Search results for "2-3"

Izglītības vide 2-3 gadu vecu bērnu kritiskās domāšanas attīstībai

2021

Diplomdarba temats: Izglītības vide 2-3 gadu vecu bērnu kritiskās domāšanas attīstībai. Autore: Iveta Griķe. Diplomdarba apjoms: 97.lappuses, iekļautas 15 tabulas, 9 attēli, izmantots 61 literatūras avots latviešu, angļu, vācu un krievu valodā, pievienoti 2 pielikumi. Pētījuma mērķis: Izpētīt izglītības vidi 2-3gadu vecu bērnu kritiskās domāšanas attīstībai pirmsskolas izglītības iestādē. Teorētiskajā daļā analizēta pedagoģiskā un psiholoģiskā lieteratūta par 2-3 gadu vecu bērnu vecumposma raksturojumu, kritiskās domāšanas attīstību un izglītības vidi pirmsskolas izglītības iestādē. Praktiskajā daļā analizēta skolotāju pedagoģiskā pieredze tādas izglītības vides veidošanā, kas veicina 2-3 g…

Volatiles in pantellerite magmas: A case study of the Green Tuff Plinian eruption (Island of Pantelleria, Italy)

2013

Abstract The Green Tuff (GT) Plinian eruption, the largest in magnitude at Pantelleria, erupted 3 to 7 km3 DRE of pantellerite magma and a small volume of trachyte. Fifty-nine anorthoclase-hosted melt inclusions from the two basal pumice members were analyzed by FT-IR spectroscopy in order to assess the pre-eruptive H2O content in the pantellerite melt. Microanalytical methods were used to determine major element, Cl, F and S contents. Melt inclusions and glassy groundmasses have a nearly homogeneous pantelleritic composition (peralkaline index = 1.9-2.2) and variable water contents ranging from 1.4 to as high as 4.2 wt %, i.e. much higher than the 1.4 wt % of earlier published studies. The…

Spectral analysis and orbital evolution of Low Mass X-ray Binaries at high inclination

X-Ray binaries are gravitationally bound systems consisting of a compact object that accretes matter from a companion star; they are the most interesting objects of the sky, infact they allow to study the physics of matter in very extreme conditions of density, temperature or magnetic eld. So the determination of spectral and temporal properties of X-ray binaries plays an important role in understanding the processes involved in these systems. This project aims to understand the properties of binary systems, at high inclination (dipping and eclips- ing sources), containing neutron stars weakly magnetized. In the light curves of these systems it is possible to identify a variety of modulatio…

A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages

2013

AbstractThe differentiation of human peripheral blood monocytes into macrophages can be reproduced ex vivo by culturing the cells in the presence of colony-stimulating factor 1 (CSF1). Using microarray profiling to explore the role of microRNAs (miRNAs), we identified a dramatic decrease in the expression of the hematopoietic specific miR-142-3p. Up- and down-regulation of this miRNA in primary human monocytes altered CSF1-induced differentiation of monocytes, as demonstrated by changes in the expression of the cell surface markers CD16 and CD163. One of the genes whose expression is repressed by miR-142-3p encodes the transcription factor Early Growth Response 2 (Egr2). In turn, Egr2 assoc…

Increases in Plasma Tryptophan Are Inversely Associated with Incident Cardiovascular Disease in the Prevención con Dieta Mediterránea (PREDIMED) Stud…

2017

Background: During development of cardiovascular disease (CVD), interferon-γ-mediated inflammation accelerates degradation of tryptophan into downstream metabolites. A Mediterranean diet (MedDiet) consisting of a high intake of extra-virgin olive oil (EVOO), nuts, fruits, vegetables, and cereals has been demonstrated to lower the risk of CVD. The longitudinal relation between tryptophan and its downstream metabolites and CVD in the context of a MedDiet is unstudied.Objective: We sought to investigate the relation between metabolites in the tryptophan-kynurenine pathway and CVD in the context of a MedDiet pattern.Methods: We used a case-cohort design nested in the Prevención con Dieta Medite…

