Search results for "120"

The state of the nursing science in Spain

2002

This article is giving a historical perspective of the nursing science in Spain, comparing it with the situation of the science, and nursing science at international level. The author gave a very clear description of the state of the art, and the nursing outcome shared by Spanish authors with the rest of nursing scientific community, arriving to the conclusion that Spanish nursing is at the beginning of a process where, negative factors can be clearly identified and, potential measures to improve relatively easily nursing science can be taken in the short term.

Nintedanib in non-small cell lung cancer: from preclinical to approval

2015

Angiogenesis is a driving force of a tumor’s development. Targeting this process is an attractive option, as this is a feature shared by most of the solid tumors. A lot of antiangiogenic drugs have been developed following this path, including bevacizumab, sorafenib, sunitinib, vandetanib, ramucirumab, motesanib and many others. The latest drug of this class to be approved for patients with non-small cell lung cancer (NSCLC) was nintedanib, a triple angiokinase inhibitor. This molecule targets vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and fibroblast growth factor (FGF) pathways, avoiding the tumor’s switch to normal escape mechanisms. The pharmacokine…

Hydrogen bonding patterns of 7,9-dimethylguanine and its transplatinum(II) complexes

2002

Methylation at the N7 position is one of the most frequently naturally occurring modifications of guanosine. This alteration drastically changes the hydrogen bonding and acid–base properties of the guanine nucleobase. Here we show on the example of the model nucleobase 7,9-dimethylguanine that due to blockage of N7 of the purine ring, new hydrogen bonding patterns occur on the minor groove binding face of this nucleobase involving the ring nitrogen N3 and the exocyclic amino group N2H2. The free 7,9-dimethylguaninium ion and several transplatinum(II) complexes of the this ligand are presented and discussed. Methylation at N7 drastically changes the acid–base and hydrogen bonding properties …

Effects of heavy barbell hip thrust vs back squat on subsequent sprint performance in rugby players

2020

The objective of this research was to compare the effect of Post-Activation Performance Enhancement (PAPE) exerted on the back squat (BS) versus the barbell hip thrust (HT) on the sprint performance (5- and 10-m). 17 male amateur rugby players participated in the study (age 22.14 ± 2.52 years; body mass 81.06 ± 9.6 kg; height 1.78 ± 0.05 m). All participants performed a dynamic maximum strength test (3RM) in BS and HT at maximum speed. Two randomized sessions were performed inducing PAPE using BS or HT trough three series with three repetitions at 85% 1RM eight minutes before the sprint tests. An ANOVA of repeated measurement, found no differences in the time for 5-m (F = 0.398, P = 0.537, …

Key Determinants of Team Success in Elite Men’s Wheelchair Basketball

Performance Analysis has become an integral part of the coaching process within elite wheelchair basketball, assisting staff with the delivery of augmented feedback (Fliess-Douer et al. 2016). Whilst previous attempts to explore the key determinants of success within wheelchair basketball have identified that stronger teams accumulate a greater number of assists, turnovers, free-throw and field goal shooting attempts (Gómez et al. 2015; Molik et al. 2009), the use of secondary box score data in such studies has been questioned for both its validity and reliability (Ziv et al. 2010). The purpose of this study, therefore, was to explore the key determinants of team success within elite men’s …

Weight cycling in combat sports: revisiting 25 years of scientific evidence

2021

Abstract Background As combat sports are classified by body mass, many athletes engage in rapid weight loss (RWL) prior to competition so they can gain an advantage over lighter opponents. Following the weigh-in, athletes engage in rapid weight gain (RWG), whereby some athletes have been able to compete up to three weight categories greater than the official division weighed in at. Results Although the impact of weight cycling on performance remains equivocal, robust scientific evidence indicates serious acute and chronic negative consequences on physiological and health-related parameters. Still, weight cycling remains highly prevalent in combat sports, and interventions to limit or stop t…

Viability and Stimulation of Human Stem Cells from the Apical Papilla (hSCAPs) Induced by Silicate-Based Materials for Their Potential Use in Regener…

2020

Blood clot formation in the apical third of the root canal system has been shown to promote further root development and reinforcement of dentinal walls by the deposition of mineralized tissue, resulting in an advancement from traditional apexification procedures to a regenerative endodontic treatment (RET) for non-vital immature permanent teeth. Silicate-based hydraulic biomaterials, categorized as bioactive endodontic cements, emerged as bright candidates for their use in RET as coronal barriers, sealing the previously induced blood clot scaffold. Human stem cells from the apical papilla (hSCAPs) surviving the infection may induce or at least be partially responsible for the regeneration …

Offensive and defensive team performance: relation to successful and unsuccessful participation in the 2010 Soccer World Cup

2013

Delgado-Bordonau, J.L., Domenech-Monforte, C., Guzman, J.F. & Mendez-Villanueva, A. (2013). Offensive and defensive team performance: relation to successful and unsuccessful participation in the 2010 Soccer World Cup. J. Hum. Sport Exerc., 8(4), pp.894-904. The present study was conducted to analyze the impact of selected offensive and defensive performance indicators in relation to teams’ success in the 2010 soccer World Cup. The sample used corresponded to 54 matches played in both the group and knockout stage. The game-related statistics gathered were: total shots, shots on goal, shots off goal, % of shots on goal from total shots, % of shots off goal from total shots, offensive and defe…

Effect of the pacing strategy during half-duration resistance test on the mechanic, metabolic and cardio-respiratory response

2017

Objective: Changes in pacing rhythm are translated into functional and metabolic changes that can be significantly reflected in the final results of an athlete. Method: Ten male subjects, with moderate performance level (age: 25.2 ± 2.2 years; VO2max: 56.9 ± 5.7 ml kgâ1 minâ1), performed four 5-min races with different pacing strategies: constant-pace (CP), record-pace (RP), kicker-pace (KP), incremental-pace (IP). Results: The cardio-respiratory response did not show statistically significant. There were statistically significant differences (p â¤Â 0.05) in the energetic efficiency among the protocols CP vs. RP, CP vs. KP and RP vs. IP. When results were analyzed by partials (1-m…

Comparative Cytocompatibility and Mineralization Potential of Bio-C Sealer and TotalFill BC Sealer

2019

The aim of this study was to investigate the cytocompatibility and mineralization potential of two premixed hydraulic endodontic sealers compared with an epoxy resin-based root canal sealer. The cellular responses and mineralization capacity were studied in human periodontal ligament stem cells (hPDLSCs) that were exposed to premixed hydraulic sealers, Bio-C Sealer (Angelus, Londr&iacute