Search results for "25"

Estudio piloto de la influencia de una intervención basada en mindfulness y autocompasión sobre la creatividad verbal y figurativa en estudiantes uni…

2017

Resumen La formacion en habilidades creativas debe ser uno de los objetivos fundamentales en la ensenanza universitaria, ya que favorece la adaptacion y el afrontamiento eficaz de los alumnos ante las exigencias sociales y de los ambitos academico y laboral. Este estudio analiza los efectos de una intervencion basada en mindfulness y autocompasion sobre la creatividad verbal y figurativa en un grupo de estudiantes de nuevo ingreso en la universidad. La muestra del estudio estuvo formada por 23 alumnos pertenecientes al Grado de Magisterio. El grupo experimental (n = 14) formo parte de una intervencion basada en mindfulness y autocompasion de 4 semanas de duracion. En el grupo control (n = 9…

La oncología pediátrica: pasado, presente y futuro

2016

2016 - Guías europeas para el manejo de la hipertensión arterial en niños y adolescentes: nuevos conceptos para un viejo problema

2016

Varhaiskasvatuspalvelut koronapandemian aikana

2021

Raportissa esitellään varhaiskasvatuksen lähiesihenkilöille syksyllä 2020 toteutetun kyselyn tuloksia varhaiskasvatuspalveluiden tuottamisesta koronaviruspandemian aikana. Normaalioloissa kansallinen lainsäädäntö määrittelee varhaiskasvatustoiminnan reunaehdot. Keväällä 2020 koronaviruspandemian vuoksi voimaan astuneen poikkeustilan aikana kunnat kuitenkin vapautettiin varhaiskasvatuslain mukaisesta varhaiskasvatuksen järjestämisvastuusta, mikäli lapsen vanhempien tai huoltajien oli mahdollista järjestää lapsen hoito muulla tavalla. Tässä tilanteessa kunnissa ja varhaiskasvatusyksiköissä tehtiin erilaisia ratkaisuja varhaiskasvatuksen toteuttamisesta ja tarjoamisesta kotihoitoon siirtyneill…

The protein and microRNA cargo of extracellular vesicles from parasitic helminths – current status and research priorities

2020

Helminth parasites have a remarkable ability to persist within their mammalian hosts, which is largely due to their secretion of molecules with immunomodulatory properties. Although the soluble components of helminth secretions have been extensively studied, the discovery that helminths release extracellular vesicles (EVs) has added further complexity to the host-parasite interaction. Whilst several studies have begun to characterise the molecules carried by helminth EVs, work aimed at investigating their biological functions has been hindered by a lack of helminth-specific EV markers. To begin to address this, we summarised helminth EV literature to date. With a focus on the protein and mi…

Assessment of tumor-infiltrating TCRV γ 9V δ 2 γδ lymphocyte abundance by deconvolution of human cancers microarrays

2017

Most human blood γδ cells are cytolytic TCRVγ9Vδ2+lymphocytes with antitumor activity. They are currently investigated in several clinical trials of cancer immunotherapy but so far, their tumor infiltration has not been systematically explored across human cancers. Novel algorithms allowing the deconvolution of bulk tumor transcriptomes to find the relative proportions of infiltrating leucocytes, such as CIBERSORT, should be appropriate for this aim but in practice they fail to accurately recognize γδ T lymphocytes. Here, by implementing machine learning from microarray data, we first improved the computational identification of blood-derived TCRVγ9Vδ2+γδ lymphocytes and then appl…

Tumor-priming converts NK cells to memory-like NK cells

2017

Fascinating earlier evidence suggests an intrinsic capacity of human natural killer (NK) cells to acquire adaptive immune features in the context of cytomegalovirus (CMV) infection or pro-inflammatory cytokine stimulation. Since the role of memory NK cells in cancer has so far remained elusive and adoptive NK cell transfer in relapsing pediatric acute B cell precursor leukemia (BCP-ALL) patients awaits improvement, we asked the question whether tumor-priming could promote the generation of memory NK cells with enhanced graft-vs.-leukemia (GvL) reactivity. Here, we provide substantial evidence that priming of naive human NK cells with pediatric acute B cell leukemia or acute myeloid leukemia…

Evaluation of serum CA 125 levels in patients with pelvic pain related to endometriosis.

2007

The aim of the study was to investigate the clinical value of the serum CA 125 level for diagnosing and determining the severity of endometriosis and pelvic pain associated with endometriosis. Eighty-six women who underwent operative laparoscopy were enrolled. Sixty-nine women with endometriosis and 17 without endometriosis participated in this study. In all of the patients, endometriosis was diagnosed and classified into stages according to the Revised American Fertility Society (R-AFS) classification. The mean serum CA 125 levels were determined in each patient. We also investigated the relationship between serum CA 125 concentration and the intensity of dysmenorrhea and dyspareunia in t…

Cholesterol Content in Human Milk during Lactation: A Comparative Study of Enzymatic and Chromatographic Methods.

2018

This study validates a gas chromatography (GC) method for determining the sterol profile of human milk (HM) and compares it with an enzymatic-spectrophotometric (E-S) method. Good linearity ( r > 0.97) and low limits of detection and quantification were obtained with the GC method (<1.8 and <6 μg/100 g of HM, respectively). Suitable intra- and interassay precisions (all <18%) and satisfactory recovery percentages (80-109%) were obtained for both methods. In addition, both methodologies were used to assess cholesterol evolution in HM during lactation, showing a 50% decrease at 6 months versus colostrum. The E-S method overestimated cholesterol content by <20% versus the GC method. The result…

Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate c…

2017

Abstract Background Circulating cell-free miRNAs have emerged as promising minimally-invasive biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the bloodstream incorporated into extracellular vesicles (EVs) and ribonucleoprotein complexes. However, it is still debated if EVs contain biologically meaningful amounts of miRNAs and may provide a better source of miRNA biomarkers than whole plasma. The aim of this study was to systematically compare the diagnostic potential of prostate cancer-associated miRNAs in whole plasma and in plasma EVs. Methods RNA was isolated from whole plasma and plasma EV samples from a well characterised cohort of 50 patient with …