6533b7dafe1ef96bd126ec52
RESEARCH PRODUCT
Injury-activated glial cells promote wound healing of the adult skin in mice
Lukas SommerSabine WernerUna RiekstinaUeli SuterSimon M. SchaeferVadims ParfejevsVadims ParfejevsJulien DebbacheMareen GlauschMichael WegnerOlga Shakhovasubject
0301 basic medicine10017 Institute of AnatomyGeneral Physics and AstronomyTransforming Growth Factor betaMedicinelcsh:ScienceMyofibroblastsCells CulturedSkinMice KnockoutMultidisciplinaryintegumentary systemSOXE Transcription FactorsQCell CycleCell Differentiation3100 General Physics and AstronomyCell biologyMice Inbred DBACutaneous woundMyofibroblastNeurogliaSignal TransductionMice 129 StrainScienceMice Transgenic610 Medicine & health1600 General ChemistryGeneral Biochemistry Genetics and Molecular BiologyArticle03 medical and health sciencesParacrine signallingDownregulation and upregulationIn vivoFate mapping1300 General Biochemistry Genetics and Molecular BiologyAnimalsHumansEpithelial proliferationWound Healingbusiness.industryGene Expression ProfilingGeneral ChemistryMice Inbred C57BL030104 developmental biology10032 Clinic for Oncology and Hematology570 Life sciences; biologylcsh:QWound healingbusinessdescription
Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously associated with wound healing and promote myofibroblast differentiation by paracrine modulation of TGF-β signalling. Accordingly, depletion of these cells impairs epithelial proliferation and wound closure through contraction, while their expansion promotes myofibroblast formation. Thus, injury-activated glia and/or their secretome might have therapeutic potential in human wound healing disorders.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-16 |