0000000000381200

AUTHOR

Nathan A. Gillespie

showing 3 related works from this author

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

2018

AbstractLiability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM - IV diagnosed AD. Genome - wide data on 14,904 individuals with AD and 37,944 controls from 28 case / control and family - based studies were meta - analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome - wide significant effects of different ADH1B variants were identified in European (rs1229984; p = …

0303 health sciencesmedicine.medical_specialtybiologyGenetic genealogyAlcohol dependenceADH1BGenome-wide association studybiology.organism_classificationmedicine.diseaseGenetic correlation3. Good health03 medical and health sciences0302 clinical medicineSchizophreniamedicineCannabisPsychiatry030217 neurology & neurosurgeryDepression (differential diagnoses)030304 developmental biology
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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

2020

AbstractEating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], …

Netherlands Twin Register (NTR)Alcoholism/geneticsSchizophrenia/genetics[SDV]Life Sciences [q-bio][SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthMedizinMedicine (miscellaneous)Genome-wide association studyAlcohol use disorderAnorexia nervosaLinkage Disequilibriumddc:616.89[SCCO]Cognitive science0302 clinical medicineRisk FactorsTobacco Use Disorder/geneticsSubstance-Related Disorders/genetics0303 health sciences[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyFactors de risc en les malaltiesBulimia nervosaFeeding and Eating Disorders/geneticseating disorders; genetic correlation; substance useTobacco Use Disordergenetic correlation3. Good healthFenotip[SDV] Life Sciences [q-bio]Psychiatry and Mental healthAlcoholismEating disordersPhenotypeSchizophreniaDrinking of alcoholic beverageseating disorderConsum d'alcoholMajor depressive disorder/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingmedicine.symptomDepressive Disorder Major/geneticseating disorders genetic correlation substance useClinical psychologySubstance abuseRisk factors in diseasesSubstance-Related Disorderssubstance useeating disordersPolymorphism Single NucleotideArticleFeeding and Eating Disorders03 medical and health sciencesSDG 3 - Good Health and Well-beingmental disorders/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_GeneticsmedicineHumansTrastorns de la conducta alimentària030304 developmental biologyGenetic associationPharmacologyeating disorders ; genetic correlation ; substance useDepressive Disorder MajorBinge eatingbusiness.industry[SCCO.NEUR]Cognitive science/Neuroscience[SCCO.NEUR] Cognitive science/Neurosciencesubstance use.[SCCO] Cognitive sciencemedicine.diseaseComorbidityTwin study030227 psychiatryAbús de substàncies[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthSchizophreniabusinessGenètica030217 neurology & neurosurgery[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyGenome-Wide Association Study
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Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins.

2017

AbstractEarly maturation, indexed by pubertal development (PD), has been associated with earlier initiation and greater frequency of adolescent substance use, but this relationship may be biased by confounding factors and effects that change across development. Using a population-based Finnish twin sample (N = 3,632 individuals), we conducted twin modeling and multilevel structural equation modeling of the relationship between PD and substance use at ages 12–22. Shared environmental factors contributed to early PD and heavier substance use for females. Biological father absence was associated with early PD for boys but not girls, and did not account for the relationship between PD and subst…

Maleteini-ikäisetpubertyLongitudinal studyTwinsSocial EnvironmentDevelopmental psychologyNicotineALCOHOL-USE0302 clinical medicineDevelopmental and Educational PsychologyadolescentsLongitudinal Studiestwin studyYoung adultChildta515FATHER ABSENCEFinlandASSOCIATIONSRISKyoutheducation.field_of_studypäihteetParentingREPRODUCTIVE DEVELOPMENT05 social sciencesConfoundinglongitudinal studyta3141ta3142murrosikä3142 Public health care science environmental and occupational healthPsychiatry and Mental health5141 SociologyFemaleSMOKINGPsychologyearly pubertal development050104 developmental & child psychologymedicine.drugMediation (statistics)AdolescentAlcohol DrinkingSubstance-Related DisordersPopulationAGE 14substance usepitkittäistutkimusStructural equation modelingPeer GroupArticlePUBERTAL DEVELOPMENTENVIRONMENTAL-INFLUENCES03 medical and health sciencesYoung AdultDRINKINGIntervention (counseling)medicineDiseases in TwinsHumans0501 psychology and cognitive scienceseducationkaksostutkimusmaturationterveyskäyttäytyminen030217 neurology & neurosurgeryDevelopment and psychopathology
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