Search results for "3-d"

showing 10 items of 1132 documents

Synthesis of a Novel Hydrazone of Thieno[2,3-d]pyrimidine Clubbed with Ninhydrin: X-ray Crystal Structure and Computational Investigations

2023

The novel hydrazone-containing thieno[2,3-d]pyrimidine, namely, N′-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)-2-(4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazide 4 was synthesized in a very good yield from the reaction of the triketoester 1 or ninhydrin 2 with the exocyclic acetohydrazide 3 in methanol. Good-quality crystals of 4 were obtained by recrystallization of the compound from the DMF/MeOH solvent mixture. The target product 4 crystallized in the triclinic crystal system and P-1 space group. The topology analysis of molecular packing indicated that the H…H (30.4%), O…H (22.0%) and H…C (17.0%) contacts are the most dominant i…

kemiallinen synteesiGeneral Chemical EngineeringX-ray crystal structureCondensed Matter Physicsthieno[23-d]pyrimidinethieno[23-<i>d</i>]pyrimidineHirshfeldInorganic Chemistryhydrazonex-ray crystal structureGeneral Materials Scienceninhydrinheterosykliset yhdisteetCrystals
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P574Activation of the regulatory T-cell-indoleamine 2,3 dioxygenase Axis promotes vascular tolerance mechanisms and reduces atherosclerosis

2018

medicine.anatomical_structurePhysiologyRegulatory T cellChemistryPhysiology (medical)medicineCardiology and Cardiovascular MedicineIndoleamine 23-dioxygenaseCell biologyCardiovascular Research
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A randomized clinical trial of topical dexamethasone vs. cyclosporine treatment for oral lichen planus

2021

BACKGROUND Oral lichen planus (OLP) is a common, frequently symptomatic, immune-mediated disease. Various treatments have been used for symptomatic OLP, including corticosteroids and immunosuppressants administered topically or systemically. The aim of this study was to compare the effectiveness of topical dexamethasone vs. topical cyclosporine in treatment of symptomatic OLP. MATERIAL AND METHODS Thirty-two patients with biopsy-proven symptomatic OLP were randomly assigned to two therapeutic groups: dexamethasone 2mg/5ml or cyclosporine 100mg/ml, both administered topically in a swish and spit method three times a day for 4 weeks. The patients were followed up for a total of 6 months. Asse…

medicine.medical_specialtyTopical dexamethasoneAdministration TopicalGastroenterologyDexamethasonelaw.inventionRandomized controlled triallawInternal medicinemedicine3-d printingHumansGeneral DentistryDexamethasoneUNESCO:CIENCIAS MÉDICASbusiness.industryorthognathic surgerysplintsmedicine.diseaseDysphagiaTreatment periodDiscontinuationClinical trialOtorhinolaryngologydata accuracyCyclosporineSurgeryOral lichen planusmedicine.symptombusinessImmunosuppressive Agentsmedicine.drugLichen Planus Oral
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Reactivity of asymmetric benzo-condensed diazines with nitrilimine dipoles in the 1,3-dipolar cycloaddition reactions

2009

The reactivity of asymmetric benzo-condensed diazines in the 1,3-dipolar cycloaddition reactions with nitrilimines was investigated. The results demonstrated that, at variance with the symmetric quinoxaline, a certain grade of diastereoselectivity emerged. Moreover in the case of the 5-methylquinoxaline and quinazoline a mono-cycloadduct was obtained.

nitrilimine dipoleChemistryNitrilimine13-dipolar cycloaddition reactionOrganic ChemistrydiazineSettore CHIM/06 - Chimica OrganicadiastereoselectivityPhotochemistrySettore CHIM/08 - Chimica FarmaceuticaBiochemistryCycloadditionchemistry.chemical_compoundDipoleQuinoxalineComputational chemistryDrug Discovery13-Dipolar cycloadditionQuinazolineReactivity (chemistry)Tetrahedron Letters
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Indān-1,3-diona atvasinājumu sintēze

2022

Darbā veikta 5,6-diaizvietotu-3-(diciānometilidēn)indān-1-onu sintēze to izmantošanai fotoelementos. Literatūras apskatā aplūkota informācija par fotoelementiem un iespējamu sintēzes ceļu mērķsavienojumu iegūšanai, tai skaitā superbāzu izmantošanu buta-1,3-diēna dianjona iegūšanā.

organiskie pusvadītājisuperbāzebuta-13-diēna dianjonsindāndionsĶīmija
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Synthesis of new hybrid 1,4-thiazinyl-1,2,3-dithiazolyl radicals via Smiles rearrangement

2017

The condensation reaction of 2-aminobenzenethiols and 3-aminopyrazinethiols with 2-amino-6-fluoro-N-methylpyridinium triflate afforded thioether derivatives that were found to undergo Smiles rearrangement and cyclocondensation with sulphur monochloride to yield new hybrid 1,4-thiazine-1,2,3-dithiazolylium cations. The synthesized cations were readily reduced to the corresponding stable neutral radicals with spin densities delocalized over both 1,4-thiazinyl and 1,2,3-dithiazolyl moieties. peerReviewed

synthesis010405 organic chemistryChemistryRadical12010402 general chemistryPhotochemistryCondensation reaction01 natural sciences0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundDelocalized electron14-thiazinyl-123-dithiazolyl radicalsThioether4-thiazinyl-1Smiles rearrangementYield (chemistry)Polymer chemistrysynteesiSmiles rearrangementTrifluoromethanesulfonateta1163-dithiazolyl radicalsDalton Transactions
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CCDC 1444032: Experimental Crystal Structure Determination

2016

Related Article: Fares Ibrahim Amr, Carlos Vila, Gonzalo Blay, M. Carmen Muñoz and José R. Pedro|2016|Adv.Synth.Catal.|358|1583|doi:10.1002/adsc.201600036

t-butyl (1-benzyl-5-chloro-3-(34-dimethyl-5-oxo-1-phenyl-45-dihydro-1H-pyrazol-4-yl)-2-oxo-23-dihydro-1H-indol-3-yl)carbamateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2092891: Experimental Crystal Structure Determination

2021

Related Article: Laura Carceller-Ferrer, Carlos Vila, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro|2021|Org.Lett.|23|7391|doi:10.1021/acs.orglett.1c02571

t-butyl {1-(methoxymethyl)-3-[2-(3-methyl-5-oxo-1-phenyl-15-dihydro-4H-pyrazol-4-ylidene)propyl]-2-oxo-23-dihydro-1H-indol-3-yl}carbamateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 169925: Experimental Crystal Structure Determination

2001

Related Article: B.Abouhamza, M.Ait Ali, S.Allaoud, O.Blacque, B.Frange, A.Karim|2001|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|57|796|doi:10.1107/S0108270101006187

trans-(eta^6^-7-chloro-3-(3-chloro-2-methylphenyl)-248-trimethyl-1234-tetrahydro-24-dibora-13-diazanaphthalene)-tricarbonyl-chromium(0)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1512900: Experimental Crystal Structure Determination

2017

Related Article: Shobhraj Haldar, Gonela Vijaykumar, Luca Carrella, Steven Batha, Ghezai T. Musie, Manindranath Bera|2017|ACS Omega|2|1535|doi:10.1021/acsomega.7b00189

tri-sodium (bis(mu-22'-((2-oxidopropane-13-diyl)bis((((pyridin-2-yl)methyl)azanediyl)methylene))dibenzoato)-(mu-phosphato)-tetra-copper) dihydroxide tetradecahydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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