Search results for "243"

INfluenza Vaccine Indication during therapy with Immune checkpoint inhibitors: A multicenter prospective observational study (INVIDIa-2)

2021

BackgroundUntil now, no robust data supported the efficacy, safety and recommendation for influenza vaccination in patients with cancer receiving immune checkpoint inhibitors (ICIs).MethodsThe prospective multicenter observational INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors (INVIDIa-2) study investigated the clinical effectiveness of influenza vaccination in patients with advanced cancer receiving ICIs, enrolled in 82 Italian centers from October 2019 to January 2020. The primary endpoint was the time-adjusted incidence of influenza-like illness (ILI) until April 30, 2020. Secondary endpoints regarded ILI severity and vaccine safety.ResultsThe study enrolle…

Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative…

2016

Abstract Background Degenerative forms of mitral valve diseases (MVDs) are very complex pathologies. Thus, it is difficult to make generalizations about the disease pathways or genetic risk factors contributing to these diseases. However, a key role of metalloproteinases (MMPs) in their pathophysiology is emerging. Thus, we performed for the first time a perspective study to assess eventual associations of some functional single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes with the MVD risk, symptom severity, and short- and long-term (4.8 years) complications. Materials and methods For this purpose, 90 patients and two control groups were genotyped for rs3918242, rs243865, and r…

Food quality and nutraceutical value of nine cultivars of mango (Mangifera indica L.) fruits grown in Mediterranean subtropical environment

2019

Mango (Mangifera indica L.) quality is strongly influenced by genotype but individuating the most appropriate harvesting time is essential to obtain high quality fruits. In this trial we studied the influences of the ripening stage at harvest (mature-ripe or green-ripe) on quality of ready to eat mango fruits from nine cultivars (Carrie, Keitt, Glenn, Manzanillo, Maya, Rosa, Osteen, Tommy Atkins and Kensington Pride) grown in the Mediterranean subtropical climate through physicochemical, nutraceutical, and sensory analysis. Our results show a large variability among the different observed genotypes and in dependence of the ripening stage at harvest. With the exception of Rosa, mature-ripe f…

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

2023

The introduction of anti-SARS-CoV-2 vaccines in late 2020 substantially changed the pandemic picture, inducing effective protection in the population. However, individual variability was observed with different levels of cellular response and neutralizing antibodies. We report data on the impact of age, gender, and 16 single nucleotide polymorphisms (SNPs) of cytokine genes on the anti-SARS-CoV-2 IgG titers measured 31 and 105 days after administration of the second dose of BNT162b2 vaccine to 122 healthy subjects from the health care staff of the Palermo University Hospital, Italy. The higher titers at 31 days were measured in the younger subjects and in subjects bearing T-positive genotyp…

Recalibrating EU Foreign Policy vis-à-vis Central Asia: Towards Principled Pragmatism and Resilience

2022

With China and Russia acting more assertively vis-à-vis Central Asia, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan have gradually moved to the core of contemporary Eurasian geopolitics – albeit to varying degrees. The European Union (EU) has purposefully sought to promote its norms and values in the region for quite some time in the past. However, considering the ongoing Western “polycrisis” exacerbated by the Covid-19 pandemic most recently, our paper investigates how the EU has been recalibrating its relationship towards Central Asia – within the timespan of its two EU Central Asia Strategies, dating from 2007 and 2019, respectively. We argue that the reformulation of …

Fra Westfalen til Brussel : Portugal og Norges forhold til EU

2006

Masteroppgave i offentlig politikk og ledelse 2006 - Høgskolen i Agder, Kristiansand

¿Podremos vencer a la muerte?

2019

La rilevabilità d’ufficio delle nullità nel sistema delle eccezioni secondo le Sezioni Unite (note in margine a Cass. sez, un. 26242 e 26243 del 12 d…

2015

Quello del rilievo officioso delle nullità è uno dei temi più contrastati e discussi dibattito dottrinario e giurisprudenziale degli ultimi anni. A distanza di due anni dalla precedente sentenza 14828/2012, le Sezioni Unite tornano nuovamente sulla questione con le due decisioni "gemelle" n. 26242 e n. 26243 del 12 dicembre 2014. Intento del Giudice di legittimità è dettare una sorta di prontuario destinato ai giudici di merito, sul come comportarsi in presenza di una possibile nullità negoziale, non rilevata dalle parti. I punti essenziali del percorso logico-argomentativo (applicati, poi, a tutte le fattispecie possibili: dalle nullità di protezione, al rilievo della nullità in qualunque …

Optical counterpart to Swift J0243.6+6124

2020

Context. Swift J0243.6+6124 is a unique system. It is the first and only ultra-luminous X-ray source in our Galaxy. It is the first and only high-mass Be X-ray pulsar showing radio jet emission. It was discovered during a giant X-ray outburst in October 2017. While there are numerous studies in the X-ray band, very little is known about the optical counterpart. Aims. Our aim is to characterize the variability timescales in the optical and infrared bands in order to understand the nature of this intriguing system. Methods. We performed optical spectroscopic observations to determine the spectral type. Long-term photometric light curves together with the equivalent width of the Hα line were u…

Oiling the Wheels of Conflict? Local Grievances, Relative Deprivation and the Potential for Conflict in Cape Three Points, Ghana.

2015

Master thesis development management- University of Agder, 2015 Natural resource, particularly oil, has been predicted to be a core factor of internal conflicts in the post-cold war era (Le Billon, 2001; Klare, 2001). This thesis explores the potential for conflict in new and emerging petro-states where recent oil discoveries have raised concerns about the risk of oil conflict occurring. The relative deprivation theory (Gurr, 1970) serves as the main theoretical point of discussion for this study. Using a case study of Cape Three Points in Ghana, the study empirically examines how community level grievances, in terms of challenges and expectations connected with the discovery and production…