Search results for "123"

showing 10 items of 133 documents

N-[2-(2,2-Di­methyl­propanamido)­pyrimidin-4-yl]-2,2-di­methyl­propanamide n-hexane 0.25-solvate hemihydrate

2013

The asymmetric unit of the title compound, C14H22N4O2·0.25C6H14·0.5H2O, contains two independent molecules of 2,4-bis(pivaloylamino)pyrimidine (M) with similar conformations, one water molecule and one-halfn-hexane solvent molecule situated on an inversion center. In one independentMmolecule, one of the twotert-butyl groups is rotationally disordered between two orientations in a 3:2 ratio. Then-hexane solvent molecule is disordered between two conformations in the same ratio. The water molecule bridges two independentMmoleculesviaO—H...O, N—H...O and O—H...N hydrogen bonds into a 2M·H2O unit, and these units are further linked by N—H...N hydrogen bonds into chains running in the [010] dire…

CrystallographyHydrogen bondHemihydrateGeneral Chemistrydata-to-parameter ratio = 14.2T = 123 KR factor = 0.079Condensed Matter PhysicsBioinformaticsPropanamideOrganic PapersSolventHexaneCrystallographychemistry.chemical_compoundwR factor = 0.164chemistryQD901-999mean σ(C–C) = 0.006 Åsingle-crystal X-ray studyGeneral Materials Scienceta116disorder in main residue
researchProduct

"Table 54" of "Tuning and test of fragmentation models based on identified particles and precision event shape data."

1996

XP distribution for DEL++ production.. Data read from plot.

DN/DXInclusiveE+ E- --> DELTA(1232P33)++ XE+ E- Scattering91.2Single Differential Distribution
researchProduct

Amphiphilic HPMA-LMA copolymers increase the transport of Rhodamine 123 across a BBB model without harming its barrier integrity.

2012

Abstract The successful non-invasive treatment of diseases associated with the central nervous system (CNS) is generally limited by poor brain permeability of various developed drugs. The blood–brain barrier (BBB) prevents the passage of therapeutics to their site of action. Polymeric drug delivery systems are promising solutions to effectively transport drugs into the brain. We recently showed that amphiphilic random copolymers based on the hydrophilic p(N-(2-hydroxypropyl)-methacrylamide), pHPMA, possessing randomly distributed hydrophobic p(laurylmethacrylate), pLMA, are able to mediate delivery of domperidone into the brain of mice in vivo. To gain further insight into structure–propert…

Drug CarriersPharmaceutical SciencePolymer architectureBiological TransportPharmacologyBlood–brain barrierRhodamine 123Models BiologicalPermeabilityCell Linechemistry.chemical_compoundmedicine.anatomical_structurechemistryTranscytosisIn vivoBlood-Brain BarrierNanoparticles for drug delivery to the brainAmphiphilemedicineHumansMethacrylatesRhodamine 123Barrier functionFluorescent DyesJournal of controlled release : official journal of the Controlled Release Society
researchProduct

"Table 40" of "Tuning and test of fragmentation models based on identified particles and precision event shape data."

1996

Compilation of multiplicities of baryons from current LEP I data.

E+ E- --> LAMBDA XE+ E- --> SIGMA(1385P13)- XE+ E- --> SIGMA(1385P13)+ XStrange productionNuclear TheoryHigh Energy Physics::PhenomenologyE+ E- --> OMEGA- X91.2Astrophysics::Cosmology and Extragalactic AstrophysicsE+ E- --> P XMULTInclusiveE+ E- --> XI(1530P13)0 XE+ E- --> DELTA(1232P33)++ XE+ E- ScatteringComputer Science::Programming LanguagesE+ E- --> XI- XHigh Energy Physics::ExperimentE+ E- --> LAMBDA/B0 X
researchProduct

Menopause and diabetes: EMAS clinical guide

2018

Abstract Introduction Whether menopause increases the risk of type 2 diabetes mellitus (T2DM) independently of ageing has been a matter of debate. Controversy also exists about the benefits and risks of menopausal hormone therapy (MHT) in women with T2DM. Aims To summarise the evidence on 1) the effect of menopause on metabolic parameters and the risk of T2DM, 2) the effect of T2DM on age at menopause, 3) the effect of MHT on the risk of T2DM, and 4) the management of postmenopausal women with T2DM. Materials and methods Literature review and consensus of experts’ opinions. Results and conclusion Metabolic changes during the menopausal transition include an increase in and the central redis…

