Search results for "004"

Treatment of isolated ascending aortic aneurysm by off-pump epiaortic wrapping is safe and durable.

2016

OBJECTIVES: Isolated ascending aortic aneurysm (iAA) is usually treated by open graft repair requiring sternotomy, cardiopulmonary bypass (CPB) and cardioplegia. This approach carries significant mortality in older patients or those presenting with comorbidities. We report an original series of patients presenting with iAA and treated with epiaortic wrapping by using a synthetic mesh. This less invasive aortic repair technique allows reducing the aortic diameter to a predefined value and is performed without CPB. METHODS: Data from patients presenting with an iAA and treated with the wrapping technique (WT) by polypropylene/polyester mesh from November 2006 to July 2015 were collected. The …

Le passage à une économie fondée sur la connaissance entraîne-t-il une transformation des contenus de l'éducation ?

2022

International audience; Nos économies sont de plus en plus basées sur la connaissance. Les exigences des entreprises sur le marché du travail doivent alors amener les établissements d'enseignement à prêter une attention toute particulière aux contenus de ce qui est enseigné. La présentation des résultats d'une recherche empirique internationale originale, menée auprès de diplômés de l'enseignement supérieur, permet de préciser les compétences les plus recherchées dont celles qui concourent à l'innovation. L'auteur souligne ainsi, au-delà de l'influence des variables traditionnelles, l'importance des compétences en informatique, de la pratique d'une langue étrangère, de la maîtrise du raison…

“Much Ado About Something: Nineteenth-Century American Writers and the Atlantic Cable”

2022

Cet article décrit et analyse les réactions de plusieurs grands auteurs américains (Thoreau, Longfellow, Irving, Melville, Whittier, Whitman et Emerson) au succès en 1858 du premier lien télégraphique transatlantique entre les États-Unis et l’Europe. Ces réponses à cet exploit technologique apparaissaient dans des journaux privés, des lettres, des éditoriaux et des notes marginales; elles étaient parfois incorporées dans des œuvres littéraires. Dans presque tous les cas, les réactions peuvent...

Linguistica Lettica, Nr. 14

2005

Diseño, desarrollo e implementación de una plataforma bioinformática orientada al análisis y gestión de infomación en epidemiología molecular

2011

La investigación genética y epidemiológica de las enfermedades infecciosas requiere actualmente grandes cantidades de datos. En un laboratorio de tamaño medio, la información necesaria para realizar estudios de investigación suele almacenarse de forma independiente en diferentes formatos y lugares, lo que dificulta su gestión y análisis. Esta organización de la información conlleva que el trabajo habitual en un laboratorio se realice de forma lenta y desordenada. En esta situación, la integración de la información es de vital importancia para poder llevar a cabo estos trabajos de forma eficiente, sistematizada y común a todos los investigadores del laboratorio. La principal motivación de es…

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.

2015

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation. Multiple cell types can sense GM-CSF, but the identity of the pathogenic GM-CSF-responsive cells is unclear. By using conditional gene targeting, we systematically deleted the GM-CSF receptor (Csf2rb) in specific subpopulations throughout the myeloid lineages. Experimental autoimmune encephalomyelitis (EAE) progressed normally when either classical dendritic cells (cDCs) or neutrophils lacked GM-CSF responsiveness. The development of tissue-invading monocyte-derived dendritic cells (moDCs) was also unperturbed upon Csf2r…

Fuzzy subgroup mining for gene associations

2004

When studying the therapeutic efficacy of potential new drugs, it would be much more efficient to use predictors in order to assess their toxicity before going into clinical trials. One promising line of research has focused on the discovery of sets of candidate gene profiles to be used as toxicity indicators in future drug development. In particular genomic microarrays may be used to analyze the causality relationship between the administration of the drugs and the so-called gene expression, a parameter typically used by biologists to measure its influence at gene level. This kind of experiments involves a high throughput analysis of noisy and particularly unreliable data, which makes the …

Going beyond histology. Synchrotron micro-computed tomography as a methodology for biological tissue characterization: from tissue morphology to indi…

2009

Current light microscopic methods such as serial sectioning, confocal microscopy or multiphoton microscopy are severely limited in their ability to analyse rather opaque biological structures in three dimensions, while electron optical methods offer either a good three-dimensional topographic visualization (scanning electron microscopy) or high-resolution imaging of very thin samples (transmission electron microscopy). However, sample preparation commonly results in a significant alteration and the destruction of the three-dimensional integrity of the specimen. Depending on the selected photon energy, the interaction between X-rays and biological matter provides semi-transparency of the spe…

Enseignement artistique et marché, quelles relations ? Pour une conception élargie de la qualification

2022

International audience; L'objet de l'analyse est de relier l'enseignement (ses méthodes et ses contenus) au fonctionnement du marché du travail, en se concentrant spécifiquement sur les formations artistiques. L'auteur part des caractéristiques de l’œuvre d'art et montre comment ce bien hors du commun est, de façon a priori paradoxale et avec d'éventuelles tensions, enseigné. Il pose la question de la médiation du maître, de la place de la certification. Il en pointe les conséquences sur la relation - difficile - entre la formation et l'emploi et, en réponse, la tendance à la professionnalisation vers laquelle semblent s'orienter les écoles d'art.

The use of Endurant stent-graft for abdominal aortic aneurysm: the story about extension of instruction for use with persistent good results of stent…

2012

The Endurant stent-graft (Medtronic, Inc., Minneapolis, MN, USA) is a latest generation device for the treatment of abdominal aortic aneurysm. The idea behind designing such a graft came from the intention to broad the instruction for use (IFU) and to enable it to treat more challenging anatomy including the 10mm neck lengths, and more severe suprarenal and infrarenal angulations. Endurant stent-graft has active fixation through suprarenal stent with anchoring pins to provide migration resistance, optimized heights of stents and spacing between them for improved flexibility and conformability, low-profile delivery system with hydrophilic coating and controlled simple deployment mechanism. S…