Search results for "25"

Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases.

2022

Vitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, meta-analyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is considered the Vitamin D status biomarker, in patients affected by neurological, psychiatric and autoimmune diseases. Although an association between low 25(OH)D serum levels and the prevalence of these diseases has been found, it is still unclear whether the serum 25(OH)D measurement can be clinically useful as a biomarker for diagnosis, prognosis and predicting treatment response in neurodegene…

CFD simulation of a mixing-sensitive reaction in unbaffled vessels

2008

Stirred tanks are widely used in the process industry, often to carry out complex chemical reactions. In many of such cases the perfect mixing hypothesis is not applicable for modelling purposes, and more detailed modelling approaches are required in order to accurately describe the reactor behaviour. In this work a fully predictive modelling approach, based on Computational Fluid Dynamics, is developed. Model predictions are compared with original experimental data obtained in un unbaffled stirred vessel with a parallel-competitive, mixing sensitive reaction scheme. Notably, satisfactory results are obtained at all injection rates with no recourse to micro-mixing model, thus confirming the…

The matrix metalloproteinase and insulin-like growth factor system in oral cancer – a prospective clinical study

2017

Eik Schiegnitz,1 Peer W Kämmerer,2 Holger Schön,1 Christoph Gülle,1 Manfred Berres,3,4 Keyvan Sagheb,1 Bilal Al-Nawas5 1Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, 2Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre Rostock, Rostock, 3Department of Mathematics and Technology, University of Applied Sciences Koblenz, Remagen, 4Institute of Medical Biometry, Epidemiology and Informatics, Johannes Gutenberg University of Mainz, Mainz, 5Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Martin-Luther University Ha…

ALS-RELATED FUS PROTEIN IS MISLOCALIZED TO CYTOPLASM AND RECRUITED INTO STRESS GRANULES IN FIBROBLASTS OF ASYMPTOMATIC FUS P525L MUTATION CARRIERS

Symptoms onset in Amyotrophic Lateral Sclerosis (ALS) occur when over 70% of motor neurons is already lost, suggesting a relatively long pre-symptomatic phase. The description of several genes linked to ALS (e.g., SOD1, FUS, TARDP, C9orf72) has now allowed identification of pre-symptomatic carriers. These pre-symptomatic (or even preclinical) carriers can be followed up with the aim to identify the very early clinical disease-related changes or a valuable biomarker. These efforts seem at present the best approach for the implementation of an early symptomatic therapy or for the disease prevention. In this work, we studied the expression of FUS protein in cultured skin fibroblasts from pre-s…

Regular solutions for nonlinear elliptic equations, with convective terms, in Orlicz spaces

2022

We establish some existence and regularity results to the Dirichlet problem, for a class of quasilinear elliptic equations involving a partial differential operator, depending on the gradient of the solution. Our results are formulated in the Orlicz-Sobolev spaces and under general growth conditions on the convection term. The sub- and supersolutions method is a key tool in the proof of the existence results.

Supercritical Antisolvent Extraction of Bioactive Compounds from Mango by-Products

2013

Znaczenie i rola witaminy D w praktyce farmaceutycznej

2022

Pierwsze doniesienia o witaminie D pojawiły się w pierwszej połowie XX w. Jej odkrycie wywarło istotny wpływ na prewencję i leczenie krzywicy, a także umożliwiło poznanie i udokumentowanie roli w regulacji równowagi gospodarki wapniowo-fosforanowej. Dalsze doniesienia sugerują również inne istotne dla zdrowia właściwości witaminy D, w tym wpływ na układ mięśniowy, nerwowy, immunologiczny, krążenia, gospodarkę węglowodanową, otyłość, ryzyko wystąpienia chorób nowotworowych, a także (istotne dziś) zagadnienie wpływu na przebieg i zapadalność na COVID-19. Wyróżniono sześć form witaminy D różniących się strukturą łańcuchów bocznych. Do grupy witaminy D zaliczamy: cholekalcyferol (witamina D3) p…

Comparison results for a linear elliptic equation with mixed boundary conditions

2003

In this paper we study a linear elliptic equation having mixed boundary conditions, defined in a connected open set $\Omega $ of $\mathbb{R}^{n}$. We prove a comparison result with a suitable ``symmetrized'' Dirichlet problem which cannot be uniformly elliptic depending on the regularity of $ \partial \Omega $. Regularity results for non-uniformly elliptic equations are also given.

BIOLOGICAL AND EPIDEMIOLOGICAL EXAMINATION OF TRANSDIAGNOSTIC AND SPECIFIC SYMPTOM DIMENSIONS AT PSYCHOSIS ONSET: FINDINGS FROM THE EUGEI STUDY

2018

Background Current diagnostic models of psychosis have been questioned since Kraepelin’s original dichotomy of dementia praecox and manic depression. Indeed, increasing evidence has suggested that a dimensional approach might be a valid alternative platform for research. However, while an increasing number of studies have investigated how environmental risk factors for affective and non-affective psychosis map onto symptom dimensions, only a few have examined these dimensions in relation to genetic variants as summarised by Polygenic Risk Score (PRS). Furthermore, no studies have examined the putative effect of PRS for Schizophrenia (SZ), Bipolar Disorder (BP), and Major Depressive Disorder…

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

2020

ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…