Search results for "129"
showing 10 items of 145 documents
El proyecto mapa escolar de Valencia: Análisis de la zonificación educativa de la ciudad de Valencia
2018
The research project Mapa Escolar de Valencia (School Map of Valencia) was born out of an agreement between the City Council and the University of Valencia in order to carry out an investigation of the compulsory education system of the city and propose, if necessary, modifications to the current school zoning. The project is structured in several research areas. An analysis of the specialized scientific literature and public policies concerning education and schooling has been done, and it is currently analysing the evolution of quantitative and qualitative data on compulsory schooling in Valencia, its school zoning, the representations of education and the school climate in the city schoo…
Innate Effector-Memory T-Cell Activation Regulates Post-Thrombotic Vein Wall Inflammation and Thrombus Resolution
2016
Rationale: Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. Objective: This study investigated the recruitment, activation, and inflammatory activity of T cells in deep vein thrombosis and its consequences for venous thrombus resolution. Methods and Results: CD4 + and CD8 + T cells infiltrate the thrombus and vein wall rapidly on deep vein thrombosis induction and remain in the tissue throughout the thrombus resolution. In the vein wall, recruited T cells largely consist of effect…
Comparative analysis of virtual screening approaches in the search for novel EphA2 receptor antagonists
2015
The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth. Recent medicinal chemistry efforts have identified bile acid derivatives as low micromolar binders of the EphA2 receptor. However, these compounds suffer from poor physicochemical properties, hampering their use in vivo. The identification of compounds able to disrupt the EphA2-ephrin-A1 complex lacking the bile acid scaffold may lead to new pharmacological tools suitable for in vivo studies. To identify the most promising virtual screening (VS) protocol aimed at finding novel EphA2 antagonists, we investigated the ability of…
Thy-1 (CD90) regulates the extravasation of leukocytes during inflammation.
2010
Human Thy-1 (CD90) has been shown to mediate adhesion of inflammatory cells to activated microvascular endothelial cells via interaction with Mac-1 (CD11b/CD18) in vitro. Since there are no data showing the physiological relevance of Thy-1 for the recruitment of inflammatory cells in vivo, different inflammation models were investigated in Thy-1-deficient mice and littermate controls. In thioglycollate-induced peritonitis, the number of neutrophils and monocytes was significantly diminished in Thy-1-deficient mice. During acute lung inflammation, the extravasation of eosinophils and monocytes into the lung was significantly reduced in Thy-1-deficient mice. Moreover, during chronic lung infl…
Habilitats de visualització manifestades per alumnes de primària quan resolen activitats de geometria 3D i la seua relació amb el talent matemàtic
2016
Aquesta investigació ha estat motivada per la importància de la visualització per comprendre millor el món que ens envolta, fet que contrasta amb la realitat a l’escola, on no se li dóna la consideració necessària. D’altra banda, també ens han preocupat els alumnes amb talent matemàtic, ja que reben una atenció molt deficient en les aules ordinàries. En aquest sentit, aquesta investigació té per objectius generals oferir un material educatiu caracteritzat per l’ús de diferents materials manipulatius que ajuden a l’alumnat amb diferents graus de talent matemàtic a manifestar les seues habilitats de visualització (Del Grande, 1990) i característiques de talent matemàtic. Els objectius concret…
Fundamentals of Paleoimaging Techniques: Bridging the Gap Between Physicists and Paleopathologists
2011
Propuesta metodológica para el diagnóstico del autobús urbano en ciudades medias-pequeñas
2016
Supplementary_Material – Supplemental material for Clinical response to linaclotide at week 4 predicts sustained response in irritable bowel syndrome…
2019
Supplemental material, Supplementary_Material for Clinical response to linaclotide at week 4 predicts sustained response in irritable bowel syndrome with constipation and improvements in digestive and extra-digestive symptoms by Blanca Serrano-Falcón, Sílvia Delgado-Aros, Fermín Mearin, Constanza Ciriza de los Ríos, Jordi Serra, Miguel Mínguez, Miguel Montoro Huguet, Antonia Perelló, Cecilio Santander, Ángeles Pérez Aisa, Inmaculada Bañón-Rodríguez and Enrique Rey in Therapeutic Advances in Gastroenterology
Supplemental material for Quantitative and qualitative control of antineoplastic preparations: Gravimetry versus HPLC
2019
Supplemental Material for Quantitative and qualitative control of antineoplastic preparations: Gravimetry versus HPLC by Ana Sendra-García, M Amparo Martínez-Gómez, Asunción Albert-Marí, N Victor Jiménez-Torres and Mónica Climente-Martí in Journal of Oncology Pharmacy Practice
sj-pdf-1-opp-10.1177_1078155220915763 - Supplemental material for Clinical and economic impact of pharmacist interventions in an ambulatory hematolog…
2020
Supplemental material, sj-pdf-1-opp-10.1177_1078155220915763 for Clinical and economic impact of pharmacist interventions in an ambulatory hematology–oncology department by Jonathan de Grégori, Pauline Pistre, Meredith Boutet, Laura Porcher, Madeline Devaux, Corinne Pernot, Marie L Chrétien, Cédric Rossi, Sylvain Manfredi, Sophie Dalac, Pauline Gueneau and Mathieu Boulin in Journal of Oncology Pharmacy Practice