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showing 10 items of 360 documents
FROM INTERCONNECTORS TO ANODE MATERIALS FOR IT-SOFCs:THE ROLE OF IRON IN La1-xSrxCr1-yFeyO3-δ
2013
Selective Uptake of Cylindrical Poly(2-Oxazoline) Brush-AntiDEC205 Antibody-OVA Antigen Conjugates into DEC-Positive Dendritic Cells and Subsequent T…
2014
To achieve specific cell targeting by various receptors for oligosaccharides or antibodies, a carrier must not be taken up by any of the very many different cells and needs functional groups prone to clean conjugation chemistry to derive well-defined structures with a high biological specificity. A polymeric nanocarrier is presented that consists of a cylindrical brush polymer with poly-2-oxazoline side chains carrying an azide functional group on each of the many side chain ends. After click conjugation of dye and an anti-DEC205 antibody to the periphery of the cylindrical brush polymer, antibody-mediated specific binding and uptake into DEC205(+) -positive mouse bone marrow-derived dendri…
Multiwavelength monitoring of BD+53°2790 , the optical counterpart to 4U 2206+54
2005
We present the results of our long-term monitoring of BD+53 2790, the optical counterpart to the X-ray source 4U~2206+54. Unlike previous studies that classify the source as a Be/X-ray binary, we find that its optical and infrared properties differ from those of typical Be stars: the variability of the V/R ratio is not cyclical; there are variations in the shape and strength of the H$\alpha$ emission line on timescales less than 1 day; and no correlation between the EW and the IR magnitudes or colors is seen. Our observations suggest that BD+53 2790 is very likely a peculiar O9.5V star. In spite of exhaustive searches we cannot find any significant modulation in any emission line parameter …
Stability of FeVO4-II under Pressure: A First-Principles Study
2022
In this work, we report first-principles calculations to study FeVO4 in the CrVO4 -type (phase II) structure under pressure. Total-energy calculations were performed in order to analyze the structural parameters, the electronic, elastic, mechanical, and vibrational properties of FeVO4 -II up to 9.6 GPa for the first time. We found a good agreement in the structural parameters with the experimental results available in the literature. The electronic structure analysis was complemented with results obtained from the Laplacian of the charge density at the bond critical points within the Quantum Theory of Atoms in Molecules methodology. Our findings from the elastic, mechanic, and vibrational p…
B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure
2019
Aims In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. Methods and results The Acute Kidney Injury NGAL Evaluation of Symptomatic heart faIlure Study (AKINESIS) was a prospective, international, multicentre study of AHF patients. Severe WRF (sWRF) was a sustained increase of >= 44.2 mu mol/L (0.5 mg/dL) or >= 50% in creatinine, non-severe WRF (nsWRF) was a non-sustained increase of >= 26.5 mu mol/L (0.3 mg/dL) or >= 50% in cr…
Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure
2021
Aims Improving renal function (IRF) is paradoxically associated with worse outcomes in acute heart failure (AHF), but outcomes may differ based on response to decongestion. We explored if the relationship of IRF with mortality in hospitalized AHF patients differs based on successful decongestion.Methods and results We evaluated 760 AHF patients from AKINESIS for the relationship between IRF, change in B-type natriuretic peptide (BNP), and 1-year mortality. IRF was defined as a >= 20% increase in estimated glomerular filtration rate (eGFR) relative to admission. Adequate decongestion was defined as a >= 40% decrease in last measured BNP relative to admission. IRF occurred in 22% of pat…
DELL’UTRI E CONTRADA “GEMELLI DIVERSI”: È LA REVISIONE EUROPEA LO STRUMENTO DI OTTEMPERANZA ALLE SENTENZE CEDU
2017
La Cassazione nega l’origine giurisprudenziale del concorso esterno in associazione mafiosa e individua il rimedio della revisione europea per l’attuazione della decisione CEDU nei confronti di soggetti in posizioni simili a quella di Contrada. Il percorso offre l’occasione per riflettere sulla connotazione “oggettiva” della prevedibilità e sull’uguaglianza di trattamento dei condannati. Italian supreme Court denies that the origin of external participation in mafia-type criminal association lies in case law and envisages the European review as the tool to comply with ECtHR judgements in similar cases to that of Contrada. This jurisprudence provides a proper opportunity for an in-depth exam…
Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells
2017
Langerhans cells (LCs) are antigen-presenting cells in the epidermis whose roles in antigen-specific immune regulation remain incompletely understood. Desmoglein 3 (Dsg3) is a keratinocyte cell-cell adhesion molecule critical for epidermal integrity and an autoantigen in the autoimmune blistering disease pemphigus. Although antibody-mediated disease mechanisms in pemphigus are extensively characterized, the T cell aspect of this autoimmune disease still remains poorly understood. Herein, we utilized a mouse model of CD4+ T cell-mediated autoimmunity against Dsg3 to show that acquisition of Dsg3 and subsequent presentation to T cells by LCs depended on the C-type lectin langerin. The lack of…
On the dynamics of the AB Doradus system
2006
We present an astrometric analysis of the binary systems ABDorA /ABDorC and ABDorBa / ABDorBb. These two systems of well-known late-type stars are gravitationally associated and they constitute the quadruple ABDoradus system. From the astrometric data available at different wavelengths, we report: (i) a determination of the orbit of ABDorC, the very low mass companion to ABDorA, which confirms the mass estimate of 0.090Msun reported in previous works; (ii) a measurement of the parallax of ABDorBa, which unambiguously confirms the long-suspected physical association between this star and ABDorA; and (iii) evidence of orbital motion of ABDorBa around ABDorA, which places an upper bound of 0.4…
Fixed point iterative schemes for variational inequality problems
2018
In a wide class of evolutionary processes, the problem of computing the solutions of an initial value problem is encountered. Here, we consider projected dynamical systems in the sense of \cite{Daniele} and references therein. Precisely, a projected dynamical system is an operator which solves the initial value problem: \begin{equation}\label{PDS}\frac{dx(t)}{dt}= \Pi_{\mathbb{K}}\left(x(t),-F(x(t))\right), \quad x(0)=x_0 \in \mathbb{K}, \, t \in [0,+\infty[,\tag{P}\end{equation} where $\mathbb{K}$ is a convex polyhedral set in $\mathbb{R}^n$, $F: \mathbb{K} \to \mathbb{R}^n$ and $\Pi_{\mathbb{K}}: \mathbb{R} \times \mathbb{K} \to \mathbb{R}^n$ is given as follows $\Pi_{\mathbb{K}}(x,-F(x))…