6533b855fe1ef96bd12affa0
RESEARCH PRODUCT
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Samuel KupermanLeila KarhunenGeòrgia EscaramísSébastien GuillaumeKelly L. KlumpDavid C. WhitemanColin HodgkinsonStephanie H. WittArtemis TsitsikaHana PapezovaRenato PolimantiRenato PolimantiP. Eline SlagboomPeter ZillJakob GroveJakob GroveToni-kim ClarkeMichael SoykaJennifer JordanSteven GallingerPhilip GorwoodPhilip GorwoodPreben Bo MortensenPreben Bo MortensenYuri MilaneschiIngrid MeulenbeltJen Chyong WangMarkus M. NöthenKatrin MännikKatrin MännikHenry R. KranzlerMichael M. VanyukovAnna Keski-rahkonenWilliam G. IaconoRaymond K. WaltersRaymond K. WaltersStephanie Le HellardStephanie Le HellardBochao Danae LinVesna Boraska PericaVesna Boraska PericaMarion RobertsPatrick F. SullivanPatrick F. SullivanSteven CrawfordMark A. FryeMelissa A. Munn-chernoffHakon HakonarsonHakon HakonarsonAndreas BirgegårdAndreas BirgegårdRobert CulverhouseAlexis C. EdwardsJerome C. FooAlessandro RotondoBrenda W.j.h. PenninxLaura M. HackMichael T. LynskeyMario MajAlessio Maria MonteleoneTed Reichborn-kjennerudTed Reichborn-kjennerudJulie K. O'tooleMarta Tyszkiewicz-nwaforMatt McgueJulien BryoisMartina De ZwaanNorbert DahmenStefanie Heilmann-heimbachDeborah KaminskáBenedetta NacmiasNicholas G. MartinAnna R. DochertyChristopher HübelChristopher HübelNancy L. PedersenJanet TreasureWilliam E. CopelandRoger A.h. AdanRoger A.h. AdanJaakko KaprioAarno PalotieAarno PalotieAarno PalotieL. John HorwoodMaria La ViaPhilippe CourtetVirpi M. LeppäJudy L. SilbergJason D. BoardmanFazil AlievWade H. BerrettiniDoo Sup ChoiYoul-ri KimKonstantinos HatzikotoulasHarriet De WitSandra A. BrownElisabeth WidenCaroline HaywardNicholas J. SchorkPenelope A. LindRalph E. TarterJana StrohmaierAllan S. KaplanAllan S. KaplanRichard A. GruczaBradley T. WebbAngela FavaroDalila PintoHelena GasparHelena GasparAndrew W. BergenBeate Herpertz-dahlmannRobert LevitanWolfgang GäbelXavier EstivillEmma C. JohnsonKonstantinos TziouvasLindsay A. FarrerLindsay A. FarrerLindsay A. FarrerLenka ForetovaMarc A. SchuckitJoanna M. BiernackaAndré ScheragRobbee WedowRobbee WedowRobbee WedowAbraham A. PalmerAmy E. AdkinsFranziska DegenhardtLouisa DegenhardtJurjen J. LuykxMarius Lahti-pulkkinenBrien P. RileyMonika RidingerMatteo CassinaHarry BrandtYiran GuoStephan RipkeStephan RipkeStephan RipkePalmiero MonteleoneKatri RäikkönenJonathan R. I. ColemanJonathan R. I. ColemanMartin A. KennedyStephen W. SchererIoanna TachmazidouCatherine M. OlsenBernice PorjeszEsther WaltonYi-ling ChouNicolas RamozTetsuya AndoAndres MetspaluBertram Müller-myhsokBrion S. MaherSarah BertelsenMelanie L. SchwandtJaniece E. DesocioMargaret KeyesJohn F. PearsonDongbing LaiPaul LichtensteinJames MackillopGeorge DedoussisJari LahtiUlrike SchmidtStefan EhrlichAmanda G. WillsTeemu PalviainenDavid GoldmanDavid GoldmanElena TenconiDimitris DikeosScott I. VriezeSietske G. HelderKatharina BuehrenHongyu ZhaoSara McdevittJolanta LissowskaJoseph M. BodenLi-shiun ChenSusanne LucaeSara MarsalDan RujescuClaes NorringClaes NorringHoward J. EdenbergVictor M. KarpyakFragiskos GonidakisPer HoffmannPer HoffmannPer HoffmannChristopher S. FranklinKarin EgbertsJohanna GiurannaStefan HermsStefan HermsLeah WetherillStephanie ZerwasAnthony BatzlerElliot C. NelsonJouke-jan HottengaMarcella RietschelIoanna NtallaVictor HesselbrockSarah M. HartzMarie NavratilovaFalk KieferMartien J H KasMartien J H KasRichard J. RoseAndrew C. HeathJin P. SzatkiewiczLenka SlachtovaLisa LilenfeldKatherine A. HalmiJohn P. RiceAnjali K. HendersChristian DinaNorbert WodarzSatu MännistöHamdi MbarekShuyang YaoVladimir JanoutAlison GoateBettina KonteAlexandra SchosserDanfeng ChenKirsty KiezebrinkEuijung RyuDana B. HancockJames MitchellSarah E. MedlandIna GieglingValdo RiccaScott D. GordonGabrielle KollerSamuli RipattiLaura M. ThorntonAlison D. MurrayMorten MattingsdalZeynep YilmazJens TreutleinKathleen K. BucholzTim B. BigdeliEric F. Van FurthHermine H. MaesKen B. HanscombeSandra Sanchez-roigeDaniela DegortesMonica ForzanManuel MattheisenRichard ShervaScott J. CrowMikael LandénMikael LandénWolfgang HerzogJeanette N. McclintickTõnu EskoTõnu EskoLouis FoxWolfgang MaierLiselotte PetersenLiselotte PetersenLaura J. BierutRoseann E. PetersonGursharan KalsiKathleen Mullan HarrisMargarita C T Slof-op 'T LandtTamara L. WallPatrik K. E. MagnussonUnna N. DannerStephan ZipfelUlrich W. PreussElisa DocampoD. Blake WoodsideAlfonso TortorellaAlfonso TortorellaBenjamin W. DomingueFranziska RitschelJohan G. ErikssonJohan G. ErikssonAnu RaevuoriBenjamin M. NealeBenjamin M. NealeMarcus IsingAnnemarie