Search results for "2019"
showing 10 items of 1190 documents
Towards a European strategy to address the COVID-19 pandemic
2021
GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults
2022
International audience; Safe and effective vaccines against coronavirus disease 2019 (COVID-19) are essential for ending the ongoing pandemic. Although impressive progress has been made with several COVID-19 vaccines already approved, it is clear that those developed so far cannot meet the global vaccine demand alone. We describe a COVID-19 vaccine based on a replication-defective gorilla adenovirus expressing the stabilized prefusion severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein named GRAd-COV2. We assessed the safety and immunogenicity of a single-dose regimen of this vaccine in healthy younger and older adults to select the appropriate dose for each age group…
How the coronavirus pandemic has affected the clinical management of Philadelphia-negative chronic myeloproliferative neoplasms in Italy—a GIMEMA MPN…
2020
Since early 2020, the SARS-CoV-2 pandemic has a massive impact on health care systems worldwide. Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. Here, we provide recommendations for the management of patients with malignant disease in the times of COVID-19. These recommendations were prepared by an international panel of experts and then consented by the EHA Scientific Working Group on Infection in Hematology. The primary aim is to enable clinicians to provide optimal cancer care as safely…
Effects of the coronavirus disease 2019 pandemic on the number of hospitalizations for myocardial infarction: regional differences. Population analys…
2020
COVID-19 and economy.
2020
Testing & Opening in Augustusburg A Success Story?
2021
AbstractThe city of Augustusburg allowed for opening of, inter alia, restaurants and hotels joint with large-scale testing. We evaluate this testing & opening (T&O) experiment by comparing the evolution of case rates in Augustusburg with the evolution in other communities of Saxony. We have access to small-scale SARS-CoV-2 infection data at the community level (” Gemeinde”) instead of the county level (” Landkreis”) usually used for disease surveillance. Despite data challenges, we conclude that T&O did not lead to any increase in case rates in Augustusburg compared to its control county. When we measure the effect of T&O on cumulative cases, we find a small increase in Augu…
Mpro-SARS-CoV-2 Inhibitors and Various Chemical Reactivity of 1-Bromo- and 1-Chloro-4-vinylbenzene in [3 + 2] Cycloaddition Reactions
2021
The regioselectvity and the mechanism of the (32CA) cycloadditions reactions of 1-bromo-4-vinylbenzene 1 and 1-chloro-4-vinylbenzene 2 with benzonitrile oxide 3 were investigated under the molecular electron density theory (MEDT) at the B3LYP/6-311++G(d,p) computational level. Evaluation of the ELF reveals that these zwitterionic type (zw-type) 32CA reactions take place in a two-stage one-step mechanism. This MEDT study shows that the meta isoxazolines are kinetically and thermodynamically favored over the ortho ones, these 32CA reactions being completely regioselective, in agreement with experimental outcomes. In addition, the efficiency of isoxazolines against SARS-CoV-2 have been also in…
The first COVID-19 lockdown reveals an ambivalent relation of French parents with food pleasure: the struggle to find a balance
2021
International audience; In France, a first COVID-19 lockdown took place from March-May 2020. Using an online survey including three open-ended questions, this study explored parents' experiences regarding changes in their family's eating behaviors during this lockdown. French parents (n = 498, 71% mothers) of young children were invited to describe which food-related changes they (1) perceived as positive during the lockdown, (2) perceived as negative, and (3) would like to maintain after the lockdown. A thematic analysis revealed that parents appreciated the choice of more local, fresh and high-quality foods, the time to prepare foods (homemade dishes, new recipes) and cooking and eating w…
Effects of Coronavirus Disease 2019 (COVID-19) on Family Functioning
2021
More than a year and a half after the first clinical manifestations of coronavirus disease 2019 (COVID-19) were reported in Wuhan, China,1 , 2 the magnitude of the pandemic across the globe and its related clinical and social effects3 remain unclear.4 The pandemic has affected lives and sparked concerns about everything from health to job security. In high–Gross Domestic Product (GDP) countries, despite trillions in coronavirus aid released by governments, many families still struggle to pay for basic necessities like food and rent, and these difficulties worsened during the pandemic.5 , 6 The general social uncertainty caused by the pandemic seems to have also affected family resilience, w…
ARIA���EAACI statement on asthma and COVID���19 (June 2, 2020)
2021
Artículo con numerosos autores sólo se mencionan el primero y el de la UAM