Search results for "228"

showing 10 items of 834 documents

The Severe Asthma Network in Italy: Findings and Perspectives

2019

Background Severe Asthma Network in Italy (SANI) is a registry of patients recruited by accredited centers on severe asthma. Objective To analyze epidemiological, clinical, inflammatory, functional, and treatment characteristics of severe asthmatics from the SANI registry. Methods All consecutive patients with severe asthma were included into the registry, without exclusion criteria to have real-life data on demographics, asthma control, treatments (including biologics), inflammatory biomarkers, and comorbidities. Results A total of 437 patients (mean age: 54.1 years, 57.2% females, 70.7% atopics, 94.5% in Global Initiative for Asthma severity step V) were enrolled into the study. The mean …

AdultMalemedicine.medical_specialtyRegistrySevere asthmaExacerbationBronchiectasis; Comorbidities; Late-onset asthma; Nasal polyps; Registry; SANI; Severe asthma; Immunology and AllergyOmalizumabComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioComorbiditiesAtopy03 medical and health sciencesBronchiectasi0302 clinical medicineFood allergyInternal medicineLate-onset asthmaNasal polypsBronchiectasis; Comorbidities; Late-onset asthma; Nasal polyps; Registry; SANI; Severe asthma; Adult; Aged; Asthma; Bronchiectasis; Comorbidity; Eosinophils; Female; Humans; Immunoglobulin E; Italy; Male; Middle Aged; Nasal Polyps; Registries; RhinitisMedicineHumansBronchiectasis Comorbidities Late-onset asthma Nasal polyps Registry SANI Severe asthma Immunology and AllergyImmunology and Allergy030212 general & internal medicineRegistriesAsthmaAgedRhinitisBronchiectasisbusiness.industryNasal polypSANIImmunoglobulin EMiddle Agedmedicine.diseaseAsthmaBronchiectasisEosinophils030228 respiratory systemItalyAsthma Control QuestionnaireFemaleComorbiditiebusinessMepolizumabmedicine.drug
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Characteristics and determinants of patient burden and needs in the treatment of chronic spontaneous urticaria

2019

Objectives: Treatment of chronic spontaneous urticaria (CSU) is based on evidence-based guidelines. However, specific patient needs and benefits from therapy have not been differentiated on the guideline level. The current study was designed to use the first part of the PBI, the PNQ, to characterize[for full text, please go to the a.m. URL]

AdultMalemedicine.medical_specialtyTime FactorsCross-sectional studyHealth StatusDermatologyDiseasePatient Care Planning030207 dermatology & venereal diseases03 medical and health sciencesSex Factors0302 clinical medicineCost of IllnessQuality of lifeSurveys and QuestionnairesInternal medicinemedicineHumansChronic UrticariaDisease burdenChronic urticariaAgedbusiness.industryPruritusPatient PreferenceGuidelineMiddle Aged610 Medical sciences; MedicineCross-Sectional StudiesPatient burden030228 respiratory systemddc: 610Quality of LifeItchingFemalemedicine.symptombusinessDecision Making SharedNeeds Assessment
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Oral appliance therapy in obstructive sleep apnea: Long-term adherence and patients experiences.

2018

Background Despite the advances in the treatment of obstructive sleep apnea (OSA) with mandibular advancement appliances (MAA), their effectiveness is dependent on the patients’ compliance. Our aims were to evaluate the long-term adherence to MAA therapy and patients’ experiences of the treatment in OSA. Material and Methods Sixty-nine patients (52 males, 17 females; Mean age: 54.4±10.8 years) were included in the study. The subjects were mild (56%) and moderate (44%) OSA patients who had been treated using MAA at least 4 years prior to the study. A phone survey was used to determine the demographic characteristics of the patients, as well as to assess self-reported adherence to therapy, su…

