Search results for "24"
showing 10 items of 3907 documents
"Table 5" of "Linear and non-linear flow modes in Pb-Pb collisions at $\sqrt{s_{\rm NN}} =$ 2.76 TeV"
2019
Centrality dependence of v4 (left), v5 (middle) and v6 (right) in Pb–Pb collisions at 2.76 TeV. Contributions from linear and non-linear modes are presented with open and solid markers, respectively.
Layer-Specific Refinement of Sensory Coding in Developing Mouse Barrel Cortex
2017
Rodent rhythmic whisking behavior matures during a critical period around 2 weeks after birth. The functional adaptations of neocortical circuitry during this developmental period remain poorly understood. Here, we characterized stimulus-evoked neuronal activity across all layers of mouse barrel cortex before, during, and after the onset of whisking behavior. Employing multi-electrode recordings and 2-photon calcium imaging in anesthetized mice, we tested responses to rostro-caudal whisker deflections, axial "tapping" stimuli, and their combination from postnatal day 10 (P10) to P28. Within this period, whisker-evoked activity of neurons displayed a general decrease in layer 2/3 (L2/3) and …
Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: New perspectives for antibiodeter…
2017
Background Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. Results In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa. A time- and dose-…
PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discov…
2018
Compound libraries are important requirement in target-based drug discovery. In the present work, a small focused compound library based on β-aminoketone scaffold has been prepared combining microwave-assisted organic synthesis (MAOS) with polymer-assisted solution phase synthesis (PASPS) and replacing reaction workup standard purification procedures with solid phase extraction (SPE). Specifically, the effects of solvent, such as dioxane, dimethylformamide (DMF), polyethylene glycol 400 (PEG 400), temperature, irradiation time, stoichiometric ratio of reagents, and catalysts (HCl, acetic acid, cerium ammonium nitrate (CAN)) were investigated to maximize both conversion and yield. The optimi…
Estudio del efecto de la adenoamigdalectomía sobre el sistema inmunitario en niños
2017
La cirugía realizada sobre el anillo linfático de Waldeyer (amigdalectomía, adenoidectomía o adenoamigdalectomía) continúa siendo la más frecuentemente realizada en otorrinolaringología y es el procedimiento quirúrgico más frecuente en niños. Entendemos que el tejido linfático adenoamigdalar tiene una gran importancia en el desarrollo de la inmunidad infantil, contribuyendo al reconocimiento de gérmenes y estimulando el aumento de inmunoglobulinas específicas en suero como respuesta a la infección. Sin embargo, muchos niños tienen que ser sometidos a cirugía de extirpación adenoamigdalar por problemas médicos (principalmente amigdalitis de repetición y apnea del sueño). En vista de la impor…
ETIOBE: Un protocolo de intervención para la obesidad infantil apoyado en las tecnologías de la información y la comunicación
2015
El sobrepeso y la obesidad infantil, constituyen hoy en día un grave problema de salud en todo el mundo. La elevada prevalencia de la obesidad infantil ha llevado a que países como Estados Unidos y Europa inviertan en recursos físicos y económicos para desarrollar estrategias capaces de paliar y frenar este alarmante incremento. Sin embargo, a pesar de todo este esfuerzo, la realidad muestra cómo cada vez son más las personas afectadas de este problema. Este problema adquiere una gran magnitud debido a las consecuencias físicas, psicológicas y sociales asociadas al mismo. Ante esta problemática surge la necesidad de desarrollar programas de intervención eficaces, capaces de lograr no sólo e…
A 3D‑scaffold of PLLA induces the morphological differentiation and migration of primary astrocytes and promotes the production of extracellular vesi…
2019
The present study analyzed the ability of primary rat astrocytes to colonize a porous scaffold, mimicking the reticular structure of the brain parenchyma extracellular matrix, as well as their ability to grow, survive and differentiate on the scaffold. Scaffolds were prepared using poly-L-lactic acid (PLLA) via thermally-induced phase separation. Firstly, the present study studied the effects of scaffold morphology on the growth of astrocytes, evaluating their capability to colonize. Specifically, two different morphologies were tested, which were obtained by changing the polymer concentration in the starting solution. The structures were characterized by scanning electron microscopy, and a…
3D cultures of primary astrocytes on Poly-L-lactic acid scaffolds
Tissue engineering is an emerging multidisciplinary field that aims at reproducing in vitro tissues with morphological and functional features similar to the biological tissue of the human body. Polymeric materials can be used in contact with biological systems in replacing destroyed tissue by transplantation [1]. Several biopolymers, including poly L (lactic acid) (PLLA), have been used in biomedical applications to set scaffolds with ductile proprieties and biodegradation kinetics [2]. In particular, the PLLA scaffold topography mimics the natural extracellular matrix and makes it a good candidate for neural tissue engineering. We report about of 3D system the PLLA porous scaffolds prepar…
Green Composites Based on PLA and Agricultural or Marine Waste Prepared by FDM
2021
Three dimensional-printability of green composites is recently growing in importance and interest, especially in the view of feasibility to valorize agricultural and marine waste to attain green fillers capable of reducing bioplastic costs, without compromising their processability and performance from an environmental and mechanical standpoint. In this work, two lignocellulosic fillers, obtained from Opuntia ficus indica and Posidonia oceanica, were added to PLA and processed by FDM. Among the 3D printed biocomposites investigated, slight differences could be found in terms of PLA molecular weight and filler aspect ratio. It was shown that it is possible to replace up to 20% of bioplastic …
PLLA scaffolds with controlled architecture as potential microenvironment for in vitro tumor model
2019
Abstract The "microenvironment" where a tumor develops plays a fundamental role in determining its progression, the onset of metastasis and, eventually, its resistance to therapies. Tumor cells can be considered more or less invasive depending both on the nature of the cells and on the site where they are located. Commonly adopted laboratory culture protocols for the investigation of tumor cells take usually place on standard two-dimensional supports. However, such cultures do not allow for reproduction of the biophysical properties of the tumor’s microenvironment, thus causing the cells to lose most of their relevant characteristics. In this work MDA-MB 231 breast cancer cells were cultiva…