Search results for "31"

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Neg…

2015

BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 μM). Exposure of cells to BC-11, either pre-absorbed with a soluble preparation of the N-terminal fragment of urokinase-plasminogen activator (uPa), or in co-treatment with two different EGFR inhibitors, indicated that: (i) BC-11 acts via binding to the N-terminus of the enzyme where uPa- and EGF receptor-recognizing sites are present, thereby abrogating the growth-sustaining effect resulting from receptor binding

D vitamīna receptora gēna polimorfismu saistība ar bronhiālo astmu Latvijas populācijā

2021

D vitamīna receptors (VDR) nodrošina D vitamīna funkciju izpildi organismā. To kodē VDR – plejotropisks gēns, kas tiek asociēts ar autoimunitāti, dažādām iekaisuma un alerģiskām slimībām, tai skaitā arī bronhiālo astmu (BA). Bronhiālā astma ir ģenētiski sarežģīta un heterogēna hroniska elpceļu iekaisuma slimība. VDR sekvences varianti rs731236 un rs1544410 tiek pētīti kā potenciāli bronhiālas astmas risku ietekmējoši faktori. Šī pētījuma mērķis bija analizēt VDR gēna viena nukleotīda polimorfismu (SNP; single nucleotide polymorphism) rs731236 A/G un rs1544410 C/T asociāciju ar bronhiālo astmu Latvijas populācijā. Lai noskaidrotu šo SNP potenciālo ietekmi uz saslimšanas iespējamību, pēc rest…

On the harvest of rainfall energy by means of piezoelectric transducer

2013

In this paper a detailed study on the harvest of the energy contained in rainfall by means of piezoelectric transducers is presented. Diverse studies agree on the level of suitable generated voltage on the electrodes of a piezoelectric transducer subjected to rainfall, but a complete characterization on the supplied power is still missing. This work, in order to limit optimistic forecasts, takes into account the behavior of the transducers subjected to real and also artificial rainfall, condition that has shown promising behavior in laboratory. In order to increase the energy harvesting and also define its limits different loads have been taken into account. Only commercial transducers have…

Neurosis y Gastralgia según Juan Bta. Peset y Vidal (1869)

1998

The article consist of two parts. The first is a summary of the treaty in which the main ideas about diseases analysed by the doctor Peset and Vidal are presented. The second part is a comparative analysis of the text for which the author has consulted many books and other material of those days, as well as medical dictionaries. As a result of it, the author presents the "gastralgia" as a digestive neurosis.

Overview and experimental analysis of MC SPWM techniques for single-phase five level cascaded H-bridge FPGA controller-based

2016

This paper presents an overview and experimental analysis of the MC SPWM techniques for single-phase cascaded H-bridge inverter. The multilevel power converters are an alternative to traditional converters known as “three-level converters”. The voltage waveforms and the related frequency spectra, which have been obtained by simulation analysis in Matlab-Simulink environment, are here reported for all the proposed modulation techniques. The simulation results have been experimentally validated through means of a DC/AC, five-level, single-phase converter prototype with an appropriate test bench.

Towards a critical understanding of data visualisation in democracy: a deliberative systems approach

2021

Data and data visualisations – in the forms of graphs, charts and maps – are becoming an increasingly important feature of social, public and political life. Yet within existing scholarship, the democratic significance of data visualisations has thus far received minimal attention. This article offers a first systematic attempt to make sense of and scrutinise the role of data visualisation in democracy. We apply deliberative systems theory in the analysis of three original case studies to elucidate how data visualisation can integrate into the overall anatomy of democracy, and to normatively assess how data visualisation contributes towards key democratic ideals. Conclusively, we highlight …

Probing neural mechanisms of music perception, cognition, and performance using multivariate decoding.

2012

Recent neuroscience research has shown increasing use of multivariate decoding methods and machine learning. These methods, by uncovering the source and nature of informative variance in large data sets, invert the classical direction of inference that attempts to explain brain activity from mental state variables or stimulus features. However, these techniques are not yet commonly used among music researchers. In this position article, we introduce some key features of machine learning methods and review their use in the field of cognitive and behavioral neuroscience of music. We argue for the great potential of these methods in decoding multiple data types, specifically audio waveforms, e…

School PE through Internet discussion forums

2013

Background: Physical education is a subject that generates strong feelings and emotions, as can be seen in written accounts of PE experiences. It is also important to listen to students' voices in the research context. Nowadays, students can be listened to in a new way – through the Internet. Various discussion forums on the Internet make it possible for people to express themselves through real or imagined messages. It might be easier to express highly sensitive and even intimate thoughts on the Internet. Thus, the Internet might be an interesting open forum for teachers to think about new ways of developing teaching practices that would reduce negative experiences of PE.Purpose: The purpo…

Liquen plano hipertrófico: importancia del seguimiento y de la correlación clinicopatológica

2021

Critical aspects of student teachers’ conceptions of learning

2011

Abstract The aim of this phenomenographic study was to discover the educationally critical aspects of learning conceptions among health education student teachers (N = 20). The qualitative data consisted of written essays and semi-structured interviews. Six qualitatively distinctive conceptions of learning could be discerned, namely learning as 1) the reproduction of acquired health knowledge, 2) the application of health knowledge, 3) developing personal meanings on health matters, 4) the transformation of individual thinking, 5) personal growth, and 6) collective meaning-making. These qualitatively distinct categories were reflected through three themes, which embodied critical aspects: t…