Search results for "21st century"
showing 10 items of 103 documents
Alzheimer: A Decade of Drug Design. Why Molecular Topology can be an Extra Edge?
2017
Background The last decade was characterized by a growing awareness about the severity of dementia in the field of age-related and no age-related diseases and about the importance to invest resources in the research of new, effective treatments. Among the dementias, Alzheimer's plays a substantial role because of its extremely high incidence and fatality. Several pharmacological strategies have been tried but still now, Alzheimer keeps being an untreatable disease. In literature, the number of QSAR related drug design attempts about new treatments for Alzheimer is huge, but only few results can be considered noteworthy. Providing a detailed analysis of the actual situation and reporting the…
The Hammerhead Ribozyme: A Long History for a Short RNA
2017
Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner. The hammerhead ribozyme was the first reported and the most extensively studied member of this family. However, and despite intense biochemical and structural research for three decades since its discovery, the history of this model ribozyme seems to be far from finished. The hammerhead ribozyme has been regarded as a biological oddity typical of small circular RNA pathogens of plants. More recently, numerous and new variations of this ribozyme have been found to inhabit the genomes of organisms from all life kingdoms, although th…
Treatment of non-metastatic castration resistant prostate cancer in 2020: What is the best?
2020
Lately the development of 3 novel second-generation androgen receptor antagonists (enzalutamide, apalutamide, and darolutamide) chanced the treatment landscape of nonmetastatic castration-resistant prostate cancer. After proofing their clinical efficacy in large phase III registration trials with good compatibilities and tolerable side effects currently all 3 substances are Food and Drug Administration-approved in nonmetastatic castration-resistant prostate cancer. The present short review article provides an overview about these new treatment options and discusses their use in daily routine focusing on patient selection as well as on the impact of novel sensitive imaging modalities like pr…
Evaluation of historical atmospheric pollution in an industrial area by dendrochemical approaches
2019
International audience; We conducted a dendrochemical study in order to evaluate the exposure of territories and 19 populations to different types of pollutants and to characterise the history of pollution in one of the 20 most intensely industrialised areas of Europe: the industrial port zone of Fos, also heavily 21 urbanised. 22 To perform the study, two tree species have been selected, Pinus halepensis and Populus nigra, on arural plot located roughly 20 km away from the industrial harbor, an urban plot located in the city of Fos-sur-Mer and an industrial plot. Our study indicated that poplar was a more relevant model forthe dendrochemical studies exhibiting a higher bioaccumulation capa…
Performance Assessment of Generic and Domain-Specific Skills in Higher Education Economics
2020
Following criticisms by employers about academic graduates’ lack of 21st century skills, students need to develop skills such as professional knowledge, critical thinking and problem solving. Accordingly, there is a demand for suitable assessments of these skills. One approach is to develop a performance assessment using tasks adapted from real-world decision-making and judgment situations that students and graduates have to face in academic and professional domains. Such tasks employ real-life scenarios and require generic and domain-specific skills in different facets to handle a given problem adequately. In this paper, we present a newly developed performance assessment that aims to meas…
Evgeny Nikolaevich Sokolov (1920-2008).
2008
Group psychotherapy in Italy
2015
This article describes the history and the prevailing orientations of group psychotherapy in Italy (psychoanalytically oriented, psychodrama, CBT groups) and particularly group analysis. Provided free of charge by the Italian health system, group psychotherapy is growing, but its expansion is patchy. The main pathways of Italian training in the different group psychotherapy orientations are also presented. Clinical-theoretical elaboration on self development, psychopathology related to group experiences, and the methodological attention paid to objectives and methods in different clinical groups are issues related to group therapy in Italy. Difficulties in the relationship between research …
INTERPRETING LARGE SCALE NATIONAL LEVEL ASSESSMENT DATA IN MATHEMATICS BY USING RASCH ANALYSIS
2020
Latvia is undergoing a nation-wide curriculum reform in general education, with an aim to help students to develop 21st century skills. In order to successfully implement reform, not only teacher performance in the classroom is important, but also the transformation of the school culture is of high priority. One of the key dimensions that is characteristic for a school as learning organization culture is whether it has data-driven culture and is using data on continuous basis to improve student achievement. Large scale national level assessment data is used for many different purposes, however, this data only rarely is recognised as useful data source for planning actions to improve student…
Introducing Assessment Tools for 21st Century Skills in Finland
2014
The Finnish national interest in the enhancement of 21st century skills has highlighted a need for and interest in developing tools and methods for teaching and assessing such skills. In this chapter, we present and analyze the development process of online assessment tools in the Assessment and Teaching of 21st Century Skills study (ATC21STM) from the Finnish perspective. (The acronym ATC21STM has been globally trademarked. For purposes of simplicity the acronym is presented throughout the chapter as ATC21S.) The development process was implemented according to the guidelines of the international project through four phases, namely concept checks, cognitive laboratories, pilot studies and …
Costruire apprendimento e partecipazione a scuola:da studenti unteachables a comunità di motivated learners
2020
Education of the future is a central theme in many debates nowadays. This paper focuses on the question what knowledge and skills are most relevant to prepare students for a rapidly changing society and if schools are able to respond effectively to costant transformation driven by technological innovation. While the school systemis involved in a modification process that concerns its core contents, new “wired” generations of students from lower secondary education are labelled as difficult to teach or even “unteachables”, students who are losing interest in academic learning, who are not motivated or responsible for their learning processes. The contribution examines the activities of an on…