Search results for "16."
showing 10 items of 7809 documents
CCDC 973532: Experimental Crystal Structure Determination
2014
Related Article: Ludovico G. Tulli, Negar Moridi, Wenjie Wang, Kaisa Helttunen, Markus Neuburger, David Vaknin, Wolfgang Meier, Patrick Shahgaldian|2014|Chem.Commun.|50|3938|doi:10.1039/C4CC00928B
205th ENMC International Workshop: Pathology diagnosis of idiopathic inflammatory myopathies Part II 28-30 March 2014, Naarden, The Netherlands.
2015
The idiopathic inflammatory myopathies (IM) are a heterogeneous group of diseases and diagnosis often necessitates a muscle biopsy. Five main entities are recognized: (1) dermatomyositis (DM); (2) polymyositis (PM); (3) necrotizing autoimmune myopathy (NAM); (4) sporadic inclusion body myositis (IBM); and (5) non-specific myositis. Other entities include granulomatous myopathy, macrophagic myofasciitis, and eosinophilic fasciitis (Shulman's syndrome). The pathological classification and subsequent identification of disease subgroups are extremely important for assessing treatment options and prognosis in the individual patient, yet classification criteria have not been standardized and vali…
Meta-analysis of real-time fMRI neurofeedback studies using individual participant data: How is brain regulation mediated?
2015
An increasing number of studies using real-time fMRI neurofeedback have demonstrated that successful regulation of neural activity is possible in various brain regions. Since these studies focused on the regulated region(s), little is known about the target-independent mechanisms associated with neurofeedback-guided control of brain activation, i.e. the regulating network. While the specificity of the activation during self-regulation is an important factor, no study has effectively determined the network involved in self-regulation in general. In an effort to detect regions that are responsible for the act of brain regulation, we performed a post-hoc analysis of data involving different ta…
Baltu filoloģija, 23. sēj., Nr.1
2014
Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration
2021
Abstract Over the last two decades, misuse of 4-fluoroamphetamine (4-FA) became an emerging issue in many European countries. Stimulating effects last for 4–6 hours and can impact psychomotor performance. The metabolism of amphetamine-type stimulants is stereoselective and quantification of (R)- and (S)-enantiomers has been suggested for assessing time of use. To date, no data on enantioselective pharmacokinetics is available for 4-FA in serum samples. An enantioselective liquid chromatography−tandem mass spectrometry (LC–MS-MS) method was developed using a chiral Phenomenex® Lux 3 μm AMP column. Validation of the method showed satisfactory selectivity, sensitivity, linearity (0.5–250 ng/mL…
Steroidirungon synteesimenetelmät ja 3-metoksi-15,16-dehydroestronin stereoselektiivinen synteesi
2017
Tutkielman kirjallisessa osiossa käsitellään steroidirungon eri synteesimenetelmiä. Synteesimenetelmät esitellään niiden synteesistrategioiden mukaan, jotka on edelleen jaoteltu niissä esiintyvien reaktioiden tai yleisten lähtöaineiden pohjalta. Johdannossa käydään lyhyesti läpi steroidien rakenne ja niiden biosynteesi ihmisen elimistössä. Tämän jälkeen aloitetaan synteesien tarkastelu sekosteroidi välivaiheisiin pohjautuvista eli steroidirungon keskiosan rakentamiseen keskittyvistä synteesistrategioista, joista siirrytään steroidirungon renkaat järjestyksessä rakentaviin synteeseihin. Näiden synteesien jälkeen palataan luonnonmukaisempaan steroidien synteesitapaan eli polysyklisaatioon. Lo…
Exosome levels in human body fluids: A tumor marker by themselves?
2016
Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discrimin…
Development of a simple, biocompatible and cost-effective Inulin-Diethylenetriamine based siRNA delivery system
2015
Small interfering RNAs (siRNAs) have the potential to be of therapeutic value for many human diseases. So far, however, a serious obstacle to their therapeutic use is represented by the absence of appropriate delivery systems able to protect them from degradation and to allow an efficient cellular uptake. In this work we developed a siRNA delivery system based on inulin (Inu), an abundant and natural polysaccharide. Inu was functionalized via the conjugation with diethylenetriamine (DETA) residues to form the complex Inu-DETA. We studied the size, surface charge and the shape of the Inu-DETA/siRNA complexes; additionally, the cytotoxicity, the silencing efficacy and the cell uptake-mechanis…
Spiking Neural Networks models targeted for implementation on Reconfigurable Hardware
2017
La tesis presentada se centra en la denominada tercera generación de redes neuronales artificiales, las Redes Neuronales Spiking (SNN) también llamadas ‘de espigas’ o ‘de eventos’. Este campo de investigación se convirtió en un tema popular e importante en la última década debido al progreso de la neurociencia computacional. Las Redes Neuronales Spiking, que tienen no sólo la plasticidad espacial sino también temporal, ofrecen una alternativa prometedora a las redes neuronales artificiales clásicas (ANN) y están más cerca de la operación real de las neuronas biológicas ya que la información se codifica y transmite usando múltiples espigas o eventos en forma de trenes de pulsos. Este campo h…
La mediación en el ámbito educativo en España. Estudio comparado entre comunidades autónomas
2011
El presente trabajo, La mediación en el ámbito educativo en España. Estudio comparado entre comunidades autónomas, se divide en dos partes claramente diferenciadas. La primera parte, de carácter teórico, está dirigida a exponer los fundamentos conceptuales que están en la base de la mediación como proceso de resolución de conflictos en cualquier ámbito, así como a reflexionar, más concretamente, acerca del uso de la mediación en el ámbito educativo español. Así pues, se presenta una aproximación a su origen, a su concepto, a sus ámbitos de aplicación, a sus características esenciales, a los diferentes modelos o escuelas de mediación, a la mediación entendida como proceso, a la figura de la …