Search results for "311"
showing 10 items of 433 documents
Facilitadores y flujos de aprendizaje como agentes dinamizadores en la gestión del capital intelectual y la performance corporativa
2012
El propósito fundamental de esta investigación es explorar hasta qué punto los componentes del capital intelectual establecen relaciones con los facilitadores para la creación de conocimiento, también con los flujos de aprendizaje feedback y feedforward, y cómo pueden estos, a su vez, influir en la performance de la organización. Para la consecución de este objetivo hemos estructurado este trabajo en tres grandes bloques. El primero de ellos incluye los fundamentos teóricos y ofrece una revisión de la investigación previa y de los conceptos relevantes de este trabajo. Está estructurado en tres capítulos: en el primero se realiza una aproximación del capital intelectual en el marco de la Teo…
Sistemas de visión frameless, procesado hardware AER y procesado de la información mediante eventos
2018
La democratización de las cámaras de visión en nuestra vida cotidiana ha tomado fuerza pues cada vez son más pequeñas, con procesamiento más potente y menor consumo de energía, facilitando su implementación en diferentes dispositivos de tamaños que hasta hace pocos años se creía imposible y que ahora encontramos en casi cualquier lugar. Existen aplicaciones de visión artificial en las que el desempeño apenas se ha visto mejorado en las últimas décadas, aquellas en las que prima la velocidad de procesamiento más allá de la resolución y calidad de la imagen. Estas aplicaciones las abarca principalmente el sector de la industria de la manufactura y procesos, con aplicaciones de lectura de códi…
Cortical networks show characteristic recruitment patterns after somatosensory stimulation by pneumatically evoked repetitive hand movements in newbo…
2022
Abstract Controlled assessment of functional cortical networks is an unmet need in the clinical research of noncooperative subjects, such as infants. We developed an automated, pneumatic stimulation method to actuate naturalistic movements of an infant’s hand, as well as an analysis pipeline for assessing the elicited electroencephalography (EEG) responses and related cortical networks. Twenty newborn infants with perinatal asphyxia were recruited, including 7 with mild-to-moderate hypoxic–ischemic encephalopathy (HIE). Statistically significant corticokinematic coherence (CKC) was observed between repetitive hand movements and EEG in all infants, peaking near the contralateral sensorimotor…
Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold
2022
Human pluripotent stem cells (hPSC) derived neurons are emerging as a powerful tool for studying neurobiology, disease pathology, and modeling. Due to the lack of platforms available for housing and growing hPSC-derived neurons, a pressing need exists to tailor a brain-mimetic 3D scaffold that recapitulates tissue composition and favourably regulates neuronal network formation. Despite the progress in engineering biomimetic scaffolds, an ideal brain-mimetic scaffold is still elusive. We bioengineered a physiologically relevant 3D scaffold by integrating brain-like extracellular matrix (ECM) components and chemical cues. Culturing hPSCs-neurons in hyaluronic acid (HA) gels and HA-chondroitin…
Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria
2015
Department of Chemistry, Nanoscience Center, University of Jyväskylä, FI-40014, Jyväskylä, Finland Cyclodextrins are cyclic oligosaccharides widely used in the pharmaceutical industry to improve drug delivery and to increase the solubility of hydrophobic compounds. Anabaenolysins are lipopeptides produced by cyanobacteria with potent lytic activity in cholesterolcontaining membranes. Here, we identified the 23- To 24-kb gene clusters responsible for the production of the lipopeptide anabaenolysin. The hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic gene cluster is encoded in the genomes of three anabaenolysin-producing strains of Anabaena.We detected previously u…
Physical activity and sedentary time in relation to academic achievement in children
2017
Objectives To investigate the independent and combined associations of objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) with reading and arithmetic skills. Design Cross-sectional/prospective. Methods Participants were 89 boys and 69 girls aged 6–8 years. MVPA and ST were measured using a combined heart rate and movement sensor and body fat percentage by dual-energy X-ray absorptiometry in Grade 1. Reading fluency, reading comprehension, and arithmetic skills were assessed using standardized tests in Grades 1–3. The data were analyzed using linear regression analyses and analyses of covariance with repeated measures. Results In boys, MVPA was directl…
Ajokyvyn arviointi MoCA-menetelmällä Alzheimerin taudin varhaisvaiheessa
2019
Vertaisarvioitu Lähtökohdat Tutkimme Montreal Cognitive Assessment (MoCA) -menetelmän soveltuvuutta varhaista Alzheimerin tautia sairastavien potilaiden ajokyvyn arviointiin. Selvitimme myös menetelmän herkkyyttä tunnistaa kognitiomuutoksia. Menetelmät Tutkimus sisälsi haastattelun, kognitiivisen arvioinnin (MoCA), ajon simulaattorilla ja oman ajamisen arvioinnin. Siihen osallistui 7 potilasta ja 17 tervettä ikätoveria. Tulokset Potilaat suoriutuivat verrokkeja heikommin MoCA-testissä ja simulaattoriajossa. Arvio omasta suoriutumisesta ajossa oli heillä merkitsevästi parempi kuin verrokeilla. Potilaat saivat testipisteitä keskimäärin 18,6 ja verrokit 27,4. Simulaattoriajossa potilaat tekivä…
It's Sad but I Like It The Neural Dissociation Between Musical Emotions and Liking in Experts and Laypersons
2016
Emotion-related areas of the brain, such as the medial frontal cortices, amygdala, and striatum, are activated during listening to sad or happy music as well as during listening to pleasurable music. Indeed, in music, like in other arts, sad and happy emotions might co-exist and be distinct from emotions of pleasure or enjoyment. Here we aimed at discerning the neural correlates of sadness or happiness in music as opposed those related to musical enjoyment. We further investigated whether musical expertise modulates the neural activity during affective listening of music. To these aims, 13 musicians and 16 non-musicians brought to the lab their most liked and disliked musical pieces with a …
Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening
2018
Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes. Here, the aim was to discover novel RORγt ligands using both standard molecular docking and negative image-based screening. Interestingly, both of these in silico techniques put forward mostly the same compounds for experimental testing. In total, 11 of the 34 molecules purchased for testing were verified as RORγt inverse agonists, thus making the effective hit rate 32%. The pIC50 values for the compounds varied from 4.9 (11 μ…
Audiovisual processing of Chinese characters elicits suppression and congruency effects in MEG
2019
Learning to associate written letters/characters with speech sounds is crucial for reading acquisition. Most previous studies have focused on audiovisual integration in alphabetic languages. Less is known about logographic languages such as Chinese characters, which map onto mostly syllable-based morphemes in the spoken language. Here we investigated how long-term exposure to native language affects the underlying neural mechanisms of audiovisual integration in a logographic language using magnetoencephalography (MEG). MEG sensor and source data from 12 adult native Chinese speakers and a control group of 13 adult Finnish speakers were analyzed for audiovisual suppression (bimodal responses…