Search results for "31"
showing 10 items of 4401 documents
Las huellas de la interdisciplinariedad en la trayectoria de Enric Mestre. ?Intercambios e investigaciones cruzadas entre las esculturas cerámicas y …
2020
La destacada actividad artística de Enric Mestre (Alboraya / Valencia, 1936) solo pude abordarse, en su compleja diversidad y riqueza, si se mantiene, como eje metodológico básico de su estudio crítico, el abierto enfoque de su sistemática interdisciplinariedad. Los diálogos e intercambios entre la escultura cerámica, la arquitectura, la pintura, el dibujo y los murales conforman precisamente el ámbito plural de su constante quehacer artístico. Especialmente la investigación se centra en las esculturas cerámicas y en las pinturas geométricas, que constituyen los dos dilatados campos de su creación plástica, cultivados asiduamente, a lo largo del último medio siglo
Strategies of Identification of a Base-Isolated Hospital Building by Coupled Quasi-Static and Snap-Back Tests
2020
In this paper, the description of a series of quasi-static pushing tests and dynamic snap-back tests is proposed, involving the base-isolated emergency building of the Palermo university hospital. The base isolation system is characterized by a set of double-curved friction pendulum isolators placed on the top of the columns of the underground level, characteristics that cannot be found in the experimental studies available in the literature. The aim of the work was to investigate the static and dynamic properties of the building in question and comparing the in-situ results with the characteristics assigned during the design process and to assess the level of agreement. Static lateral push…
Zika virus. A teratogenic agent for the eyes
2017
Teniasis en una niña española
2017
Blastocystis sp., an emerging parasite with controversial pathogenicity. Should all human cases be treated?
2018
Echovirus 1 internalization negatively regulates epidermal growth factor receptor downregulation
2016
We have demonstrated previously that the human picornavirus Echovirus 1 (EV1) triggers an infectious internalization pathway that follows closely, but seems to stay separate, from the epidermal growth factor receptor (EGFR) pathway triggered by epidermal growth factor (EGF). Here, we confirmed by using live and confocal microscopy that EGFR and EV1 vesicles are following intimately each other but are distinct entities with different degradation kinetics. We show here that despite being sorted to different pathways and located in distinct endosomes, EV1 inhibits EGFR downregulation. Simultaneous treatment with EV1 and EGF led to an accumulation of EGFR in cytoplasmic endosomes, which was evi…
Neither Diplectanum nor specific: a dramatic twist to the taxonomic framework of Diplectanum (Monogenea: Diplectanidae).
2019
The taxonomy of the genus Diplectanum has been exclusively based on morphological features, with 28 nominal species parasitic on perciform fishes recognised. We used molecular data, to our knowledge for the first time, to evaluate the taxonomic framework of Diplectanum, infer the relationships amongst species attributed to this genus, re-assess the degree of host specificity and explore the population genetic structure of Diplectanum spp. parasitising Mediterranean sciaenids, which are potential target fish species for aquaculture diversification in the region. A minimum of 10 specimens of Diplectanum spp. were sequenced per host species (Argyrosomus regius, Sciaena umbra, Umbrina canariens…
Injury-activated glial cells promote wound healing of the adult skin in mice
2018
Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously…
The protein and microRNA cargo of extracellular vesicles from parasitic helminths – current status and research priorities
2020
Helminth parasites have a remarkable ability to persist within their mammalian hosts, which is largely due to their secretion of molecules with immunomodulatory properties. Although the soluble components of helminth secretions have been extensively studied, the discovery that helminths release extracellular vesicles (EVs) has added further complexity to the host-parasite interaction. Whilst several studies have begun to characterise the molecules carried by helminth EVs, work aimed at investigating their biological functions has been hindered by a lack of helminth-specific EV markers. To begin to address this, we summarised helminth EV literature to date. With a focus on the protein and mi…
NMR Investigation of Structures of G-Protein Coupled Receptor Folding Intermediates
2016
Folding of G-protein coupled receptors (GPCRs) according to the two-stage model (Popot, J. L., and Engelman, D. M. (1990) Biochemistry 29, 4031-4037) is postulated to proceed in 2 steps: partitioning of the polypeptide into the membrane followed by diffusion until native contacts are formed. Herein we investigate conformational preferences of fragments of the yeast Ste2p receptor using NMR. Constructs comprising the first, the first two, and the first three transmembrane (TM) segments, as well as a construct comprising TM1-TM2 covalently linked to TM7 were examined. We observed that the isolated TM1 does not form a stable helix nor does it integrate well into the micelle. TM1 is significant…