Search results for "030209 endocrinology & metabolism"
showing 10 items of 1146 documents
Regular Strength and Sprint Training Counteracts Bone Aging: a 10- year Follow-up in Male Masters Athletes
2021
According to cross-sectional and interventional studies, high-intensity strength and impact-type training provide a powerful osteogenic stimulus even in old age. Longitudinal evidence on the ability of high-intensity training to attenuate age-related bone deterioration is currently lacking, however. This follow-up study assessed the role of continued strength and sprint training on bone aging in 40- to 85-year-old male sprinters (n=69) with long-term training background. pQCT-derived bone structural, strength and densitometric parameters of the distal tibia (5% distal-proximal tibia length) and tibial midshaft (50% length) were assessed at baseline and after 10 years. The groups of well-tra…
Comment on "Effects of Elastic Resistance Band Exercise on Postural Balance, Estrogen, Bone Metabolism Index, and Muscle Strength of Perimenopausal P…
2017
2021
The aim of the study was to analyze sleep duration and behaviors in relation to psychological parameters in children and adolescents with obesity seeking inpatient weight-loss treatment in comparison to normal-weight children, and whether or not these variables would improve during the time course of treatment. Sixty children or adolescents with overweight and obesity (OBE) and 27 normal-weight (NW) peers (age: 9–17) were assessed for subjective sleep measures through self-reported and parent-reported questionnaires, as well as body weight, body composition, and psychological questionnaires. The OBE participants were assessed upon admission and before discharge of an inpatient multidiscipli…
Relación del Índice de Masa Corporal elevado asociado a la postura del pie y la actividad deportiva en la edad pediátrica
2019
[Resumen] Objetivos: Establecer el tipo de pie y el Índice de Masa Corporal que predomina en la edad pediátrica. Material y métodos: Se ha realizado una descriptiva de la muestra estudio analizando la prueba del Foot Posture Índex y el Índice de Masa Corporal a 31 sujetos de 8 años. También se ha analizado la actividad deportiva y la frecuencia con la que se realiza además de valorar si llevaban tratamiento ortopodológico. Resultados: El 50% de la muestra presenta pies pronados. El Índice de Masa Corporal es mayor en el sexo masculino, siendo el 30% de los sujetos los que presentan sobrepeso y el 12% de la muestra obesidad. Conclusiones: No se puede concluir que los pacientes con un Índice …
Modelling of Water Supply Costs
2017
Water supply tariffs setting is a labour intensive regulatory procedure; currently number of informative and procedural shortages and problems exist. The aim of the current research is improvement of methodology for determination of the substantiated costs for provision of water services. A working hypothesis was advanced to modernize the methodology: the specific costs (/m3) required for the provision of water services in a specific region is a variable multi-parameter function of key performance indicators. There is preferred a benchmark modelling procedure, which is based on the factual cases (declared indicators of water utilities) and synthesis of the general regularity. The model is d…
Magnesium Role in Health and Longevity
2018
Reduced Magnesium (Mg) intake is a frequent cause of Mg deficit with age. A decreased intestinal Mg absorption and an increased Mg loss may also contribute, as well as the use of medicaments. Furthermore, Mg requirements may be higher with aging. Alterations of Mg metabolism with age, cellular Mg transport systems and problems with measurement methods are discussed. Mg contained in water is more bio-available than Mg in food and it is a possible alternative to Mg supplementation in the correction of Mg deficiencies. Mild to moderate Mg deficits are generally asymptomatic and clinical signs are usually absent or non-specific. Hyperemotionality, tremor, asthenia, sleep disorders, and amnesic …
Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options
2019
The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, and a quiescent state. Neuroblastoma (NB) is considered a neuroendocrine tumor and is the most common extracranial neoplasm in children. NB pathogenesis has frequently been associated with epigenetic dysregulation and a failure to implement a differentiation program. The origin, characteristics, and isolation of the CSC subpopulation in NB are still incompletely understood, des…
Impact of Glucose-Lowering Medications on Cardiovascular and Metabolic Risk in Type 2 Diabetes
2020
Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular (CV) disease. Among the well-known pathophysiologic factors, crucial roles are played by endothelial dysfunction (caused by oxidative stress and inflammation hyperglycemia-linked), increased activity of nuclear factor kB, altered macrophage polarization, and reduced synthesis of resident endothelial progenitor cells. As consequence, a potentially rapid progression of the atherosclerotic disease with a higher propensity to unstable plaque is arguable, finally leading to significantly increased cardiovascular mortality. Main managements are focused on both prevention and early diagnosis, by target…
Metabolic disorders during pregnancy and postpartum cardiometabolic risk
2018
Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome, and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia. Hypertensive disease of pregnancy (HDP) is more likely to be an accompanying co-morbidity in pregnancies complicated with GDM. There is still inc…
Small, dense LDL: An update
2017
Purpose of review In this review, we summarize the latest findings on small, dense LDL (sdLDL) atherogenic particles, including their associations with other biomarkers. Recent findings Increased sdLDL levels have been reported not only in different metabolic disorders such as diabetes, obesity and metabolic syndrome, but also in patients with rheumatoid and psoriatic arthritis as well as hypothyroidism. A wide range of lipid-lowering, as well as other drug classes, including novel antidiabetic agents and nutraceuticals, exert favourable effects on these atherogenic particles. The 'gold standard' methodology for the assessment of sdLDL has not been established yet. However, the association …