ESTROGEN REPLACEMENTmedicine.medical_specialtyHORMONE-REPLACEMENT THERAPYendocrine system diseasesmedicine.medical_treatment030209 endocrinology & metabolismDiseaseDydrogesteroneGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicine3123 Gynaecology and paediatricsRisk FactorsInternal medicineDiabetes mellitusType 2 diabetes mellitusDiabetes MellitusmedicineHumansNATURAL MENOPAUSEMenopausal hormone therapy; Menopause; Type 2 diabetes mellitus; Estrogen Replacement Therapy; Female; Humans; Incidence; Risk Factors; Diabetes Mellitus Type 2; MenopauseESTRADIOLMETABOLIC SYNDROME030219 obstetrics & reproductive medicineProgestogenINSULIN SENSITIVITYbusiness.industryIncidenceEstrogen Replacement TherapyENERGY-EXPENDITUREnutritional and metabolic diseasesObstetrics and GynecologyType 2 Diabetes MellitusHormone replacement therapy (menopause)medicine.disease3. Good healthMenopausePOSTMENOPAUSAL WOMENDiabetes Mellitus Type 23121 General medicine internal medicine and other clinical medicineRISK-FACTORSFemaleHEALTHMenopauseMetabolic syndromebusinessType 2Menopausal hormone therapymedicine.drug
researchProduct

How do early family systems predict emotion recognition in middle childhood?

2021

Facial emotion recognition (FER) is a fundamental element in human interaction. It begins to develop soon after birth and is important in achieving developmental tasks of middle childhood, such as developing mutual friendships and acquiring social rules of peer groups. Despite its importance, FER research during middle childhood continues to be rather limited. Moreover, research is ambiguous on how the quality of one's early social-emotional environment shapes FER development, and longitudinal studies spanning from infancy to later development are scarce. In this study, we examine how the cohesive, authoritarian, disengaged and enmeshed family system types, assessed during pregnancy and inf…

EXPRESSIONSociology and Political Science515 Psychologylapset (ikäryhmät)sosiaalinen vuorovaikutusMiddle childhoodkehityspsykologia050105 experimental psychologymiddle childhoodDevelopmental psychologyCompetence (law)Person orientedkouluikäisettunteet3123 Gynaecology and paediatricsemotion recognitionDevelopmental and Educational Psychologyearly social-emotional environment0501 psychology and cognitive sciencesFamily systemsKNOWLEDGEEmotion recognitionsosiaalinen kehitysSocial informationlapsen kehitysperson-orientedCONFLICT05 social sciencesSOCIAL INFORMATIONCHILDRENS RECOGNITIONCOMPETENCEperhetaustaATTACHMENTMODELfamily systemExpression (architecture)perhesuhteetADOLESCENCEPsychologySocial Sciences (miscellaneous)BEHAVIOR050104 developmental & child psychologykasvontunnistus (kognitio)
researchProduct

Experimental Study of the Effects of EIPA, Losartan, and BQ-123 on Electrophysiological Changes Induced by Myocardial Stretch

2015

[ES] Introducción y objetivos Se han implicado diversos mecanismos en la respuesta mecánica al estiramiento miocárdico, que incluyen la activación del intercambiador Na+/H+ por acciones autocrinas y paracrinas. Se estudia la participación de estos mecanismos en las respuestas electrofisiológicas al estiramiento agudo miocárdico mediante el análisis de los cambios inducidos con fármacos. Métodos Se analizan las modificaciones de la fibrilación ventricular inducidas por el estiramiento agudo miocárdico en corazones de conejo aislados y perfundidos utilizando electrodos múltiples epicárdicos y técnicas cartográficas. Se estudian 4 series: control (n = 9); durante la perfusión del antagonista d…

Endothelin Receptor AntagonistsAngiotensin receptorINGENIERIA MECANICAArritmiaAngiotensin II receptor antagonistPharmacologyAmiloridechemistry.chemical_compoundReceptorBiomechanical stressMapeoDrugsHeartGeneral MedicineElectrophysiologyLosartanMappingFármacosCardiologyRabbitsmedicine.symptomEndothelin receptorPerfusionArrhythmiamedicine.drugmedicine.medical_specialtySodium-Hydrogen ExchangersPeptides CyclicLosartanEndothelinElectrofisiologíaTECNOLOGIA ELECTRONICAEndotelinaStress PhysiologicalInternal medicinemedicineEpithelial Sodium Channel BlockersAnimalsVentricular fibrillationFibrilación ventricularFibrillationBQ-123Investigación básicabusiness.industryMyocardiumInhibidores de la angiotensinachemistryAngiotensin inhibitorsMiocardioEstrés biomecánicombusinessBasic researchAngiotensin II Type 1 Receptor Blockers
researchProduct