AdultMalemedicine.medical_specialtyTime FactorsOral applianceDisease03 medical and health sciences0302 clinical medicinePatient satisfactionInternal medicinemedicineHumansGeneral DentistryIncome.statusAgedSleep Apnea Obstructivebusiness.industryResearchSleep apneaMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Medically compromised patients in DentistryTemporomandibular jointObstructive sleep apneamedicine.anatomical_structure030228 respiratory systemOtorhinolaryngologyPatient SatisfactionUNESCO::CIENCIAS MÉDICASMarital statusPatient ComplianceSurgeryFemalebusinessMandibular Advancement030217 neurology & neurosurgeryMedicina oral, patologia oral y cirugia bucal
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The Angioedema Quality of Life Questionnaire (AE-QoL) - assessment of sensitivity to change and minimal clinically important difference

2016

Background The Angioedema Quality of Life Questionnaire (AE-QoL) has recently been developed and validated as the first specific patient-reported outcome tool to assess quality of life (QoL) impairment in recurrent angioedema patients. As of yet, its sensitivity to change and minimal clinically important difference (MCID) have not been established. Methods Recurrent angioedema patients with chronic spontaneous urticaria or hereditary angioedema were repeatedly asked to complete the AE-QoL along with the SF-12 and other anchors for QoL impairment and disease activity during routine care visits. The sensitivity to change of AE-QoL was determined by correlating changes in its scores over time …

AdultMalemedicine.medical_specialtyUrticariaClinical immunologyImmunologyMinimal Clinically Important DifferenceDisease activity030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineQuality of lifeRecurrenceSurveys and QuestionnairesHumansImmunology and AllergyMedicineAngioedemaSensitivity to changeskin and connective tissue diseasesRoutine careAngioedemabusiness.industryMinimal clinically important differenceReproducibility of ResultsMiddle Agedmedicine.diseasehumanities030228 respiratory systemChronic DiseaseHereditary angioedemaQuality of LifePhysical therapyFemalesense organsmedicine.symptombusinessAllergy
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The Role of Interleukin 10 and 18 in Chronic Spontaneous Urticaria Pathogenesis in the Context of Angioedema Coexistence

2021

Chronic spontaneous urticaria (CSU) is defined using clinical symptoms as spontaneous occurrence of itchy wheals and/or angioedema for at least 6 weeks. Angioedema is underdiagnosed in CSU patients, and its presence has significant negative impact on health-related quality of life, daily activities, health care resource utilization, and work. Various cytokines have been found to be involved in pathogenesis of CSU. To study levels of interleukin (IL)-10 and IL-18 in CSU patients and to look for the differences in CSU subgroups divided with regard to angioedema reoccurrence, we included consecutive CSU patients into the study. To assess disease activity, urticaria activity score was used. In …

AdultMalemedicine.medical_specialtyUrticariaImmunologyContext (language use)DiseasePathogenesisYoung Adult030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineQuality of lifeVirologyInternal medicinemedicineHumansIn patientAngioedemaAgedAngioedemabusiness.industryInterleukin-18InterleukinCell BiologyMiddle AgedInterleukin-10Interleukin 10030228 respiratory systemChronic DiseaseFemaleDisease Susceptibilitymedicine.symptombusinessBiomarkersJournal of Interferon and Cytokine Research
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Comparison and interpretability of the available urticaria activity scores

2017

The urticaria activity score (UAS) is the gold standard for assessing disease activity in patients with chronic spontaneous urticaria (CSU). Two different versions, the UAS7 and UAS7TD , are currently used in clinical trials and routine care. To compare both versions and to obtain data on their interpretability, 130 CSU patients applied both versions and globally rated their disease activity as none, mild, moderate, or severe. UAS7 and UAS7TD values correlated strongly (r = .90, P < .001). Interquartile ranges for UAS7 and UAS7TD values for mild, moderate, and severe CSU were 11-20 and 10-24, 16-30 and 16-32, and 27-37 and 28-40. UAS7 values were slightly, but significantly lower as compare…

AdultMalemedicine.medical_specialtyUrticariaImmunologySeverity of Illness IndexMean differenceDisease activity030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineInterquartile rangeInternal medicineOutcome Assessment Health CaremedicineHumansImmunology and AllergyIn patientRoutine careInterpretabilitybusiness.industryReproducibility of ResultsGold standard (test)Middle AgedSurgeryClinical trial030228 respiratory systemFemalebusinessBiomarkersAllergy
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Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial.

