult tan other artistic practices. This paper points out some problems related to the major topics that have been the focus of discussion in recent decades, that we can group into six main areas: methodological issues concerning research on the philosophy of music; issues relating to the ontology of music; topics concerning the aesthetics of music; issues regarding the semantics of music; topics regar…
La música y los mitos
1999
La música y los mitos: he aquí un tema inmenso, denso y complejo, que puede ser abordado desde distintos puntos de vista sin llegar a agotarlo. Si deseamos profundizar en las posibles relaciones que ambas creaciones universales han mantenido a lo largo de la historia, ante nosotros se abren varias perspectivas, bien sea que subrayemos la incidencia que la música ha tenido en el proceso de nacimiento y transmisión de los mitos, bien sea que, a la inversa, destaquemos lo que los mitos nos narran en torno al surgimiento y los efectos de la música, o, en tercer lugar, que comparemos y contrastemos las características estructurales que poseen ambos productos culturales, con el fin de que mutuame…
Una perspectiva sobre la filosofía de la música
2012
La filosofía de la música es una reflexión de segundo nivel sobre la naturaleza de la música y nuestra experiencia de ella. La música es una práctica cargada de sentido y valor en las vidas de mucha gente y ocupa un lugar importante en nuestra cultura artística.
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
2020
AbstractEating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], …
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
2015
G.B. and S.N. acknowledge funding support for this work from the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. P.H.L. is supported by US National Institute of Mental Health (NIMH) grant K99MH101367. Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an an…