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RESEARCH PRODUCT
The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)
Fabio GirardiBrian RousCharles A StillerGemma GattaNaomi FershtHans H StormJessica R RodriguesChristian HerrmannRafael Marcos-grageraRafael Peris-bonetMikhail ValkovHannah K WeirRyan R WoodsHui YouPatricia A CuevaPrithwish DeVeronica Di CarloTom Børge JohannesenCarlos A LimaCharles F LynchMichel P ColemanClaudia AllemaniS BouzbidM ŠEkerijaC LewisConcord Working Groupsubject
AdultPediatricsmedicine.medical_specialtyCancer Researchepidemiological studypopulation-based cancer registriesDatabases FactualPopulationepidemiological study; health care disparities; histology; International Classification of Diseases; population-based cancer registries; primary brain tumorSocio-culturalehealth care disparitiesCancer registration610 Medicine & healthAstrocytomahistology03 medical and health sciencesGlobal population0302 clinical medicineInternational Classification of Diseasesepidemiological study health care disparities histology International Classification of Diseases population-based cancer registries primary brain tumormedicineHumans1306 Cancer ResearchRegistrieseducationChildMedulloblastomaprimary brain tumoreducation.field_of_studybusiness.industryBrain NeoplasmsAstrocytomaCancerHistology10060 Epidemiology Biostatistics and Prevention Institute (EBPI)medicine.diseaseEurope2728 Neurology (clinical)Oncology030220 oncology & carcinogenesisPopulation study2730 OncologyNeurology (clinical)business030217 neurology & neurosurgerydescription
Abstract Background Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. Methods The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014. Results Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults. Conclusions To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-19 |