Search results for "16."

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.

2011

Background: Cannabinoids are known to reduce intestinal inflammation. Atypical cannabinoids produce pharmacological effects via unidentified targets. We were interested in whether the atypical cannabinoid O-1602, reportedly an agonist of the putative cannabinoid receptor GPR55, reduces disease severity of dextran sulfate sodium (DSS) and trinitrobenzene sulfonic acid (TNBS)-induced colitis in C57BL/6N and CD1 mice. Methods: DSS (2.5% and 4%) was supplied in drinking water for 1 week while TNBS (4 mg) was applied as a single intrarectal bolus. Results: Both treatments caused severe colitis. Injection of O-1602 (5 mg/kg intraperitoneally) significantly reduced macroscopic and histological col…

Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism

2012

N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…

Humane Orientation as a New Cultural Dimension of the GLOBE Project: A Validation Study of the GLOBE Scale and Out-Group Humane Orientation in 25 Cou…

2013

SCHLÖSSER, Oliver; HEINTZE, Anna-Maria; AL-NAJJAR, Musaed; ARCISZEWSKI, Thomas; BESEVEGIS, Elias; BISHOP, George David; BONNES, Mirilia; CLEGG, Chris W.; DROZDA-SENKOWSKA, Ewa; GABORIT, Mauricio; GARZON, Dayra; HANSEN, Tia G. B.; HESZEN, Irena; JUHASZ, Marta; KEATING, Mary A.; MANGUNDJAYA, Wustari; MANSOR, Norma; MITCHELSON, Jacqueline K.; ORTIZ-REYNOSO, Alejandra; PANDEY, Janak; PAVAKANUN, Ubolwanna; PAVLOPOULOS, Vassilis; PEIRO, Jose M.; POTOCNIK, Kristina; RESTREPO-ESPINOSA, Maria H.; SEMMER, Norbert; TUPINAMBA, Antonio Caubi Ribeiro; VENTURA, Elizabeth R.; WHOOLERY, Matthew; ZHANG, Kan. Humane orientation as a new cultural dimension of the globe project: a validation study of the globe …

Integration of personality constructs: The role of traits and motivation in the willingness to exert effort in academic and social life domains

2014

There has been growing interest in recent years in exploring different types of personality constructs and the nature of inter-relationships between personality variables in predicting outcomes in different life domains. The present study explores how personality traits and autonomous goal motivation predict the willingness to invest effort in academic and social life domains. Using a sample of 4133 upper secondary school students in Germany, multilevel regression analyses yielded three main results. First, both personality traits and motivation were substantially related to the willingness to exert effort. Second, the mediation effect compared to the direct effect was relatively small. Thi…

Personality and Turnout: Results from the Finnish Longitudinal Studies

2011

Scholars in the field of electoral participation have for long been aware that turnout is strongly connected to sociopsychological variables such as religiosity, party identification, political interest and sense of political efficacy. The impact of personality characteristics has remained largely unexplored until recently. Based on the Jyvaskyla Longitudinal Study of Personality and Social Development (JYLS, original N = 369), this article analyses the links between individuals' personality traits and their propensity to vote at ages 36, 42 and 50. The personality traits are measured by using the five-factor model of personality consisting of extraversion, agreeableness, conscientiousness,…

Benchmarking of airports service quality by a new fuzzy MCDM approach

2015

Recent approaches to the service quality evaluation problem are focused on the employment of multi-criteria decisionmaking (MCDM) procedures, since processes related to service quality evaluation presentmeaningful communality elements to MCDM ones. Based on such assumption, in the present paper a new fuzzy MCDMapproach is developed tocomparatively evaluate passenger service quality of the international airports inSicily (Italy). In particular, by incorporating the respondents confidence level and degree of optimism on fuzzy assessments, quality scores of main airport service criteria are estimated, whereas ELECTRE multi criteria decision support methodis proposed to point out theservices qu…

Zvaigžņotā Debess: 2017, Pavasaris (235)

2017

Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: E.Mūkins. Clouds of Venus: Structure and Composition (abridged) ; J.Miezis. 3rd All-union Young Astronomers Gathering (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. New Discoveries in the Milky Way ; DISCOVERIES: I.Eglītis. Small Planets Get Latvian Names ; I.Pundure. Earth-mass World Revealed around Proxima Centauri ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. Mysteries of Saturn’s Clouds ; A.Slavinskis. Contribution of Estonian Student Satellite Programme ESTCube to Largest Challenges for Humanity ; R.Misa. Impossible Engine that Is likely Possible ; I.Pundure. ESO VLT to Search for Planets in Alpha Centauri System ; EARTH and COSMOS: J.…

Selective recovery of phosphorus as AlPO4 from silicon-free CFB-derived fly ash leachate

2018

The prospect of phosphorus (P) recovery from siliceous fly ash was investigated. The phosphorus content in the pristine fly ash was 1.21%. Obtaining pure phosphorus products from fly ash is very challenging because of high concentration of other elements, silicon (Si) at 17.3% being the major contaminant. The fly ash was fractionated with sieve size of 125 μm to concentrate the phosphorus in the small-size fraction, which also facilitated the removal of 78% of silica (Si) in the solid phase. The fractionated fly ash was treated with 8 M HCl in order to remove 98% of Si by aging (5 h) of leachate until precipitation of Si-gel, and a phosphorus-rich solution is obtained. Iron (Fe) is also con…

Recio Morales, Oscar: Alejandro O'Reilly, inspector general. Poder militar, familia y territorio en el reinado de Carlos III

2021

El uso y consumo de agua en los jardines de las viviendas del litoral de Alicante (España)

2016

El jardín es el elemento que ha adquirido una mayor difusión en los modelos urbanos extensivos en la costa de Alicante (España). En este territorio, a diferencia de otros ámbitos, los jardines unifamiliares se asocian a las urbanizaciones que se han ido configurando desde 1960 a raíz de la expansión del denominado turismo residencial. Los objetivos de esta investigación son identificar las principales características de los jardines unifamiliares y, a partir de ellas, estimar sus necesidades hídricas y determinar el volumen de agua doméstico consumido por el jardín en el hogar. Profundizar en estos factores resulta prioritario para determinar sus repercusiones en la demanda de agua presente…