Search results for "10a"
showing 10 items of 50 documents
Multi-parametric families solutions to the Burgers equation
2021
We construct 2N real parameter solutions to the Burgers' equation in terms of determinant of order N and we call these solutions, N order solutions. We deduce general expressions of these solutions in terms of exponentials and study the patterns of these solutions in functions of the parameters for N = 1 until N = 4.
Direct oral anticoagulant use in patients with thrombophilia, antiphospholipid syndrome or venous thrombosis of unusual sites: A narrative review.
2018
Direct oral anticoagulants (DOACs) are indicated in the treatment and prevention of venous thromboembolism (VTE). However, the use of DOACs in unusual VTE, including cerebral venous thrombosis (CVT) and splanchnic venous thrombosis (SVT), and in patients with biological thrombophilia including minor thrombophilia (Factor V Leiden and prothrombin G20210A), major innate thrombophilia (protein C and S deficiency, and antithrombin) and major acquired thrombophilia (antiphospholipid syndrome [APS]), remains controversial due to the paucity of available data. There are some reports of DOACs use in the initial treatment or long-term maintenance of patients with either CVT or SVT, but their efficac…
Inhibition of ovarian steroidogenesis by cyclic-GMP in a fly
2003
1479-6805 0022-0795; Previous investigations in the female blowfly Phormia regina have shown that 3-isobutyl-1-methylxanthine (IBMX), a broad spectrum inhibitor of phosphodiesterases (PDEs), fails to mimic the steroidogenic effects of cAMP on ovaries, although it efficiently increases the concentrations of this second messenger. In this study, experiments carried out to clear up this contradiction demonstrated that IBMX, besides its effect on cAMP, also increased cGMP concentrations in blowfly ovary and that these two cyclic nucleotides controlled ovarian steroidogenesis antagonistically. In particular, a selective inhibitor of cGMP-specific PDEs, unlike IBMX, had a very strong negative eff…
The phototransduction cascade in the isolated chick pineal gland revisited.
2003
It is well established that the isolated chick pineal gland is directly light sensitive and that melatonin synthesis of the gland can be inhibited by exposing the gland to light during scotophase. Since not all the steps of the phototransduction cascade have been clarified to the same extent as in the retina, we have treated isolated chick pineal glands with 90 min of light during scotophase and with drugs that affect key-components of vertebrate phototransduction, i.e., cyclic guanosine monophosphate (cGMP) phosphodiesterase 6 (PDE6), cGMP levels and cGMP-gated calcium channels. The endpoint measured was the activity of the rate-limiting enzyme of melatonin synthesis, arylalkylamine N-acet…
Comparación de las frecuencias de los alelos factor V Leiden (G1691A) y protrombina-G20210A entre pacientes con trombosis venosa profunda y población…
2006
Background: Factor V leiden and the -G20210A variant of prothrombin gene are associated to a higher risk of deep venous thrombosis. Aim: To assess the frequency of factor V Leiden (G1691A) and prothrombin -G20210A alleles in patients with deep venous thrombosis (DVT) and in the general population from Spain. Material and methods: Factor V Leiden (g1691a) and prothrombin-g20210a alleles were genotyped in 493 individuals from the Spanish general populations and in 131 patients with DVT. The presence of DVT was confirmed by phlebography. Allelic frequencies and the DVT risk associated with these variants were estimated. Results: Allelic frequencies for the factor V Leiden (G1691A) allele were …
Families of solutions to the KPI equation and the structure of their rational representations of order N
2018
We construct solutions to the Kadomtsev-Petviashvili equation (KPI) in terms of Fredholm determinants. We deduce solutions written as a quotient of wronskians of order 2N. These solutions called solutions of order N depend on 2N − 1 parameters. They can also be written as a quotient of two polynomials of degree 2N (N + 1) in x, y and t depending on 2N − 2 parameters. The maximum of the modulus of these solutions at order N is equal to 2(2N + 1) 2. We explicitly construct the expressions until the order 6 and we study the patterns of their modulus in the plane (x, y) and their evolution according to time and parameters.
8-parameter solutions of fifth order to the Johnson equation
2019
We give different representations of the solutions of the Johnson equation with parameters. First, an expression in terms of Fredholm determinants is given; we give also a representation of the solutions written as a quotient of wronskians of order 2N. These solutions of order N depend on 2N − 1 parameters. When one of these parameters tends to zero, we obtain N order rational solutions expressed as a quotient of two polyno-mials of degree 2N (N +1) in x, t and 4N (N +1) in y depending on 2N −2 parameters. Here, we explicitly construct the expressions of the rational solutions of order 5 depending on 8 real parameters and we study the patterns of their modulus in the plane (x, y) and their …
From first to fourth order rational solutions to the Boussinesq equation
2020
Rational solutions to the Boussinesq equation are constructed as a quotient of two polynomials in x and t. For each positive integer N , the numerator is a polynomial of degree N (N + 1) − 2 in x and t, while the denominator is a polynomial of degree N (N + 1) in x and t. So we obtain a hierarchy of rational solutions depending on an integer N called the order of the solution. We construct explicit expressions of these rational solutions for N = 1 to 4.
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
2019
A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…
First and second order rational solutions to the Johnson equation and rogue waves
2018
Rational solutions to the Johnson equation are constructed as a quotient of two polynomials in x, y and t depending on several real parameters. We obtain an infinite hierarchy of rational solutions written in terms of polynomials of degrees 2N (N + 1) in x, and t, 4N (N + 1) in y, depending on 2N − 2 real parameters for each positive integer N. We construct explicit expressions of the solutions in the cases N = 1 and N = 2 which are given in the following. We study the evolution of the solutions by constructing the patterns of their modulus in the (x, y) plane, and this for different values of parameters.