2016

AdultMalemedicine.medical_specialtyUrticariaImmunologyTreatment outcomePlacebo-controlled studyMEDLINEDrug ResistanceHistamine AntagonistsOmalizumabOmalizumablaw.invention030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineRandomized controlled trialDouble-Blind MethodlawInternal medicineAnti-Allergic AgentsImmunology and AllergyMedicineHumansbusiness.industryMiddle AgedSymptomatic dermographismTreatment Outcome030228 respiratory systemMulticenter studyFemalebusinessmedicine.drugThe Journal of allergy and clinical immunology
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Omalizumab is effective in cold urticaria—results of a randomized placebo-controlled trial

2016

AdultMalemedicine.medical_specialtyUrticariaImmunologyTreatment outcomePlacebo-controlled studyMEDLINEOmalizumabOmalizumabCold urticarialaw.invention030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineDouble-Blind MethodRandomized controlled triallawInternal medicineAnti-Allergic AgentsmedicineHumansImmunology and Allergybusiness.industryMiddle Agedmedicine.diseaseCold TemperatureTreatment Outcome030228 respiratory systemMulticenter studyPhysical therapyFemalebusinessmedicine.drugJournal of Allergy and Clinical Immunology
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The Urticaria Activity Score-Validity, Reliability, and Responsiveness.

2018

Background Chronic spontaneous urticaria is characterized by fluctuating symptoms. Its activity is assessed with the urticaria activity score (UAS). Two versions of the urticaria activity score used for 7 consecutive days (UAS7) are available: (1) The guideline-recommended UAS7, with once-daily documentation, and (2) the UAS7TD, with twice-daily documentation. Objective To better characterize both UAS7 versions with regard to their validity, reliability, sensitivity to change, minimal important difference (MID), and smallest detectable change (SDC). Methods One hundred thirty adult patients with chronic spontaneous urticaria completed both UAS7 versions, the Patients Global Assessment (PatG…

AdultMalemedicine.medical_specialtyUrticariaIntraclass correlationOmalizumabOmalizumabSeverity of Illness IndexDisease activity030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineQuality of lifeimmune system diseasesInternal medicineAnti-Allergic AgentsImmunology and AllergyMedicineHumansskin and connective tissue diseasesReceiver operating characteristicbusiness.industryReproducibility of ResultsDermatology Life Quality IndexMiddle AgedStandard error030228 respiratory systemChronic DiseasePhysical therapyPatient-reported outcomeFemalebusinessmedicine.drugThe journal of allergy and clinical immunology. In practice
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Benefits of skeletal-muscle exercise training in pulmonary arterial hypertension: The WHOLEi + 12 trial

2017

Pulmonary arterial hypertension is often associated with skeletal-muscle weakness. The purpose of this randomized controlled trial was to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure-load exercises on upper/lower-body muscle power and other functional variables in patients with this disease. Participants were allocated to a control (standard care) or intervention (exercise) group (n = 20 each, 45 ± 12 and 46 ± 11 years, 60% women and 10% patients with chronic thromboembolic pulmonary hypertension per group). The intervention included five, three and six supervised (inhospital) sessions/week of aerobic, resistance and inspirato…

AdultMalemedicine.medical_specialtyWeaknessAdolescentHypertension Pulmonary030204 cardiovascular system & hematologyBreathing ExercisesBench presslaw.inventionYoung Adult03 medical and health sciences0302 clinical medicineRandomized controlled triallawInternal medicineClinical endpointHumansMedicineLeg pressExerciseAgedRetrospective StudiesExercise Tolerancebusiness.industryVO2 maxSkeletal muscleResistance TrainingMiddle AgedAparato respiratorioRespiratory Musclesmedicine.anatomical_structure030228 respiratory systemQuality of LifePhysical therapyCardiologyFemaleAnalysis of variancemedicine.symptomCardiology and Cardiovascular MedicinebusinessHipertensión pulmonarPulmones - Enfermedades
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