Search results for "1006"
showing 10 items of 45 documents
RISK OF CARDIOVASCULAR DISEASE MORBIDITY AND MORTALITY IN FRAIL AND PRE-FRAIL OLDER ADULTS:RESULTS FROM A META-ANALYSIS AND EXPLORATORY META-REGRESSI…
2017
Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs)+/- 95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total …
Dianthus superbus as a critically endangered species in Latvia: evaluation of its growth conditions and conservation possibilities
2021
Abstract Dianthus superbus is one of the most endangered species in Latvia and is on the verge of local extinction. Therefore, the aim of this study was to inventory previously identified populations of D. superbus in Latvia and to develop activities to conserve this species in accordance with the results obtained in situ. Expeditions on 18 previously documented locations, according to the data of Nature Conservation Agency, revealed only three existing D. superbus localities in Latvia with a significant number of specimens located in the Latgale region near Silenieki. In 2020, for the first time, two more new D. superbus localities were found in the vicinity of these three approved locatio…
Observational constraints on the modelling of SN 1006
2011
The shape of the cutoff in the synchrotron emission of SN 1006 observed with XMM-Newton
2013
Synchrotron X-ray emission from the rims of young supernova remnants allows us to study the high-energy tail of the electrons accelerated at the shock front. The analysis of X-ray spectra can provide information on the physical mechanisms that limit the energy achieved by the electrons in the acceleration process. We aim at verifying whether the maximum electron energy in SN 1006 is limited by synchrotron losses and at obtaining information on the shape of the cutoff in the X-ray synchrotron emission. We analyzed the deep observations of the XMM-Newton SN 1006 Large Program. We performed spatially resolved spectral analysis of a set of small regions in the nonthermal limbs and studied the X…
Association of prestroke metformin use, stroke severity, and thrombolysis outcome
2020
ObjectiveTo evaluate whether pretreatment with metformin (MET) is associated with less stroke severity and better outcome after IV thrombolysis (IVT), we analyzed a cohort of 1,919 patients with stroke with type 2 diabetes mellitus in a multicenter exploratory analysis.MethodsData from patients with diabetes and ischemic stroke treated with IVT were collected within the European Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration. We applied propensity score matching (PSM) to obtain balanced baseline characteristics of patients treated with and without MET.ResultsOf 1,919 patients with stroke with type 2 diabetes who underwent IVT, 757 (39%) had received MET before stroke (MET+),…
Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Informatio…
2018
List of ACCIS contributors = Monika Hackl, Anna Zborovskaya, Nadya Dimitrova, Zdravka Valerianova, Ladislav Dušek, Margit Mägi, Alain Monnereau, Jacqueline Clavel, Michel Velten, Anne-Valérie Guizard, Véronique Bouvier, Xavier Troussard, Anne-Sophie Woronoff, Emilie Marrer, Brigitte Trétarre, Marc Colonna, Olivier Ganry, Pascale Grosclaude, Berndt Holleczek, Zsuzsanna Jakab, Laufey Tryggvadóttir, Lucia Mangone, Franco Merletti, Stefano Ferretti, Bianca Caruso, Maria Michiara, Rosario Tumino, Fabio Falcini, Roberto Zanetti, Giovanna Tagliabue, Otto Visser, Giske Ursin, Ryszard Mężyk, Kamila Kepska, José Laranja Pontes, Maja Primic Žakelj, Rafael Fernández-Delgado, Marisa L Vicente Raneda, En…
Modeling the shock-cloud interaction in SN 1006: unveiling the origin of nonthermal X-ray and gamma-ray emission
2016
The supernova remnant SN 1006 is a source of high-energy particles and its southwestern limb is interacting with a dense ambient cloud, thus being a promising region for gamma-ray hadronic emission. We aim at describing the physics and the nonthermal emission associated with the shock-cloud interaction to derive the physical parameters of the cloud (poorly constrained by the data analysis), to ascertain the origin of the observed spatial variations in the spectral properties of the X-ray synchrotron emission, and to predict spectral and morphological features of the resulting gamma-ray emission. We performed 3-D magnetohydrodynamic simulations modeling the evolution of SN 1006 and its inter…
Decreased Fibrogenesis After Treatment with Pirfenidone in a Newly Developed Mouse Model of Intestinal Fibrosis
2016
BACKGROUND Fibrosis as a common problem in patients with Crohn's disease is a result of an imbalance toward excessive tissue repair. At present, there is no specific treatment option. Pirfenidone is approved for the treatment of idiopathic pulmonary fibrosis with both antifibrotic and anti-inflammatory effects. We subsequently investigated the impact of pirfenidone treatment on development of fibrosis in a new mouse model of intestinal fibrosis. METHODS Small bowel resections from donor mice were transplanted subcutaneously into the neck of recipients. Animals received either pirfenidone (100 mg/kg, three times daily, orally) or vehicle. RESULTS After administration of pirfenidone, a signif…
The loss-limited electron energy in SN 1006: effects of the shock velocity and of the diffusion process
2013
The spectral shape of the synchrotron X-ray emission from SN 1006 reveals the fundamental role played by radiative losses in shaping the high-energy tail of the electron spectrum. We analyze data from the XMM-Newton SN 1006 Large Program and confirm that in both nonthermal limbs the loss-limited model correctly describes the observed spectra. We study the physical origin of the observed variations of the synchrotron cutoff energy across the shell. We investigate the role played by the shock velocity and by the electron gyrofactor. We found that the cutoff energy of the syncrotron X-ray emission reaches its maximum value in regions where the shock has experienced its highest average speed. T…