A. Van ElburgFilip RybakowskiMaureen ReynoldsTracey D. WadeManfred M. FichterMonica Gratacos MayoraClaudette BoniAndreas J. ForstnerAndreas J. ForstnerAndreas J. ForstnerJohn WhitfieldSilviu-alin BacanuMatthew B. McqueenAndrew M. McintoshNorbert ScherbaumTatiana ForoudGun Peggy KnudsenSven CichonSven CichonSven CichonChristian J. HopferJosef FrankEleftheria ZegginiFederica TozziNadia MicaliNadia MicaliDanielle M. DickPamela A. F. MaddenChristian R. MarshallJohannes HebebrandFernando Fernández-arandaRoel A. OphoffRoel A. OphoffRoland BurghardtNathaniel ThomasLeonid PadyukovNancy L. SacconeAnu LoukolaFabian StreitJames L. KennedyJames L. KennedyJessica H. BakerPeter McguffinWalter H. KayePei-hong ShenAnne FarmerRoger D. ConeIlka BoehmJacquelyn L. MeyersPaolo SantonastasoMaurizio ClementiSusana Jiménez-murciaGudrun WagnerAnke HinneyRichard ParkerJames I. HudsonNathan A. GillespieMichael StroberMichael StroberJohn I. NurnbergerSandro SorbiDorret I. BoomsmaBeata ŚWiątkowskaJanne Tidselbak LarsenJanne Tidselbak LarsenKenneth S. KendlerHidetoshi InokoJessica E. SalvatoreHunna J. WatsonHunna J. WatsonHunna J. WatsonJochen SeitzJacques PantelKarl MannHang ZhouHang ZhouAntonio JuliàOliver S. P. DavisNancy DiazgranadosKrista FischerJohn K. HewittKaren S. MitchellKaren S. MitchellJoanna HauserEric O. JohnsonEric O. JohnsonCraig JohnsonE. Jane CostelloAgnieszka SłopieńDong LiLaramie E. DuncanArpana AgrawalGrant W. MontgomeryGrant W. MontgomeryManuel FöckerThomas WergeLannie LigthartAndreas KarwautzRaquel RabionetRaquel RabionetKenneth KrauterJoel GelernterJames J. CrowleyJames J. CrowleyCynthia M. BulikCynthia M. BulikPaola Giusti-rodríguezLaura M. HuckinsLaura M. HuckinsGerome BreenGerome BreenMichael C. StallingsDaniel E. AdkinsPierre J. MagistrettiPierre J. MagistrettiJohn KramerLars AlfredssonHartmut ImgartAnnette M. HartmannOle A. AndreassenMonika Dmitrzak-weglarzsubject
Netherlands Twin Register (NTR)Alcoholism/geneticsSchizophrenia/genetics[SDV]Life Sciences [q-bio][SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthMedizinMedicine (miscellaneous)Genome-wide association studyAlcohol use disorderAnorexia nervosaLinkage Disequilibriumddc:616.89[SCCO]Cognitive science0302 clinical medicineRisk FactorsTobacco Use Disorder/geneticsSubstance-Related Disorders/genetics0303 health sciences[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyFactors de risc en les malaltiesBulimia nervosaFeeding and Eating Disorders/geneticseating disorders; genetic correlation; substance useTobacco Use Disordergenetic correlation3. Good healthFenotip[SDV] Life Sciences [q-bio]Psychiatry and Mental healthAlcoholismEating disordersPhenotypeSchizophreniaDrinking of alcoholic beverageseating disorderConsum d'alcoholMajor depressive disorder/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingmedicine.symptomDepressive Disorder Major/geneticseating disorders genetic correlation substance useClinical psychologySubstance abuseRisk factors in diseasesSubstance-Related Disorderssubstance useeating disordersPolymorphism Single NucleotideArticleFeeding and Eating Disorders03 medical and health sciencesSDG 3 - Good Health and Well-beingmental disorders/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_GeneticsmedicineHumansTrastorns de la conducta alimentària030304 developmental biologyGenetic associationPharmacologyeating disorders ; genetic correlation ; substance useDepressive Disorder MajorBinge eatingbusiness.industry[SCCO.NEUR]Cognitive science/Neuroscience[SCCO.NEUR] Cognitive science/Neurosciencesubstance use.[SCCO] Cognitive sciencemedicine.diseaseComorbidityTwin study030227 psychiatryAbús de substàncies[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthSchizophreniabusinessGenètica030217 neurology & neurosurgery[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyGenome-Wide Association Studydescription
AbstractEating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder (MDD). Total sample sizes per phenotype ranged from ~2,400 to ~537,000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg=0.18; false discovery rate q=0.0006), cannabis initiation and AN (rg=0.23; q<0.0001), and cannabis initiation and AN with binge-eating (rg=0.27; q=0.0016). Conversely, significant negative genetic correlations were observed between three non-diagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge-eating (rgs=-0.19 to −0.23; qs<0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for MDD loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships between these behaviors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-02-16 |