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions : a study on postmenopausal mo…

2014

MiRNAs are fine-tuning modifiers of skeletal muscle regulation, but knowledge of their hormonal control is lacking. We used a co-twin case-control study design, that is, monozygotic postmenopausal twin pairs discordant for estrogen-based hormone replacement therapy (HRT) to explore estrogen-dependent skeletal muscle regulation via miRNAs. MiRNA profiles were determined from vastus lateralis muscle of nine healthy 54-62-years-old monozygotic female twin pairs discordant for HRT (median 7 years). MCF-7 cells, human myoblast cultures and mouse muscle experiments were used to confirm estrogen's causal role on the expression of specific miRNAs, their target mRNAs and proteins and finally the act…

Dietary intake of vitamin K is inversely associated with mortality risk

2014

Vitamin K has been related to cardiovascular disease and cancer risk. However, data on total mortality are scarce. The aimof the present study was to assess the association between the dietary intake of different types of vitamin K and mortality in a Mediterranean population at high cardiovascular disease risk. A prospective cohort analysis was conducted in 7216 participants from the PREDIMED (Prevención con Dieta Mediterránea) study (median follow-up of 4.8 y). Energy and nutrient intakes were evaluated using a validated 137-item food frequency questionnaire. Dietary vitamin K intake was calculated annually using the USDA food composition database and other published sources. Deaths were a…

2 – 3 gadu vecu bērnu matemātisko priekšstatu apguves veicināšana Redžio Emilia pieejā

2019

Darba autorsEleonora Martina Floresa Darba nosaukums2 – 3 gadu vecu bērnu matemātisko priekšstatu apguves veicināšana Redžio Emilia pieejā MērķisIzpētīt kā 2 – 3 gadu vecu bērnu vidū Redžio Emilia pieejā tiek veicināti matemātiskie priekšstati. Apjoms57 lappuses, 42 attēli, 7 tabulas. StruktūraDarbs veidots no ievada, 2 nodaļām, 5 apakšnodaļām, secinājumiem, izmantotās literatūras un avotu saraksta ar 41 vienību, 5 pielikumiem. SatursPirmajā nodaļā tiek aprakstīti darba teorētiskie aspekti – kas ir Redžio Emilio pieeja, kas ir matemātiskās prasmes (priekšstati) un kā matemātiskās prasmes tiek veicinātas Redžio Emilio pieejā. Otrajā nodaļā aprakstīts praktiskais pētījums, ko autore ir viena …

The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

1999

The hepatitis C virus (HCV) is a major causative agent of transfusion-acquired and sporadic non-A, non-B hepatitis worldwide. Infections most often persist and lead, in approximately 50% of all patients, to chronic liver disease. As is characteristic for a member of the family Flaviviridae, HCV has a plus-strand RNA genome encoding a polyprotein, which is cleaved co- and post-translationally into at least 10 different products. These cleavages are mediated, among others, by a virally encoded chymotrypsin-like serine proteinase located in the N-terminal domain of non-structural protein 3 (NS3). Activity of this enzyme requires NS4A, a 54-residue polyprotein cleavage product, to form a stable…

Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway.

2001

Hepatitis C virus (HCV) persists in the majority of infected individuals and is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Chronic hepatitis C is currently treated with interferon (IFN)-α or with a combination of IFN-α and ribavirin. The availability of an HCV replicon system (Lohmann et al., Science 285, 110–113, 1999) allowed the investigation of the effects of IFN on genuine HCV replication in cultured cells. It is shown here that IFN-α inhibits subgenomic HCV RNA replication in HuH-7 human hepatoma cells. Immunofluorescence, Western blot and Northern blot analysis revealed that levels of both HCV protein and replicon RNA were reduced after treatme…