Intravenous BQ-123 and phosphoramidon reduce ventricular ectopic beats and myocardial infarct size in dogs submitted to coronary occlusion and reperf…

2001

Abstract The aim of this work was to investigate the influence of endothelin on myocardial ischemia and reperfusion in anaesthetized dogs. Animals were submitted to left thoracotomy and 120 min of left anterior descending coronary occlusion, followed by 180 min of reperfusion. Arterial blood pressure and electrocardiogram (ECG) were recorded in order to analyze heart rate (HR)–pressure product and production of ectopic beats. Infarcted areas were identified by a macroscopic staining method and infarct size was expressed as percentage of risk zone. To inhibit the effects of endothelin in a group of animals, we administered intravenously an endothelin synthesis inhibitor (phosphoramidon) and …

Endothelin Receptor Antagonistsmedicine.medical_specialtyMyocardial InfarctionIschemiaBlood PressureCoronary DiseaseMyocardial ReperfusionPeptides Cyclicchemistry.chemical_compoundDogsInternal medicineHeart rateAnimalsMedicinecardiovascular diseasesMyocardial infarctionAntihypertensive AgentsPharmacologyBQ-123Endothelin-1Receptors Endothelinbusiness.industryPhosphoramidonGlycopeptidesReceptor Endothelin Amedicine.diseaseVentricular Premature ComplexesBlood pressurechemistryCoronary occlusionAnesthesiaInjections IntravenousVentricular Fibrillationcardiovascular systemCardiologyDrug Therapy CombinationbusinessEndothelin receptorGeneral Pharmacology: The Vascular System
researchProduct

Ottonis Episcopi Frisingensis ... Chronicon ... ; Eiusdem de gestis Friderici I ... Libri duo. Radeuici Frising. Canonici ... de eiusdem Frid. gestis…

Sig. *8, a-ff6, [creu llatina]8, A-S6 Capitals grav Reclams

Frederic I emperador romanogermànic ca. 1123-1190 Obres anteriors al 1800
researchProduct

Calcium in the prevention of postmenopausal osteoporosis: EMAS clinical guide

2017

Abstract Introduction Postmenopausal osteoporosis is a highly prevalent disease. Prevention through lifestyle measures includes an adequate calcium intake. Despite the guidance provided by scientific societies and governmental bodies worldwide, many issues remain unresolved. Aims To provide evidence regarding the impact of calcium intake on the prevention of postmenopausal osteoporosis and critically appraise current guidelines. Materials and methods Literature review and consensus of expert opinion. Results and conclusion The recommended daily intake of calcium varies between 700 and 1200 mg of elemental calcium, depending on the endorsing source. Although calcium can be derived either fro…

Genetics and Molecular Biology (all)OsteoporosisElemental calciumDiseaseDAIRY-PRODUCTSBiochemistrylaw.inventionCalcium; Diet; Excess-calcium risk; Postmenopausal osteoporosis; Prevention; Biochemistry Genetics and Molecular Biology (all); Obstetrics and GynecologyFractures Bone0302 clinical medicineRandomized controlled trial3123 Gynaecology and paediatricslawVITAMIN-D SUPPLEMENTATION030212 general & internal medicineVitamin DOsteoporosis PostmenopausalDIETARY CALCIUMObstetrics and GynecologyVitaminsRANDOMIZED CONTROLLED-TRIAL3. Good healthCARDIOVASCULAR-DISEASEDietary Reference IntakeFemalemedicine.medical_specialtychemistry.chemical_element030209 endocrinology & metabolismCalciumReference Daily IntakeGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesPostmenopausal osteoporosisInternal medicinemedicineVitamin D and neurologyHumansCORONARY-HEART-DISEASESYMPTOMATIC KIDNEY-STONESIntensive care medicinebusiness.industryPreventionSERUM-CALCIUMUPDATED METAANALYSISmedicine.diseaseFRACTURE PREVENTIONDietCalcium DietaryExcess-calcium riskEndocrinologychemistryDietary SupplementsOsteoporosisCalciumbusinessMaturitas
researchProduct